Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2242 productos de "Cromatina / Epigenética"
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Bromodomain IN-2
CAS:<p>BD-IN-1: Bromodomain inhibitor, K D 67-970nM for BRD4, CBP, etc. Antiproliferative.</p>Fórmula:C16H17ClN2OForma y color:SolidPeso molecular:288.77Zifcasiran
CAS:<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Fórmula:C737H972F20N211O349P43S8Forma y color:SolidPeso molecular:20339.13HDAC-IN-89
<p>HDAC-IN-89 is an inhibitor of HDAC1 (IC50: 0.95 nM), HDAC2 (IC50: 0.86 nM), HDAC3 (IC50: 1.06 nM), and HDAC8 (IC50: 4.24 nM). It can disrupt the cell cycle and induce apoptosis. Additionally, HDAC-IN-89 exhibits antitumor activity.</p>Forma y color:Odour SolidSphingosine (d14:1)
CAS:<p>Sphingosine (d14:1) boosts N. rileyi fungus growth, inhibits PKC, and reduces CHO cell proliferation; found in various sea creatures.</p>Fórmula:C14H29NO2Forma y color:SolidPeso molecular:243.39HIF-PHD-IN-4
<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>Forma y color:Odour SolidTDI-012804
<p>TDI-012804 is a TNKS2 inhibitor that selectively inhibits endogenous TNKS2 protein within cells. It enhances the expression of AXIN1 protein in Tnks1 heterozygous (Tnks1HET) and knockout (Tnks1KO) cells. TDI-012804 suppresses the proliferation of ApcQ1405X/Tnks1KO organoids with an EC50 of 59.1 nM and exhibits selective toxicity towards Tnks1KO AKP-G12D and AKP-G13D organoids.</p>Forma y color:Odour SolidProtein Kinase C (19-36)
CAS:Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Fórmula:C93H159N35O24Pureza:98%Forma y color:SolidPeso molecular:2151.48PIM-IN-1
CAS:<p>PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC 50 = 61 nM; pS6, EC 50 = 71 nM).</p>Fórmula:C15H18ClFN4OForma y color:SolidPeso molecular:324.78Lys-CoA TFA
<p>Lys-CoA TFA: p300 HAT inhibitor, IC50 50-500 nM, >100x selective vs PCAF, inhibits p300-dependent transcription.</p>Fórmula:C33H54F3N10O21P3SForma y color:SolidPeso molecular:1108.82JAK1/TYK2-IN-1
CAS:<p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>Fórmula:C18H20F3N7OForma y color:SolidPeso molecular:407.401C8 Dihydroceramide
CAS:<p>C8 Dihydroceramide is a control for C8 Ceramide, a bioactive, cell-permeable, chemotherapeutic agent that boosts T cell responses and slightly activates PKC.</p>Fórmula:C26H53NO3Forma y color:SolidPeso molecular:427.70FTX-6058 hydrochloride
CAS:<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Fórmula:C22H19ClFN5O2Forma y color:SolidPeso molecular:439.87PARP/EZH2-IN-1
CAS:<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Fórmula:C43H41FN8O5Forma y color:SolidPeso molecular:768.85UNC6349 (Ket2)
<p>UNC6349 (Ket2), a ligand containing diethyllysine (Ket2), effectively binds to wild-type CBX5 with a dissociation constant (K D) of 3.2 μM [1].</p>Fórmula:C41H57N7O11Forma y color:SolidPeso molecular:823.93Protein kinase C α peptide TFA
CAS:<p>Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.</p>Fórmula:C68H115F3N24O26SForma y color:SolidPeso molecular:1773.85C 21
CAS:<p>PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.</p>Fórmula:C90H161ClN36O24Pureza:98%Forma y color:SolidPeso molecular:2166.94SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Fórmula:C155H256N48O40Pureza:98%Forma y color:SolidPeso molecular:3432.05HDAC8-IN-6
<p>HDAC8-IN-6 (compound 3) is a potent inhibitor of HDAC8 with an IC50 of 5.1 μM and exhibits cytotoxicity.</p>Fórmula:C19H18IN3O2Peso molecular:447.04437GXH-II-052
<p>GXH-II-052: Potent BET inhibitor, binds BRD4/BRDT (Kd 0.6-28 nM), anti-proliferative, reduces c-Myc expression.</p>Fórmula:C62H76Cl2F2N14O11S2Forma y color:SolidPeso molecular:1366.39RBN012811
CAS:<p>RBN012811 is a PROTAC specifically targeting PARP14.</p>Fórmula:C40H49FN8O6SForma y color:SolidPeso molecular:788.93
