ROCK
Los inhibidores de la quinasa asociada a Rho (ROCK) se dirigen a las quinasas ROCK, que están involucradas en la regulación del citoesqueleto, la forma celular y la motilidad. ROCK desempeña un papel significativo en el control de la división celular, particularmente en procesos como la citocinesis. Inhibir ROCK puede provocar cambios en la dinámica del ciclo celular, la motilidad celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer, la neurobiología y los estudios cardiovasculares. En CymitQuimica, ofrecemos una selección de inhibidores de ROCK de alta calidad para apoyar su investigación en biología celular, dinámica del citoesqueleto y mecanismos de enfermedades.
Se han encontrado 62 productos para "ROCK".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
SR-3677
CAS:SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Fórmula:C22H24N4O4Pureza:98.46%Forma y color:SolidPeso molecular:408.45Y-27632
CAS:Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.Fórmula:C14H21N3OPureza:99.53% - 99.87%Forma y color:SolidPeso molecular:247.34RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.70% - ≥95%Forma y color:White SolidPeso molecular:340.4Ref: TM-T2011
500µg50,00€1mg66,00€5mg135,00€1mL*10mM (DMSO)152,00€10mg197,00€25mg349,00€50mg512,00€100mg730,00€Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Fórmula:C14H17N3O3SPureza:98.13%Forma y color:White SolidPeso molecular:307.37GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Fórmula:C29H30N8O5Pureza:99.14% - 99.71%Forma y color:Yellow SolidPeso molecular:570.6GSK429286A
CAS:GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).Fórmula:C21H16F4N4O2Pureza:97.68% - 98.49%Forma y color:SolidPeso molecular:432.37SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFórmula:C14H17ClN2O2Pureza:99.15%Forma y color:SolidPeso molecular:280.75SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Fórmula:C14H16N2O2Pureza:99.42%Forma y color:White SolidPeso molecular:244.29Ref: TM-T7391
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg128,00€50mg200,00€100mg319,00€200mg474,00€AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Forma y color:SolidPeso molecular:313.78ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Fórmula:C18H13ClF2N6OPureza:97.29%Forma y color:SolidPeso molecular:402.79Ref: TM-TQ0110
1mg108,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg416,00€25mg670,00€50mg954,00€100mg1.288,00€Netarsudil mesylate
CAS:Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Fórmula:C30H35N3O9S2Pureza:99.7%Forma y color:SolidPeso molecular:645.74Ref: TM-T10358L2
1mg34,00€5mg66,00€1mL*10mM (DMSO)96,00€10mg105,00€25mg236,00€50mg409,00€100mg700,00€Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Fórmula:C14H13NO7Pureza:98.16% - 99.58%Forma y color:White SolidPeso molecular:307.26ZINC00881524
CAS:ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.Fórmula:C21H20N2O3SPureza:99.48%Forma y color:SolidPeso molecular:380.46Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Forma y color:White SolidPeso molecular:327.83GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Fórmula:C24H16Cl2F2N6OPureza:99.29%Forma y color:SolidPeso molecular:513.33Ref: TM-T4488
1mg44,00€2mg56,00€5mg87,00€1mL*10mM (DMSO)89,00€10mg111,00€25mg168,00€50mg258,00€100mg430,00€HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Forma y color:White SolidPeso molecular:277.34Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Forma y color:White SolidPeso molecular:452.51Ref: TM-T6867
2mg46,00€5mg70,00€1mL*10mM (DMSO)74,00€10mg95,00€25mg158,00€50mg236,00€100mg356,00€500mg848,00€Y-27632 dihydrochloride
CAS:View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.Fórmula:C14H21N3O·2HClPureza:97.96% - 99.98%Forma y color:SolidPeso molecular:320.26BDP5290
CAS:BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)Fórmula:C17H18ClN7OPureza:97.22%Forma y color:White SolidPeso molecular:371.82Ref: TM-T7301
1mg52,00€2mg77,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg178,00€25mg369,00€50mg535,00€100mg780,00€Afuresertib
CAS:Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFórmula:C18H17Cl2FN4OSPureza:97.51% - 99.51%Forma y color:SolidPeso molecular:427.32Ref: TM-T1911
1mg37,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg92,00€25mg166,00€50mg259,00€100mg452,00€500mg982,00€
