Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2238 productos de "Cromatina / Epigenética"
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KCN1
CAS:<p>KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.</p>Fórmula:C26H27NO5SForma y color:SolidPeso molecular:465.56TyK2-IN-2
CAS:<p>TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).</p>Fórmula:C16H18N6OPureza:98%Forma y color:SolidPeso molecular:310.35SRI-42127
CAS:<p>SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR that inhibits tumor growth and reduces neuropathic pain following nerve injury.</p>Fórmula:C19H20N6OPureza:99.66%Forma y color:SolidPeso molecular:348.4SIRT5 inhibitor 6
CAS:<p>SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.</p>Fórmula:C21H28N6O4SPureza:99.84%Forma y color:SolidPeso molecular:460.55SIRT2-IN-10
CAS:<p>SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.</p>Fórmula:C28H21N5OSForma y color:SolidPeso molecular:475.56CTX-0124143
CAS:<p>CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.</p>Fórmula:C17H13FN2O3SPureza:99.16%Forma y color:SolidPeso molecular:344.36Dot1L-IN-2
CAS:<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Fórmula:C27H24N8OPureza:98%Forma y color:SolidPeso molecular:476.53BRM/BRG1 ATP Inhibitor-3
CAS:<p>BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.</p>Fórmula:C26H25N5O2S2Forma y color:SolidPeso molecular:503.64OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Fórmula:C25H26ClN5O2Pureza:98%Forma y color:SolidPeso molecular:463.96RSC-133
CAS:<p>promotes the reprogramming of human somatic cells to pluripotent stem cells</p>Fórmula:C18H15N3O2Pureza:98%Forma y color:SolidPeso molecular:305.33PRMT5-IN-C17
CAS:<p>PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.</p>Fórmula:C18H17N3O4SForma y color:SolidPeso molecular:371.41NSD3-IN-2
CAS:<p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>Fórmula:C17H15N5OSForma y color:SolidPeso molecular:337.45WKS
CAS:<p>5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.</p>Fórmula:C24H36ClN5O2Pureza:98%Forma y color:SolidPeso molecular:462.03NSD3-IN-3
CAS:<p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>Fórmula:C15H17N5O2SForma y color:SolidPeso molecular:331.39CL67
CAS:<p>CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.</p>Fórmula:C38H42N10O2Forma y color:SolidPeso molecular:670.81NC-III-49-1
CAS:<p>NC-III-49-1: potent BET inhibitor, binds BRD4/BRDT, inhibits cell growth, reduces c-Myc expression.</p>Fórmula:C44H50N4O11S2Forma y color:SoildPeso molecular:875.02HDAC-IN-44
CAS:<p>HDAC-IN-44 is an HDAC inhibitor (IC50: 61.2 nM) with strong anti-cancer effects.</p>Fórmula:C26H27BrN4O4Forma y color:SolidPeso molecular:539.42PDAT
CAS:<p>PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.</p>Fórmula:C15H23N3Pureza:98%Forma y color:SolidPeso molecular:245.36TM6008
CAS:<p>TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.</p>Fórmula:C21H17N5O3Pureza:98%Forma y color:SolidPeso molecular:387.39BET bromodomain inhibitor 2
CAS:<p>BET bromodomain inhibitor 2 is a potent inhibitor of the BET-type bromodomain (IC50: 14.1 μM).</p>Fórmula:C23H30N2O5SForma y color:SolidPeso molecular:446.56SKF 91488 dihydrochloride
CAS:<p>histamine N-methyltransferase inhibitor</p>Fórmula:C7H19Cl2N3SPureza:98%Forma y color:SolidPeso molecular:248.22MAT2A inhibitor 3
CAS:<p>MAT2A inhibitor 3 can be used in the cancer research.</p>Fórmula:C16H14ClN3OForma y color:SolidPeso molecular:299.75GDC-4379
CAS:<p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>Fórmula:C21H18ClF2N7O3Forma y color:SolidPeso molecular:489.86INCB054329 Racemate
CAS:<p>INCB054329 Racemate is an inhibitor of BET protein.</p>Fórmula:C19H16N4O3Pureza:98%Forma y color:SolidPeso molecular:348.36JAK3i
CAS:<p>JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.</p>Fórmula:C18H15FN4O3Pureza:98.61% - 99.81%Forma y color:SolidPeso molecular:354.34BAY1238097
CAS:<p>BAY1238097 is a BET inhibitor with anticancer activity and antiproliferative activity for the study of advanced refractory malignancies.</p>Fórmula:C25H33N5O3Pureza:98.1% - 98.79%Forma y color:SolidPeso molecular:451.56HDAC6-IN-10
CAS:<p>HDAC6-IN-10 is a potent HDAC6 inhibitor with 0.73 nM IC50, highly selective, and hinders multiple myeloma cell growth.</p>Fórmula:C21H20N4O4Forma y color:SolidPeso molecular:392.41EML741
CAS:<p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>Fórmula:C31H49N5O2Pureza:98%Forma y color:SolidPeso molecular:523.75IHCH-3064
CAS:<p>IHCH-3064: dual-action cancer immunotherapy, A2AR affinity (Ki 2.2 nM), selective HDAC1 inhibitor (IC50 80.2 nM).</p>Fórmula:C25H21N9O2Forma y color:SolidPeso molecular:479.49HDAC6-IN-6
CAS:<p>HDAC6-IN-6: Potent HDAC6 blocker, BBB-permeable, IC50: 0.025μM; inhibits AChE, Aβ 1-42 aggregation; promotes neurite growth, low neurotoxicity.</p>Fórmula:C20H15N3O2Forma y color:SolidPeso molecular:329.35MI-3
CAS:<p>MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).</p>Fórmula:C18H25N5S2Pureza:98.66% - 99.61%Forma y color:SolidPeso molecular:375.55JAK-IN-18
CAS:<p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>Fórmula:C27H28F2N6O3Forma y color:SolidPeso molecular:522.55MAT2A-IN-5
CAS:<p>MAT2A-IN-5 inhibits MAT2A in tumors, curbing growth in gastric, colon, liver, and pancreatic cancers.</p>Fórmula:C17H12ClF3N2OForma y color:SolidPeso molecular:352.74Setin-1
CAS:<p>Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.</p>Fórmula:C29H21F3N2O2Pureza:98%Forma y color:SolidPeso molecular:486.48GSK 525768A
CAS:<p>GSK 525768A, the inactive enantiomer of GSK525762A, exhibits no activity towards BET.</p>Fórmula:C22H22ClN5O2Forma y color:SolidPeso molecular:423.9OXFBD03
CAS:<p>OXFBD03 is the bromodomain and extra terminal domain bromodomain family member BRD4(1) inhibitor.</p>Fórmula:C20H19NO4Pureza:98%Forma y color:SolidPeso molecular:337.37LY 170198
CAS:<p>LY 170198 is a protein kinase C inhibitor.</p>Fórmula:C22H25N5O5Pureza:98%Forma y color:SolidPeso molecular:439.46SIRT6-IN-1
CAS:<p>SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice.</p>Fórmula:C19H14N4O5SForma y color:SolidPeso molecular:410.4DHPCC-9
CAS:<p>DHPCC-9 is an inhibitor of Pim kinase.</p>Fórmula:C15H10N2OForma y color:SolidPeso molecular:234.25DC_501
CAS:<p>DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.</p>Fórmula:C25H23Cl2N3OPureza:98%Forma y color:SolidPeso molecular:452.38ST7710AA1
CAS:<p>ST7710AA1 inhibits PARP-1, effectively targets in vitro, and overcomes Pgp-associated multidrug resistance.</p>Fórmula:C20H22N4OForma y color:SolidPeso molecular:334.41DCE_254
CAS:<p>DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Fórmula:C21H17N9OSPureza:98%Forma y color:SolidPeso molecular:443.48Langkamide
CAS:<p>Langkamide is a HIF-2 inhibitor with EC₅₀ values of 14.0 uM.</p>Fórmula:C16H17NO5Pureza:98%Forma y color:SolidPeso molecular:303.31NCGC00247743
CAS:<p>NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.</p>Fórmula:C24H29N3O2Pureza:98%Forma y color:SolidPeso molecular:391.51NSC 698600
CAS:<p>NSC 698600 is a potent inhibitor of PCAF(p300/CBP-associated factor) with IC 50 of 6.51 μM that shows good inhibition activity of cancer cell proliferation [1].</p>Fórmula:C14H12N2O2SForma y color:SolidPeso molecular:272.32BF1
CAS:<p>BF1 is an inhibitor of HAT (histone acetyltransferase) active both in vitro and in vivo.</p>Fórmula:C12H12ClN3SForma y color:SolidPeso molecular:265.76Farnesylthiotriazole
CAS:<p>Farnesylthiotriazole is a persistent PKC activator agent.</p>Fórmula:C17H27N3SPureza:98%Forma y color:SolidPeso molecular:305.48Tenovin-D3
CAS:<p>Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner.</p>Fórmula:C22H27Cl3N4O3SPureza:98%Forma y color:SolidPeso molecular:533.9ML399
CAS:<p>ML399 inhibits menin-MLL interaction, targeting MLL leukemia cells with selective, potent action.</p>Fórmula:C27H28FN3O2Pureza:98%Forma y color:SolidPeso molecular:445.53SPC-180002
CAS:<p>SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.</p>Fórmula:C18H23NO4Pureza:98%Forma y color:SolidPeso molecular:317.38
