ROCK
Los inhibidores de la quinasa asociada a Rho (ROCK) se dirigen a las quinasas ROCK, que están involucradas en la regulación del citoesqueleto, la forma celular y la motilidad. ROCK desempeña un papel significativo en el control de la división celular, particularmente en procesos como la citocinesis. Inhibir ROCK puede provocar cambios en la dinámica del ciclo celular, la motilidad celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer, la neurobiología y los estudios cardiovasculares. En CymitQuimica, ofrecemos una selección de inhibidores de ROCK de alta calidad para apoyar su investigación en biología celular, dinámica del citoesqueleto y mecanismos de enfermedades.
Se han encontrado 66 productos para "ROCK".
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GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Fórmula:C24H16Cl2F2N6OPureza:99.29%Forma y color:SolidPeso molecular:513.326Netarsudil mesylate
CAS:Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Fórmula:C30H35N3O9S2Pureza:99.7%Forma y color:SolidPeso molecular:645.74CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.71%Forma y color:SolidPeso molecular:457.4779H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Fórmula:C16H21N3O2SPureza:98.01%Forma y color:SolidPeso molecular:319.42Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Fórmula:C16H16N4OPureza:98%Forma y color:SolidPeso molecular:280.32SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Fórmula:C15H20Cl2N8O2Pureza:98%Forma y color:SolidPeso molecular:415.28Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.8%Forma y color:Yellow SolidPeso molecular:352.496AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Fórmula:C20H19N3O2Pureza:99.86%Forma y color:Yellow SolidPeso molecular:333.38Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Fórmula:C12H13N3OPureza:99.87%Forma y color:SolidPeso molecular:215.2511CID-5056270
CAS:CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphomaFórmula:C17H13N3O3SPureza:99.6%Forma y color:White SolidPeso molecular:339.368Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Fórmula:C24H28N4O4Pureza:99.67% - 99.84%Forma y color:SolidPeso molecular:436.5035LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Fórmula:C23H29N7O3Pureza:99.08%Forma y color:SolidPeso molecular:451.5215ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Fórmula:C17H17N3O2SPureza:98%Forma y color:SolidPeso molecular:327.4ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Fórmula:C20H20FN5O2Pureza:98%Forma y color:SolidPeso molecular:381.4ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Forma y color:SolidPeso molecular:521.95ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Fórmula:C18H12N6OSPureza:99.65%Forma y color:SolidPeso molecular:360.392ROCK-IN-8
CAS:ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Fórmula:C30H25FN4O4SPureza:98%Forma y color:SolidPeso molecular:556.61BDP8900
CAS:BDP8900 is a highly selective MRCK inhibitor with clear discrimination from ROCK kinases, along with biochemical and cellular evidence, and is suitable for research on MRCK-related cytoskeletal signaling, cell migration, and invasion mechanisms.Fórmula:C19H23N5SPureza:99.58% - >99.99%Forma y color:SolidPeso molecular:353.48ROCK-IN-1
CAS:ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFórmula:C20H18FN3OPureza:99.80%Forma y color:Yellow SolidPeso molecular:335.3748H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Fórmula:C16H23Cl2N3O2SPureza:99.85%Forma y color:White SolidPeso molecular:392.34
