HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Se han encontrado 178 productos para "HSP".
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Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Forma y color:SolidPeso molecular:429.85CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Fórmula:C22H20ClN5O3SPureza:99.59%Forma y color:SolidPeso molecular:469.94IPI-493
CAS:IPI-493 is a bioactive chemical.Fórmula:C28H39N3O8Pureza:99.86%Forma y color:SolidPeso molecular:545.62Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Fórmula:C14H11NO4Pureza:99.03% - 99.96%Forma y color:SolidPeso molecular:257.24Ref: TM-T10860
2mg44,00€5mg66,00€1mL*10mM (DMSO)66,00€10mg102,00€25mg205,00€50mg333,00€100mg513,00€200mg737,00€500mg1.108,00€GRP78-IN-3
CAS:GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Fórmula:C17H18N4O2SPureza:99.49%Forma y color:SolidPeso molecular:342.42Ethoxyquin
CAS:Producto controladoEthoxyquin (Santoflex) is an antioxidant used in animal feeds.Fórmula:C14H19NOPureza:97.15% - 98.73%Forma y color:Yellow LiquidPeso molecular:217.31Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Fórmula:C31H35N2NaO11Pureza:99% - 99.51%Forma y color:SolidPeso molecular:634.61Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Fórmula:C38H52O10Pureza:98%Forma y color:SolidPeso molecular:668.81TBPH
TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.NPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Fórmula:C32H32FN5O4Pureza:99.29%Forma y color:SolidPeso molecular:569.63Ref: TM-T9804
1mg90,00€5mg226,00€1mL*10mM (DMSO)284,00€10mg355,00€25mg593,00€50mg845,00€100mg1.153,00€gp96-II
Gp96-II is a gp96-blocking peptide that antagonizes cytokine production induced by gp96-mediated LPS. This compound is useful for research into inflammatory diseases.Fórmula:C200H353N59O53SForma y color:SolidPeso molecular:4464.37NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFórmula:C28H32N2O3SPureza:98%Forma y color:SolidPeso molecular:476.63PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.Fórmula:C43H50N6O7Pureza:98%Forma y color:SolidPeso molecular:762.89HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Fórmula:C29H48O10Pureza:98%Forma y color:SolidPeso molecular:556.69HS-27
CAS:HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Fórmula:C52H60N6O12SPureza:98.56%Forma y color:SolidPeso molecular:993.13Ref: TM-T18018
1mg95,00€5mg203,00€10mg326,00€1mL*10mM (DMSO)358,00€25mg580,00€50mg803,00€100mg1.099,00€Hsp90-IN-36
Hsp90-IN-36 (compound 5) is an Hsp90 inhibitor with anticancer properties and exhibits an IC50 value of 14.74 μM against MCF-7 cells.Fórmula:C20H13F4N3O4Forma y color:SolidPeso molecular:435.328PAR4 antagonist 7
PAR4 antagonist7 (Compound 20f) is a selective PAR4 antagonist (IC50: 1.72 nM), effective in inhibiting platelet aggregation induced by PAR4 agonists. It exhibits good metabolic stability and has not shown any tendency to cause bleeding in mice.Fórmula:C28H20FN5O4SForma y color:SolidPeso molecular:541.55JG-258
CAS:JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Fórmula:C20H22ClN3OS3Forma y color:SolidPeso molecular:452.06HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Pureza:98%Forma y color:Odour SoliddPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Forma y color:Odour SolidMPC-0767
CAS:MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.Fórmula:C26H36BrN7O9S2Forma y color:SolidPeso molecular:734.64Neoantimycin
CAS:Neoantimycin: S. orinoci antibiotic, mild antifungal, like antimycin, from different Streptomyces, biosynthesis known, active variants found.Fórmula:C36H46N2O12Forma y color:SolidPeso molecular:698.7663-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:99.88%Forma y color:SolidPeso molecular:269.26HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Fórmula:C27H33N5O5Forma y color:SolidPeso molecular:507.58TRAP1-IN-1
CAS:TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.Fórmula:C45H39F7N2O4P2Pureza:98%Forma y color:SolidPeso molecular:866.74DN401
CAS:DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Fórmula:C13H9BrClN5O2Pureza:99.37%Forma y color:SolidPeso molecular:382.6Ref: TM-T27193
1mg175,00€1mL*10mM (DMSO)385,00€5mg388,00€10mg572,00€25mg888,00€50mg1.224,00€100mg1.648,00€500mg3.312,00€NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.84%Forma y color:Yellow SolidPeso molecular:454.43Ref: TM-T6609
2mg39,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg187,00€50mg294,00€100mg419,00€200mg590,00€Arimoclomol citrate
CAS:Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.Fórmula:C20H28ClN3O10Forma y color:SolidPeso molecular:505.91p5 Ligand for Dnak and DnaJ
CAS:P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.Fórmula:C44H81N15O11SPureza:98%Forma y color:SolidPeso molecular:1028.27NDNA4
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.Fórmula:C31H35F3N2O5SPureza:98%Forma y color:SolidPeso molecular:604.68PROTAC HSP90 degrader BP3
CAS:PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.Fórmula:C32H29ClN8O5Forma y color:SolidPeso molecular:641.08Chetomin
CAS:Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolarFórmula:C31H30N6O6S4Pureza:98%Forma y color:Off-White To Fawn SolidPeso molecular:710.87MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Fórmula:C54H66N4O10Forma y color:SolidPeso molecular:931.12Gamitrinib TPP
CAS:Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Fórmula:C52H65N3O8PPureza:98%Forma y color:SolidPeso molecular:891.0786BrCaQ-C10-TPP
6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.Fórmula:C45H47Br2N2O3PForma y color:SolidPeso molecular:854.65Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Fórmula:C41H64N12O12SPureza:98%Forma y color:SolidPeso molecular:949.0917-DMAP-GA
CAS:17-DMAP-GA, a Geldanamycin analogue, acts as an HSP90 inhibitor, leading to cell cycle abnormalities.Fórmula:C33H50N4O8Forma y color:SolidPeso molecular:630.783trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Fórmula:C16H18O5Forma y color:SolidPeso molecular:290.315Grp94 Inhibitor-3
Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.Fórmula:C24H20ClNO4Forma y color:SolidPeso molecular:421.87Hsp70-derived octapeptide
CAS:TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.Fórmula:C36H58N8O16Pureza:98%Forma y color:SolidPeso molecular:858.89JD-13
CAS:JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.Fórmula:C25H32N4O3Pureza:99.32% - 99.69%Forma y color:White SolidPeso molecular:436.56A17 peptide
CAS:A17 peptide is an Hsp70-targeting peptide. It binds to the ATP-binding domain of Hsp70, specifically inhibiting its chaperone activity. This enhances cellular sensitivity to chemotherapeutic drugs, such as those inducing apoptosis via Cisplatin. A17 peptide is applicable in cancer chemotherapy research, including studies on multiple myeloma.Fórmula:C76H105N19O20SForma y color:SolidPeso molecular:1636.83Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Fórmula:C34H49F3N4O10Forma y color:SolidPeso molecular:730.34008HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Fórmula:C57H71N15O6Forma y color:SolidPeso molecular:1062.27HA15-Biotin
CAS:HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.Fórmula:C37H45N7O5S3Forma y color:SolidPeso molecular:763.99Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Fórmula:C24H18F3N5O3Forma y color:SolidPeso molecular:481.43HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Fórmula:C22H24N2O6SPureza:98%Forma y color:SolidPeso molecular:444.5CCT245232
CAS:CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.Fórmula:C27H23N3O4Forma y color:SolidPeso molecular:453.49PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Fórmula:C18H21IN6O2SPureza:98.31% - 99.93%Forma y color:White SolidPeso molecular:512.37Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Fórmula:C22H30N6O2SPureza:98.98%Forma y color:White SolidPeso molecular:442.58
