Aurora quinasa
Los inhibidores de las quinasas Aurora se dirigen a las quinasas Aurora, una familia de quinasas de serina/treonina que desempeñan un papel crucial en la regulación de la mitosis. Estas quinasas son esenciales para la correcta alineación, segregación y citocinesis de los cromosomas durante la división celular. La actividad anormal de las quinasas Aurora puede llevar a una proliferación celular descontrolada y al cáncer. Al inhibir las quinasas Aurora, estos compuestos pueden inducir la detención del ciclo celular y la apoptosis en células cancerosas, lo que los convierte en herramientas valiosas en la investigación y terapia del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de quinasas Aurora de alta calidad para apoyar su investigación en la regulación del ciclo celular, mitosis y oncología.
Se han encontrado 116 productos para "Aurora quinasa".
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Tinengotinib
CAS:Tinengotinib is a multikinase inhibitor that targets a series of kinases , including Aurora kinases A/B, JAK1/2, FGFR1/2/3, VEGFRs, and many other kinases.Fórmula:C20H19ClN6OPureza:99.05%Forma y color:SolidPeso molecular:394.86TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFórmula:C28H32N4O3SPureza:99.02% - 99.59%Forma y color:SolidPeso molecular:504.64Ref: TM-T2709
1mg34,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg99,00€25mg192,00€50mg313,00€100mg497,00€200mg710,00€NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Fórmula:C23H30N6O2Pureza:98.33%Forma y color:SolidPeso molecular:422.52Ref: TM-T16359
2mg39,00€5mg60,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg177,00€50mg285,00€100mg414,00€200mg580,00€Centrinone
CAS:Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Fórmula:C26H25F2N7O6S2Pureza:98.76%Forma y color:SolidPeso molecular:633.65dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Fórmula:C52H53Cl2FN8O12Pureza:99.44%Forma y color:SolidPeso molecular:1071.93HLB-0532259
CAS:HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Fórmula:C40H44N8O7Forma y color:SolidPeso molecular:748.827AURKA-IN-4
CAS:AURKA-IN-4 is an AURKA inhibitor, which can inhibit the proliferation of tumor cells.Fórmula:C12H17NO3Pureza:99.98%Forma y color:Brown SolidPeso molecular:223.27Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.92% - 99.97%Forma y color:White SolidPeso molecular:587.54dAurAB2
dAurAB2 is a bifunctional PROTAC capable of effectively degrading Aurora-A and Aurora-B, with DC50 values of 59 nM and 39 nM, respectively. It reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells and is valuable for neuroblastoma research.Forma y color:Odour SolidPROTAC MPS1 degrader 1
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)Fórmula:C41H46N12O7Forma y color:SolidPeso molecular:818.88SK2187
CAS:SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.Fórmula:C45H49ClFN7O11SForma y color:SolidPeso molecular:950.43GSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Fórmula:C30H33N7OPureza:99.73%Forma y color:SolidPeso molecular:507.63JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Fórmula:C43H45ClFN7O10SForma y color:SolidPeso molecular:906.375Aurora-A ligand 1
CAS:Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.Fórmula:C21H23N5O3Forma y color:SolidPeso molecular:393.439TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Fórmula:C23H22Cl2FN5O3Pureza:99.65%Forma y color:White SolidPeso molecular:506.36Ref: TM-T34787
1mg92,00€5mg222,00€1mL*10mM (DMSO)248,00€10mg358,00€25mg710,00€50mg1.108,00€100mg1.558,00€dAURK-4
CAS:dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Fórmula:C52H52ClFN8O12Forma y color:SolidPeso molecular:1035.47SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Fórmula:C25H20FN7OPureza:99.54%Forma y color:SolidPeso molecular:453.47Ref: TM-T41256
1mg70,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg401,00€50mg567,00€100mg802,00€200mg1.099,00€CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Forma y color:SolidPROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Fórmula:C41H41N11O8SForma y color:SolidPeso molecular:847.90AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Fórmula:C28H32FN9O2Forma y color:SolidPeso molecular:545.61
