Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2235 productos de "Cromatina / Epigenética"
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AZD-1897
CAS:<p>AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.</p>Fórmula:C18H23N3O3SPureza:99.49%Forma y color:SolidPeso molecular:361.46PNZ5
CAS:<p>PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation</p>Fórmula:C20H18N2O2Pureza:99.51% - 99.61%Forma y color:SolidPeso molecular:318.37KBH-A42
CAS:<p>KBH-A42 is an inhibitor of histone deacetylase.</p>Fórmula:C17H22N2O3Pureza:98%Forma y color:SolidPeso molecular:302.37JAK3/BTK-IN-1
CAS:<p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>Fórmula:C25H28N8OPureza:97.89%Forma y color:SolidPeso molecular:456.54DS-437
CAS:<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Fórmula:C15H23N7O4SPureza:98%Forma y color:SolidPeso molecular:397.45JAK-IN-10
CAS:<p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>Fórmula:C20H18FN5O3SPureza:99.53%Forma y color:SolidPeso molecular:427.45(2R/S)-6-PNG
CAS:<p>(2R/S)-6-PNG (6-Prenylnaringenin) from hops is a natural histone deacetylase inhibitor that blocks T-type calcium channels reducing neurogenicity in mice.</p>Fórmula:C20H20O5Pureza:98%Forma y color:SolidPeso molecular:340.37SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Fórmula:C16H11ClN2O5SPureza:98.99%Forma y color:SolidPeso molecular:378.79SIRT5 inhibitor 5
CAS:<p>SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.</p>Fórmula:C21H14ClN3O3SPureza:99.33%Forma y color:SolidPeso molecular:423.87EPZ032597
CAS:<p>EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancer</p>Fórmula:C20H23N7OPureza:99.70%Forma y color:SolidPeso molecular:377.44KP-302
CAS:<p>KP-302 is a selective PAD inhibitor, reversing physical disability in multiple sclerosis (MS) mice and clearing T-cell infiltration in the brain.</p>Fórmula:C20H23N5O2Pureza:99.77%Forma y color:SolidPeso molecular:365.43JAK-IN-28
CAS:<p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>Fórmula:C20H18ClN7OPureza:98%Forma y color:SolidPeso molecular:407.86Valemetostat tosylate
CAS:<p>Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.</p>Fórmula:C33H42ClN3O7SPureza:98%Forma y color:SolidPeso molecular:660.22BET-IN-7
CAS:<p>BET-IN-7 is a potent BET inhibitor with a Ki of 12.27 μM and Kd of 89.3 μM, useful in sepsis research.</p>Fórmula:C18H12ClN3OSForma y color:SolidPeso molecular:353.83Furamidine
CAS:<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Fórmula:C18H16N4OPureza:98%Forma y color:SolidPeso molecular:304.35GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Fórmula:C17H17FN2O5Pureza:98%Forma y color:SolidPeso molecular:348.33Ilorasertib hydrochloride
CAS:<p>Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:</p>Fórmula:C25H22ClFN6O2SPureza:98.45%Forma y color:SolidPeso molecular:525JAK-IN-14
CAS:<p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>Fórmula:C19H15FN4OPureza:98.27%Forma y color:SolidPeso molecular:334.35Aurora kinase inhibitor-10
CAS:<p>Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.</p>Fórmula:C21H19F5N6O4SForma y color:SolidPeso molecular:546.47MT477
CAS:<p>MT477 inhibits PKC-α, impairs Ras/ERK1/2 phosphorylation, induces apoptosis, and reduces proliferation in various cancer cells.</p>Fórmula:C31H30N2O12S3Forma y color:SolidPeso molecular:718.77Rucaparib camsylate
CAS:<p>Rucaparib camsylate, a PARP-1, -2, -3 inhibitor (Ki=1.4 nM for PARP-1) & H6PD blocker, may treat resistant prostate cancer.</p>Fórmula:C19H18FN3O·xC10H16O4SForma y color:SolidHIF-PHD-IN-2
CAS:<p>HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].</p>Fórmula:C17H15N5O3SForma y color:SolidPeso molecular:369.4dWIZ-1
CAS:<p>dWIZ-1 ((rac)-dWIZ-1) is a potent WIZ molecular gel degrader tha induction of haemoglobin fetalis (HbF) in erythroblasts, sickle cell disease (SCD).</p>Fórmula:C22H29N3O4Pureza:92.87% - 92.87%Forma y color:SolidPeso molecular:399.48Y08284
CAS:<p>Y08284: selective CBP bromodomain inhibitor, IC50: 4.21 nM, oral. Halts prostate cancer cell growth; anti-tumor.</p>Fórmula:C26H25FN4O4Forma y color:SolidPeso molecular:476.5HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Fórmula:C16H11FN4O2SForma y color:SolidPeso molecular:342.35Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Forma y color:SolidPeso molecular:248.23Bizine
CAS:<p>Bizine, a Phenelzine analogue, selectively inhibits LSD1 (Ki=59 nM), modulates histone methylation in cancer, and may have neuroprotective uses.</p>Fórmula:C18H23N3OForma y color:SolidPeso molecular:297.39Thi-DPPY
CAS:<p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>Fórmula:C28H28ClN5O4SForma y color:SolidPeso molecular:566.07HDAC3-IN-T247
CAS:<p>HDAC3-IN-T247 (HDAC3 inhibitor T247) is a histone deacetylase 3 (HDAC3) inhibitor with antiviral activity that inhibits the proliferation of cancer cells.</p>Fórmula:C21H19N5OSPureza:98.11% - 98.94%Forma y color:SolidPeso molecular:389.47SIRT1-IN-2
CAS:<p>SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].</p>Fórmula:C13H15ClN2OForma y color:SolidPeso molecular:250.72IDO1 and HDAC1 Inhibitor
CAS:<p>IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).</p>Fórmula:C25H22BrFN8O4Pureza:98%Forma y color:SolidPeso molecular:597.4HDAC-IN-49
<p>HDAC-IN-49: potent, broad HDAC inhibitor; IC50s: 10-1880 nM for HDAC1-6; strong anti-leukemic, low toxicity to healthy cells.</p>Fórmula:C26H27FN4O4Forma y color:SolidPeso molecular:478.52CYP51/HDAC-IN-1
CAS:<p>Orally active CYP51/HDAC-IN-1 dual inhibitor targets virulence factors and resistance genes; effective against Candidiasis and Cryptococcal meningitis.</p>Fórmula:C30H40F2N6O4Forma y color:SolidPeso molecular:586.67TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Fórmula:C13H11F3O4Pureza:98.07%Forma y color:SolidPeso molecular:288.22Sirt1/2-IN-1
CAS:<p>Sirt1/2-IN-1 inhibits SIRT1 (IC50: 1.81 μg/mL) and SIRT2 (2.10 μg/mL), less on SIRT3 (20.5 μg/mL), with anticancer properties.</p>Fórmula:C22H13ClN2OS2Forma y color:SolidPeso molecular:420.93HDAC6-IN-15
<p>HDAC6-IN-15: selective HDAC6 inhibitor, IC50 of 38.2 nM, for cancer and neurodegenerative research.</p>Fórmula:C25H28FFeN3O2Forma y color:SolidPeso molecular:477.35M133
CAS:<p>M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.</p>Fórmula:C23H24N4OS2Forma y color:SolidPeso molecular:436.59CBHA
CAS:<p>m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.</p>Fórmula:C10H10N2O4Forma y color:SolidPeso molecular:222.2Peficitinib hydrobromide
CAS:<p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>Fórmula:C18H23BrN4O2Forma y color:SolidPeso molecular:407.312PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Fórmula:C17H11ClN4OPureza:98.81%Forma y color:SolidPeso molecular:322.75MI-2-2
CAS:<p>MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.</p>Fórmula:C17H20F3N5S2Pureza:99.65%Forma y color:SolidPeso molecular:415.5OUL245
CAS:<p>OUL245: A selective PARP2 inhibitor (IC50=44nM), also inhibits other PARPs/TNKS (IC50=2.9-8.8μM).</p>Fórmula:C8H5N3OSForma y color:SolidPeso molecular:191.21YM-53601
CAS:<p>YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.</p>Fórmula:C21H22ClFN2OPureza:99.65%Forma y color:SolidPeso molecular:372.86IACS-9571
CAS:<p>IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).</p>Fórmula:C32H42N4O8SPureza:98%Forma y color:SolidPeso molecular:642.76Tyk2-IN-5
CAS:<p>Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).</p>Fórmula:C21H19FN8O2Pureza:98%Forma y color:SolidPeso molecular:434.43CPI703
CAS:<p>CPI703 is a novel potent and specific CBP/EP300 bromodomain inhibitor.</p>Fórmula:C17H22N4OPureza:98%Forma y color:SolidPeso molecular:298.38JAK3/BTK-IN-2
CAS:<p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>Fórmula:C25H32N8O2Pureza:99.64% - 99.87%Forma y color:SolidPeso molecular:476.57Bromodomain IN-1
CAS:<p>Bromodomain IN-1 is an inhibitor of Bromodomain.</p>Fórmula:C22H23ClN4O3SPureza:98%Forma y color:SolidPeso molecular:458.962′-Deoxy-5-nitrocytidine
CAS:<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Fórmula:C9H12N4O6Forma y color:SolidPeso molecular:272.216-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Fórmula:C9H14N4O5Pureza:98%Forma y color:SolidPeso molecular:258.23
