Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2235 productos de "Cromatina / Epigenética"
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SB-284851-BT
CAS:<p>SB-284851-BT: BRD4/p38α/BRDT inhibitor; IC50: BRD4-BD1 1.7µM, BRDT 18µM, BRD4 3.7µM; Kd p38α 0.47nM; reduces IL-8, affects c-Myc/NF-κB.</p>Fórmula:C26H26FN5OForma y color:SolidPeso molecular:443.52BET-BAY 002 (S enantiomer)
CAS:<p>The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins).</p>Fórmula:C22H18ClN5OPureza:98%Forma y color:SolidPeso molecular:403.86PKC-IN-4
CAS:<p>PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM.</p>Fórmula:C21H25N5SForma y color:SolidPeso molecular:379.52CD161
CAS:<p>CD161: powerful, selective oral BET inhibitor; IC50: 28.2 nM (BRD4 BD1), 7.2 nM (BRD4 BD2); strong anticancer properties.</p>Fórmula:C26H21N5O2Pureza:98%Forma y color:SolidPeso molecular:435.48YF479
CAS:<p>YF479 is an inhibitor of histone deacetylase that acts by inhibiting breast tumor growth, metastasis, and recurrence.</p>Fórmula:C22H27BrN2O5Pureza:98%Forma y color:SolidPeso molecular:479.36TC-E 5001
CAS:<p>dual tankyrase (TNKS) inhibitor</p>Fórmula:C20H19N5O3SPureza:98%Forma y color:SolidPeso molecular:409.46DC-CPin7
CAS:<p>DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1].</p>Fórmula:C19H22N2O5Forma y color:SolidPeso molecular:358.39OICR-0547
CAS:<p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>Fórmula:C28H29F3N4O4Pureza:98%Forma y color:SolidPeso molecular:542.55HIF-1α inhibitor-1
CAS:<p>HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.</p>Fórmula:C15H11N3O4Forma y color:SolidPeso molecular:297.27Cercosporamide
CAS:<p>Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.</p>Fórmula:C16H13NO7Pureza:98%Forma y color:SolidPeso molecular:331.28Bisindolylmaleimide II
CAS:<p>protein kinase C (PKC) inhibitor</p>Fórmula:C27H26N4O2Pureza:98%Forma y color:SolidPeso molecular:438.52LSD1-IN-12
CAS:<p>LSD1-IN-12 (compound 2) is an effective inhibitor of LSD1, demonstrating inhibitory Ki values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B</p>Fórmula:C16H16N2OForma y color:SolidPeso molecular:252.31OM-137
CAS:<p>OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.</p>Fórmula:C13H14N4O3SForma y color:SolidPeso molecular:306.34SRTCX1002
CAS:<p>SRTCX1002 is a SIRT1 Activator Suppressing Inflammatory Responses through Promotion of p65 Deacetylation and NF-κB Activity inhibitor.</p>Fórmula:C21H19N5O2SPureza:98%Forma y color:SolidPeso molecular:405.47AMPK activator 6
CAS:<p>AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.</p>Fórmula:C25H28O5Forma y color:SolidPeso molecular:408.49ZLD1039
CAS:<p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>Fórmula:C36H48N6O3Pureza:99.5%Forma y color:SolidPeso molecular:612.8PU141
CAS:<p>PU141 is a novel inhibitor of histone acetyltransferase (HAT).</p>Fórmula:C14H9F3N2OSPureza:98%Forma y color:SolidPeso molecular:310.29CHIC35
CAS:<p>CHIC-35 is a selective deacetylase SIRT1 inhibitor.</p>Fórmula:C14H15ClN2OForma y color:SolidPeso molecular:262.73OTS186935 trihydrochloride
CAS:<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Fórmula:C25H29Cl4N5O2Pureza:98%Forma y color:SolidPeso molecular:573.34GNA002
CAS:<p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>Fórmula:C42H55NO8Pureza:98%Forma y color:SolidPeso molecular:701.89ET-JQ1-OH
CAS:<p>ET-JQ1-OH is an allele-specific BET inhibitor.</p>Fórmula:C21H21ClN4O2SForma y color:SolidPeso molecular:428.93SMTIN-T140
CAS:<p>SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.</p>Fórmula:C36H34BrClFN5OPPureza:98%Forma y color:SolidPeso molecular:718.02F5446
CAS:<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Fórmula:C26H17ClN2O8SPureza:98.56%Forma y color:SolidPeso molecular:552.94MicroRNA-21-IN-2
CAS:<p>MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.</p>Fórmula:C17H15N3O3SPureza:99.2%Forma y color:SolidPeso molecular:341.38CX-6258
CAS:<p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>Fórmula:C26H24ClN3O3Pureza:97.46%Forma y color:SolidPeso molecular:461.94BAY1238097
CAS:<p>BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.</p>Fórmula:C25H33N5O3Pureza:98.1% - 98.79%Forma y color:SolidPeso molecular:451.56EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Fórmula:C27H28ClN5O2Pureza:98%Forma y color:SolidPeso molecular:490CSV0C018875
CAS:<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Fórmula:C18H17ClN2OForma y color:SolidPeso molecular:312.79SPV106
CAS:<p>SPV106 is a ligand of lysine acetyltransferases (KATs).</p>Fórmula:C22H40O4Pureza:98%Forma y color:SolidPeso molecular:368.55BIX-01338 hydrate
CAS:<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Fórmula:C32H26F3N3O7Pureza:98%Forma y color:SolidPeso molecular:621.56(2R,5S)-Ritlecitinib
CAS:<p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>Fórmula:C15H19N5OForma y color:SolidPeso molecular:285.34PI3K/Akt/CREB activator 1
CAS:<p>PI3K/Akt/CREB activator 1 (AE-18) is an iNOS inhibitor that can be used to study vascular dementia and Parkinson's.</p>Fórmula:C19H15F4NO3Forma y color:SolidPeso molecular:381.32Povorcitinib
CAS:<p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>Fórmula:C23H22F5N7OForma y color:SolidPeso molecular:507.469JAK3-IN-1
CAS:<p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>Fórmula:C26H30ClN7O2Forma y color:SolidPeso molecular:508.02SRTCX1003
CAS:<p>SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.</p>Fórmula:C23H23N5O3SForma y color:SolidPeso molecular:449.53Aurora Kinases-IN-3
CAS:<p>Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.</p>Fórmula:C20H16F3N3O4Forma y color:SolidPeso molecular:419.35PBRM1-BD2-IN-6
CAS:<p>PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.</p>Fórmula:C16H15ClN2OForma y color:SolidPeso molecular:286.76CK2/PIM1-IN-1
CAS:<p>CK2/PIM1-IN-1 inhibits CK2 & PIM1 (IC50s: 3.787 & 4.327 μM), aimed for cancer research.</p>Fórmula:C15H9NO4S2Pureza:98%Forma y color:SolidPeso molecular:331.37HDAC3 Inhibitor
CAS:<p>HDAC3 inhibitor: allosteric, Ki=0.16 nM, favors HDAC3 over HDAC1/2, targets specific leukemia cells, EC50=36.37-151.7 nM.</p>Fórmula:C20H23N3O2Forma y color:SolidPeso molecular:337.42AMPK activator 8
CAS:<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Fórmula:C25H21ClN2O6Forma y color:SolidPeso molecular:480.9RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Fórmula:C28H28N6O4SForma y color:SolidPeso molecular:544.62KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Fórmula:C26H27NO5SForma y color:SolidPeso molecular:465.56SIRT2-IN-10
CAS:<p>SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.</p>Fórmula:C28H21N5OSForma y color:SolidPeso molecular:475.56SIRT5 inhibitor 4
CAS:<p>SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.</p>Fórmula:C18H15N3O4SPureza:99.97%Forma y color:SolidPeso molecular:369.39KDM5-C49
CAS:<p>KDM5-C49 is a potent and selective inhibitor of KDM5, which regulates cell proliferation and stem cell self-renewal and differentiation.</p>Fórmula:C15H24N4O3Pureza:98%Forma y color:SolidPeso molecular:308.38Dot1L-IN-2
CAS:<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Fórmula:C27H24N8OPureza:98%Forma y color:SolidPeso molecular:476.53CMP-5 hydrochloride
CAS:<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Fórmula:C21H22ClN3Pureza:98%Forma y color:SolidPeso molecular:351.87UMB-136
CAS:<p>UMB-136 is a bromodomain BRD4 inhibitor that acts by significantly inducing HIV-1 reactivation.</p>Fórmula:C24H27N5O2Pureza:98%Forma y color:SolidPeso molecular:417.5BRM/BRG1 ATP Inhibitor-3
CAS:<p>BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.</p>Fórmula:C26H25N5O2S2Forma y color:SolidPeso molecular:503.64OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Fórmula:C25H26ClN5O2Pureza:98%Forma y color:SolidPeso molecular:463.96
