Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2238 productos de "Cromatina / Epigenética"
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HIF-IN-33
CAS:<p>HIF-IN-33 is an inhibitor of HIF pathway.</p>Fórmula:C21H17F3N4O2Pureza:98%Forma y color:SolidPeso molecular:414.38NR-160
CAS:<p>NR-160 is a selective HDAC6 inhibitor (IC50=0.03μM), weaker on HDAC1-4,8, toxic to 7 cancer lines, boosts bortezomib and anthracycline effects.</p>Fórmula:C25H21F3N6O3Forma y color:SolidPeso molecular:510.47HPCG
CAS:<p>HPCG is an inhibitor of HIF-1α prolyl hydroxylase.</p>Fórmula:C8H8N2O4Forma y color:SolidPeso molecular:196.16BET-BAY 002
CAS:<p>BET-BAY 002 is an effective BET bromodomain inhibitor demonstrating efficacy in vivo and in vitro against multiple myeloma and leukaemia models.</p>Fórmula:C22H18ClN5OForma y color:SolidPeso molecular:403.86Fagaronine chloride
CAS:<p>Fagaronine chloride is a potent inhibitor of Topoisomerases I.</p>Fórmula:C21H20ClNO4Forma y color:SolidPeso molecular:385.84GPI-15427
CAS:<p>GPI-15427: a potent PARP-1 inhibitor, crosses the blood-brain barrier, boosts TMZ's effects on CNS tumors, and sensitizes cancer to radiotherapy.</p>Fórmula:C20H20N4O2Forma y color:SolidPeso molecular:348.4Lobelane Hydrochloride
CAS:<p>Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.</p>Fórmula:C22H30ClNForma y color:SolidPeso molecular:343.93CPI-1612
CAS:<p>CPI-1612: Oral EP300/CBP HAT inhibitor, IC50 8.1 nM, has anticancer properties.</p>Fórmula:C27H26N6OForma y color:SolidPeso molecular:450.53CTPB
CAS:<p>CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments.</p>Fórmula:C31H43ClF3NO2Pureza:99.77%Forma y color:SolidPeso molecular:554.13SirReal-1
CAS:<p>SirReal-1 is an effective and selective inhibitor of Sirt2.</p>Fórmula:C18H18N4OS2Pureza:98%Forma y color:SolidPeso molecular:370.49Prospasmine
CAS:<p>Prospasmine is an anticholinergic.</p>Fórmula:C17H28ClNO2Pureza:98%Forma y color:SolidPeso molecular:313.87JAK3-IN-12
CAS:<p>JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.</p>Fórmula:C19H19N5O4SForma y color:SolidPeso molecular:413.45Hns 32
CAS:<p>Hns 32 possesses antiarrhythmic properties in dog and guinea pig hearts. It also has vasodilator action.</p>Fórmula:C24H29N3Pureza:98%Forma y color:SolidPeso molecular:359.51I-BET151 dihydrochloride
CAS:<p>I-BET 151 dihydrochloride is a BET bromodomain inhibitor that prevents BET from recruiting to chromatin.</p>Fórmula:C23H23Cl2N5O3Pureza:98%Forma y color:SolidPeso molecular:488.37CEP-8983
CAS:<p>CEP-8983 is a PARP inhibitor potentially for the treatment of solid tumours.</p>Fórmula:C18H14N2O3Pureza:98%Forma y color:SolidPeso molecular:306.32Vibsanin A
CAS:<p>Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.</p>Fórmula:C25H38O4Forma y color:SolidPeso molecular:402.57Sirtuin modulator 4
CAS:<p>Sirtuin modulator 4 inhibits SIRT1 (EC50: 51-100 μM), may extend cell life and prevent diseases like diabetes and cancer.</p>Fórmula:C18H10N2O2SForma y color:SolidPeso molecular:318.35CMP-5 hydrochloride
CAS:<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Fórmula:C21H22ClN3Pureza:98%Forma y color:SolidPeso molecular:351.87HDAC6-IN-5
CAS:<p>HDAC6-IN-5 (11b), potent HDAC6 blocker, crosses BBB, IC50: 0.025μM, hinders Aβ1-42/AChE aggregation, boosts neurites, low toxicity.</p>Fórmula:C20H14BrN3O2Forma y color:SolidPeso molecular:408.25iBRD4-BD1
CAS:<p>iBRD4-BD1 inhibits BRD4 bromodomain selectively with 12 nM IC50, useful in inflammation and cancer research.</p>Fórmula:C29H30F3N5OForma y color:SolidPeso molecular:521.58GSK926
CAS:<p>GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.</p>Fórmula:C29H35N7O2Forma y color:SolidPeso molecular:513.63CREBBP-IN-9
CAS:<p>CREBBP-IN-9, a CREBBP inhibitor, acts on the bromodomain of the protein.</p>Fórmula:C16H15N5O2SPureza:98%Forma y color:SolidPeso molecular:341.39AMPK activator 1
CAS:<p>AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).</p>Fórmula:C32H33F3N4O3Pureza:98%Forma y color:SolidPeso molecular:578.62CPI-905
CAS:<p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>Fórmula:C18H20N2O5Forma y color:SolidPeso molecular:344.36ZLD2218
CAS:<p>ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies.</p>Fórmula:C22H18N4OForma y color:SolidPeso molecular:354.4Dimethyl-bisphenol A
CAS:<p>DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.</p>Fórmula:C17H20O2Forma y color:SolidPeso molecular:256.34H8-A5
CAS:<p>H8-A5, a HDAC8 inhibitor, shows antiproliferation activity in MDA-MB-231 cancer cells.</p>Fórmula:C14H9F3N2O2SPureza:98%Forma y color:SolidPeso molecular:326.29PI3K/HDAC-IN-1
CAS:<p>PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).</p>Fórmula:C22H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:428.46TP-238
CAS:<p>"TP-238: Potent CECR2/BPTF dual probe; IC50: 30 nM/350 nM. Inhibits BRD9 (pIC50: 5.9); minimal activity on 338 other kinases."</p>Fórmula:C22H30N6O3SForma y color:SolidPeso molecular:458.58Arazine
CAS:<p>Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.</p>Fórmula:C20H33NO3SPureza:90%Forma y color:SolidPeso molecular:367.55PF-00956980
CAS:<p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>Fórmula:C18H26N6OForma y color:SolidPeso molecular:342.44Binucleine 2
CAS:<p>Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.</p>Fórmula:C13H11ClFN5Forma y color:SolidPeso molecular:291.71CBP/p300-IN-10
CAS:<p>CBP/p300-IN-10, potent EP300/CREBBP inhibitor; IC50: 26 nM/39 nM. Potential for cancer research.</p>Fórmula:C25H24F5N5O3Forma y color:SolidPeso molecular:537.48MS453
CAS:<p>MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.</p>Fórmula:C20H27N5O3Forma y color:SolidPeso molecular:385.46WD2000-012547
CAS:<p>WD2000-012547 is a selective inhibitor of poly(ADP-ribose)-polymerase (PARP-1) (pKi: 8.221).</p>Fórmula:C17H14N2OPureza:98%Forma y color:SolidPeso molecular:262.31PRMT5-IN-10
CAS:<p>PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.</p>Fórmula:C13H17N5O4Forma y color:SolidPeso molecular:307.31Depudecin
CAS:<p>Depudecin, a polyketide from Alternaria brassicicola, has an 11-carbon chain with two epoxides and six stereocenters, inhibits HDAC, and is anti-angiogenic.</p>Fórmula:C11H16O4Forma y color:SolidPeso molecular:212.24UMB-32
CAS:<p>UMB-32: Potent, selective BRD4 inhibitor, Kd 550 nM, IC50 637 nM, also targets TAF1.</p>Fórmula:C21H23N5OForma y color:SolidPeso molecular:361.44NV03
CAS:<p>NV03 is a selective antagonist of the UHRF1-H3K9me3 interaction (Kd=2.4 μM) for cancer research. a ligand for E3 ligases in PROTAC synthesis.</p>Fórmula:C19H27N5O2SPureza:99.88%Forma y color:SolidPeso molecular:389.52M122
CAS:<p>M122 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.</p>Fórmula:C24H25N5OS2Forma y color:SolidPeso molecular:463.62Bromodomain inhibitor-10
CAS:<p>Bromodomain inhibitor-10 (compound 128) suppresses BRD4-1/2 with Kd 15 nM/2.5 μM and curbs IL12p40 production.</p>Fórmula:C20H20N4O3Forma y color:SolidPeso molecular:364.4CTK7A
CAS:<p>CTK7A is a water-soluble inhibitor of p300. CTK7A inhibits tumor growth in xenografted mice.</p>Fórmula:C28H24N2NaO6Pureza:98%Forma y color:SolidPeso molecular:507.498FNDR-20123 free base
CAS:<p>FNDR-20123 is a safe, oral first-in-class anti-malarial HDAC inhibitor with low IC50s against Plasmodium and human HDACs.</p>Fórmula:C21H23N5O2Forma y color:SolidPeso molecular:377.44JNJ-7925476 free base
CAS:<p>JNJ-7925476 is an TRI antidepressant agent.</p>Fórmula:C20H19NPureza:98%Forma y color:SolidPeso molecular:273.37p32 Inhibitor M36
CAS:<p>p32 inhibitor M36 is an inhibitor of p32 mitochondrial protein. It binds directly to p32 and inhibits the p32 association with LyP-1.</p>Fórmula:C23H28N8O2Pureza:98%Forma y color:SolidPeso molecular:448.52TAK-418
CAS:<p>TAK-418 is an orally active LSD1/KDM1A inhibitor with a 2.9 nM IC50, potential for autism therapy.</p>Fórmula:C17H25ClN2O2SPureza:99.69%Forma y color:SolidPeso molecular:356.91Aurora A/PKC-IN-1
CAS:<p>Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.</p>Fórmula:C16H14N6OSe2Forma y color:SolidPeso molecular:464.24J1075
CAS:<p>J1075 is an histone deacetylase 8 (HDAC8) inhibitor.</p>Fórmula:C9H6ClNO2SPureza:98%Forma y color:SolidPeso molecular:227.67S-Aristeromycinylhomocysteine
CAS:<p>S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.</p>Fórmula:C15H22N6O4SForma y color:SolidPeso molecular:382.44(R)-OR-S1
CAS:<p>(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.</p>Fórmula:C26H34BrN3O4Pureza:98%Forma y color:SolidPeso molecular:532.47
