Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2235 productos de "Cromatina / Epigenética"
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JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Forma y color:Odour Solid3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:<p>3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.</p>Fórmula:C30H52O4Forma y color:SolidPeso molecular:476.742ACBI2
CAS:<p>ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer research.</p>Fórmula:C56H68BrFN8O5SForma y color:SolidPeso molecular:1064.16Ep300/CREBBP-IN-8
CAS:<p>Ep300/CREBBP-IN-8, IC50: 0.014/0.018 μM, potent Ep300/CREBBP inhibitor, oral, for cancer research.</p>Fórmula:C25H27F2N5O3Forma y color:SolidPeso molecular:483.51LLY-284
CAS:<p>LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.</p>Fórmula:C17H18N4O4Pureza:98%Forma y color:SolidPeso molecular:342.35Aclantate
CAS:<p>Aclantate is a nonsteroidal anti-inflammatory drug.</p>Fórmula:C15H14ClNO4SPureza:98%Forma y color:SolidPeso molecular:339.79DNMT1/HDAC-IN-1
<p>DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.</p>Forma y color:Odour SolidHDAC6-IN-53
<p>HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.</p>Forma y color:Odour SolidSAMS
CAS:<p>SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).</p>Fórmula:C74H131N29O18S2Pureza:98%Forma y color:SolidPeso molecular:1779.15Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS:<p>Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.</p>Fórmula:C88H138N20O34P2Pureza:98%Forma y color:SolidPeso molecular:2082.1PROTAC BRD4-DCAF1 degrader-1
CAS:<p>PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.</p>Fórmula:C60H64Cl2F2N8O9SForma y color:SolidPeso molecular:1182.17Ep300/CREBBP-IN-3
CAS:<p>Ep300/CREBBP-IN-3 inhibits Ep300 & CREBBP (IC50: 0.056 & 0.095 μM respectively); potential for cancer research.</p>Fórmula:C26H25F4N5O3Forma y color:SolidPeso molecular:531.50Malantide TFA
<p>Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.</p>Fórmula:C74H125F3N22O23Forma y color:SolidPeso molecular:1747.91Kiss2 peptide acetate
<p>Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).</p>Fórmula:C63H84N16O12·xC2H4O2Forma y color:SolidPeso molecular:1257.44 (free base)PROTAC SMARCA2/4-degrader-28
CAS:<p>PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.</p>Fórmula:C54H68ClN9O11S2Forma y color:SolidPeso molecular:1118.75Dot1L-IN-1 TFA
<p>Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).</p>Fórmula:C34H37ClF3N9O4SForma y color:SolidPeso molecular:760.23PRMT5-IN-11
CAS:<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Fórmula:C13H17N5O4Forma y color:SolidPeso molecular:307.31AUR1545
CAS:<p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>Fórmula:C41H50BrN9O5Pureza:98.84%Forma y color:SolidPeso molecular:828.8PROTAC BRD4 Degrader-12
CAS:<p>PROTAC BRD4 Degrader-12 targets BRD4 in PC3 cells; conjugates with STEAP1, CLL1; DC50: 0.39/0.24 nM.</p>Fórmula:C62H77F2N9O12S4Forma y color:SolidPeso molecular:1306.58JPS016
CAS:<p>JPS016: benzamide VHL E3-ligase PROTAC, degrades HDAC1/2, triggers apoptosis in HCT116 cells.</p>Fórmula:C48H63N7O8SForma y color:SolidPeso molecular:898.12
