Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2252 productos de "Cromatina / Epigenética"
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CAY10398
CAS:<p>CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).</p>Fórmula:C15H23N3O3Forma y color:SolidPeso molecular:293.367KDM4-IN-2
CAS:<p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>Fórmula:C25H26N6OPureza:98%Forma y color:SolidPeso molecular:426.51JAK-IN-31
CAS:<p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>Fórmula:C21H19N7O2S2Pureza:98%Forma y color:SolidPeso molecular:465.55KDM5-IN-1
CAS:<p>KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.</p>Fórmula:C17H20N6OPureza:99.50%Forma y color:SolidPeso molecular:324.38EZH2-IN-14
CAS:<p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.</p>Fórmula:C31H39N7O2Forma y color:SolidPeso molecular:541.69TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Forma y color:SolidPeso molecular:526.51PIM-IN-2
CAS:<p>PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .</p>Fórmula:C19H22N4O2Pureza:98%Forma y color:SolidPeso molecular:338.4dBRD4-BD1
CAS:<p>dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.</p>Fórmula:C50H53F3N8O9Forma y color:SolidPeso molecular:967AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Fórmula:C25H24ClNO9Pureza:98%Forma y color:SolidPeso molecular:517.91Tubulin/JAK2-IN-1
CAS:<p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>Fórmula:C22H20N6O3Forma y color:SolidPeso molecular:416.43GNE-049
CAS:<p>GNE-049 is a highly selective CBP inhibitor (IC50=1.1 nM) that blocks prostate cancer cell proliferation.</p>Fórmula:C27H32F2N6O2Pureza:98.67%Forma y color:SolidPeso molecular:510.58Itacnosertib (hydrocholide)
CAS:<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Fórmula:C26H29ClN8OForma y color:SolidPeso molecular:505.01WM-586
CAS:<p>WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.</p>Fórmula:C20H20F3N5O3SPureza:98%Forma y color:SolidPeso molecular:467.47GNE-955
CAS:<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Fórmula:C22H24N8OPureza:98%Forma y color:SolidPeso molecular:416.48CW 008
CAS:<p>CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.</p>Fórmula:C21H14F2N6O2Pureza:97.39%Forma y color:SolidPeso molecular:420.37GSK4028
CAS:<p>GSK4028 is the enantiomeric negative control of GSK4027, a PCAF/GCN5 bromodomain chemical probe, with a pIC50 of 4.9 in a TR-FRET assay.</p>Fórmula:C17H21BrN4OForma y color:SolidPeso molecular:377.28SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Fórmula:C28H31ClN4O3Pureza:98%Forma y color:SolidPeso molecular:507.02JG-2016
CAS:<p>JG-2016, as a histone acetyltransferase 1 inhibitor, inhibits growth of human cancer cell lines and inhibits enzymatic activity in cellulose.</p>Fórmula:C18H21ClN4O3Pureza:99.00% - 99.37%Forma y color:SolidPeso molecular:376.84JBI-589
CAS:<p>JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.</p>Fórmula:C29H28FN5OForma y color:SolidPeso molecular:481.56PARP-2-IN-1
CAS:<p>PARP-2-IN-1 is a potent and selective inhibitor of PARP-2(IC50 of 11.5 nM).</p>Fórmula:C21H19F4N5O3Pureza:98%Forma y color:SolidPeso molecular:465.4
