Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2235 productos de "Cromatina / Epigenética"
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JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Forma y color:Odour Solid3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol
CAS:<p>3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a compound that functions as a SIRT1 activator, effectively enhancing SIRT1 activity.</p>Fórmula:C30H52O4Forma y color:SolidPeso molecular:476.742PARP/EZH2-IN-1
CAS:<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Fórmula:C43H41FN8O5Forma y color:SolidPeso molecular:768.85PARP1-IN-35
<p>PARP1-IN-35 (compound T26) is a selective, orally active PARP1 inhibitor that can cross the blood-brain barrier, with IC50 values of 0.2 nM for PARP1 and 122 nM for PARP2. It exhibits antiproliferative and anticancer activities and holds potential for breast cancer research.</p>Fórmula:C22H21N5OForma y color:SolidPeso molecular:371.435PRO-HD2
<p>PRO-HD2 is a selective, PROTAC-based degrader of HDAC6 [1].</p>Pureza:98%Forma y color:Odour SolidPulrodemstat
CAS:<p>Pulrodemstat (CC-90011) is an LSD1 inhibitor with anticancer and antitumor activity, inhibiting proliferation and migration of HNSCC cells.</p>Fórmula:C24H23F2N5O2Pureza:98.11% - 98.87%Forma y color:SolidPeso molecular:451.47Hyp-dBET1
<p>Hyp-dBET1 is a PROTAC degrader targeting BRD4, with an IC50 value of 3.4 μM in MDA-MB-231 cells. Under hypoxic conditions, Hyp-dBET1 becomes active, recruiting E3 ubiquitin ligase, and facilitates the degradation of BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable in anti-cancer research.</p>Forma y color:Odour SolidHDAC6-IN-53
<p>HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.</p>Forma y color:Odour SolidSAMS
CAS:<p>SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).</p>Fórmula:C74H131N29O18S2Pureza:98%Forma y color:SolidPeso molecular:1779.15Neuropeptide DF2
CAS:<p>Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.</p>Fórmula:C44H67N15O10Pureza:98%Forma y color:SolidPeso molecular:966.1SIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Fórmula:C14H16N2OPureza:99.58%Forma y color:SolidPeso molecular:228.29ZIP
CAS:<p>Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.</p>Fórmula:C90H154N30O17Pureza:98%Forma y color:SolidPeso molecular:1928.4XY-06-007
CAS:<p>XY-06-007: Selective PROTAC BRD4 BD1 L94V degrader with 10 nM DC50, 6h & clean off-target profile; good for in vivo studies.</p>Fórmula:C41H41ClN8O8Forma y color:SolidPeso molecular:809.27PROTAC BRD4 Degrader-29
<p>PROTAC BRD4 Degrader-29 (compound 7a) is a potent BRD4 PROTAC degrader with a DC50 of 89.4 nM, playing a significant role in cancer research.</p>Fórmula:C58H61ClN10O9S2Forma y color:SolidPeso molecular:1141.75Aurora-A ligand 1
CAS:<p>Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.</p>Fórmula:C21H23N5O3Forma y color:SolidPeso molecular:393.439RX-37
CAS:<p>RX-37, a potent BET inhibitor (Ki: 3.2-24.7 nM for BRD2/3/4), selectively hinders growth in leukemia cells with MLL1 gene rearrangement.</p>Fórmula:C24H23N5O2Pureza:98%Forma y color:SolidPeso molecular:413.47PROTAC SMARCA2/4-degrader-28
CAS:<p>PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.</p>Fórmula:C54H68ClN9O11S2Forma y color:SolidPeso molecular:1118.75PRMT5-IN-14
CAS:<p>PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.</p>Fórmula:C18H18Cl2N4O4Forma y color:SolidPeso molecular:425.27BB-Cl-Amidine TFA
<p>BB-Cl-Amidine (TFA) is an inhibitor of peptidylarginine deiminase (PAD).</p>Forma y color:Odour SolidFluorescein-NAD+
<p>Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.</p>Forma y color:Solid[Ala113]MBP(104-118)
CAS:<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).</p>Fórmula:C67H104N20O19Pureza:98%Forma y color:SolidPeso molecular:1493.68LSD1-IN-38
<p>LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 1.2 nM. It effectively inhibits the proliferation of cancer cells MV4-11, Kasumi-1, and NCI-H526 with IC50 values of 5, 4, and 11 nM, respectively. Furthermore, LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 μM and induces differentiation in MV4-11 cells. In mouse models, this compound demonstrates antitumor activity.</p>Fórmula:C30H29F4N5Forma y color:SolidPeso molecular:535.578BRD4 Inhibitor-16
<p>BRD4 Inhibitor-16 (Compound 4) is a potent suppressor of BRD4 linked to cancer, aiding in research of BRD4-related treatments.</p>Fórmula:C42H43N7O8SForma y color:SolidPeso molecular:805.9AUR1545
CAS:<p>AUR1545 is a selective KAT2A/KAT2B degradator exhibiting inhibitory activity against cancer models including AML, SCLC, and NEPC, and suppressing tumour growth in the NCI-H1048 xenograft model.</p>Fórmula:C41H50BrN9O5Pureza:98.84%Forma y color:SolidPeso molecular:828.8PROTAC BRD4-binding moiety 1
CAS:<p>BRD4-binding moiety 1 links to cereblon, forming a PROTAC that degrades BRD4 efficiently.</p>Fórmula:C23H21N3O2Pureza:98%Forma y color:SolidPeso molecular:371.43[Ala107]MBP(104-118)
CAS:<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).</p>Fórmula:C67H104N20O19Pureza:98%Forma y color:SolidPeso molecular:1493.68PROTAC BRD4 Degrader-15
CAS:<p>PROTAC BRD4 Degrader-15 targets von Hippel-Lindau and BRD4 with IC50s 7.2/8.1 nM and degrades BRD4 in cancer cells.</p>Fórmula:C57H62F2N10O10S2Forma y color:SolidPeso molecular:1149.3PARP1-IN-6
CAS:<p>PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μM</p>Fórmula:C16H11FN2OForma y color:SolidPeso molecular:266.27Bromodomain IN-2
CAS:<p>BD-IN-1: Bromodomain inhibitor, K D 67-970nM for BRD4, CBP, etc. Antiproliferative.</p>Fórmula:C16H17ClN2OForma y color:SolidPeso molecular:288.77OKI-006
CAS:<p>OKI-006 is an oral HDAC inhibitor with potential for cancer research, derived from largazole.</p>Fórmula:C21H30N4O5S2Forma y color:SolidPeso molecular:482.62(R)-SKBG-1
CAS:<p>(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNA</p>Fórmula:C22H26ClN3O6SPureza:97.25%Forma y color:SolidPeso molecular:495.98Protein Kinase C (19-31)
CAS:<p>Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.</p>Fórmula:C67H118N26O16Pureza:98%Forma y color:Lyophilized PowderPeso molecular:1543.82PROTAC BRD4 Degrader-7
CAS:<p>PROTAC BRD4 Degrader-7, from patent WO2020055976A1, has IC50 of 15.5 nM (BD1) & 12.3 nM (BD2).</p>Fórmula:C26H29N5O2SForma y color:SolidPeso molecular:475.61LH168
<p>LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.</p>Fórmula:C29H31F3N6O2SForma y color:SolidPeso molecular:584.66QA-68
<p>QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.</p>Fórmula:C61H72N10O10S2Forma y color:SolidPeso molecular:1169.42SJ10542
CAS:<p>SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.</p>Fórmula:C41H46N12O5SForma y color:SolidPeso molecular:818.95Zifcasiran
CAS:<p>Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.</p>Fórmula:C737H972F20N211O349P43S8Forma y color:SolidPeso molecular:20339.13Tanshinol borneol ester
CAS:<p>Tanshinol borneol ester stimulates angiogenesis via Akt/MAPK pathways and has anti-ischemic, anti-atherosclerosis effects.</p>Fórmula:C19H26O5Forma y color:SolidPeso molecular:334.41PROTAC PARP1 degrader-4
<p>PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader, demonstrating DC50 values of 180 nM and 240 nM in T47D and MDA-MB-231 cell lines, respectively. It facilitates the ubiquitination and degradation of PARP1 and inhibits its enzymatic activity without causing significant DNA trapping effects. Additionally, PROTAC PARP1 degrader-4 can inhibit tumors with BRCA gene mutations while having minimal impact on the growth of normal cells.</p>Fórmula:C51H62FN7O6SForma y color:SolidPeso molecular:920.145Thalidomide-NH-CBP/p300 ligand 2
CAS:<p>Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).</p>Fórmula:C48H57F2N11O6Forma y color:SolidPeso molecular:922.052AS2553627
CAS:<p>AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.</p>Fórmula:C18H19N5OForma y color:SolidPeso molecular:321.38PROTAC HDAC6 degrader 4
<p>PROTAC HDAC6 degrader4 (Compound 17c) is a PROTAC that targets and degrades HDAC6, with a DC50 of 14 nM. It exhibits inhibitory activity against HDAC1, HDAC2, HDAC3, and HDAC6, with IC50 values of 2.2, 2.37, 0.61, and 0.295 μM, respectively. [Pink: ligand for target protein HDAC6 ligand-3; Black: linker; Blue: ligand for cereblon E3 ligase]</p>Fórmula:C39H42FN9O7Forma y color:SolidPeso molecular:767.81TCIP3
CAS:<p>TCIP3 is a bivalent molecular glue (molecular glue) that can simultaneously bind to both p300/CBP and BCL6. It redirects p300 and CBP to activate programmed cell death genes, which are typically repressed by the oncogenic driver BCL6. TCIP3 is useful for studying diffuse large B-cell lymphoma (DLBCL) and is not toxic to untransformed tonsil lymphocytes or fibroblasts.</p>Fórmula:C58H71ClF2N16O7Forma y color:SolidPeso molecular:1177.74PROTAC BRD4-DCAF1 degrader-1
CAS:<p>PROTACBRD4-DCAF1 degrader-1 (I-907) is a PROTAC degrader targeting BRD4-DCAF1, exhibiting a DC50 range of 10~100 nM.</p>Fórmula:C60H64Cl2F2N8O9SForma y color:SolidPeso molecular:1182.17DNMT1/HDAC-IN-1
<p>DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.</p>Forma y color:Odour SolidCARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Fórmula:C27H35ClN6O3Forma y color:SolidPeso molecular:527.06HDAC11-IN-1
<p>HDAC11-IN-1 (Compound 14-NC6OH) is a macrocyclic inhibitor that selectively targets HDAC11 with a Ki of 40 nM. It demonstrates effective cell permeability and suppresses the expression of YAP1 and SOX2.</p>Fórmula:C43H63F3N6O6S2Forma y color:SolidPeso molecular:881.12ZSNI-21
<p>ZSNI-21 is a dual inhibitor targeting ADAM17 and HDAC2. It effectively suppresses the proliferation of Bel-7402 cells and exhibits significant anti-metastatic properties against HCC-LM3 cells, making it a promising candidate for hepatocellular carcinoma (HCC) research.</p>Fórmula:C26H25N3O5Forma y color:SolidPeso molecular:459.49UNC6349 (Ket2)
<p>UNC6349 (Ket2), a ligand containing diethyllysine (Ket2), effectively binds to wild-type CBX5 with a dissociation constant (K D) of 3.2 μM [1].</p>Fórmula:C41H57N7O11Forma y color:SolidPeso molecular:823.93R8-T198wt
CAS:<p>Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.</p>Fórmula:C111H211N59O26SPureza:98%Forma y color:SolidPeso molecular:2820.33
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