Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2238 productos de "Cromatina / Epigenética"
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MAT2A inhibitor 1
CAS:<p>MAT2A inhibitor 1 is an inhibitor of methionine adenosyltransferase 2A (MATA2) (IC50 < l00 nM).</p>Fórmula:C31H22N6OSForma y color:SolidPeso molecular:526.61ZLD10A
CAS:<p>ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.</p>Fórmula:C37H48N4O4Pureza:98%Forma y color:SolidPeso molecular:612.8WAY-260022
CAS:<p>WAY-260022 is the norepinephrine transporter inhibitor.</p>Fórmula:C21H31F3N2O2Pureza:97.61% - 99.41%Forma y color:SolidPeso molecular:400.48CAY10669
CAS:<p>CAY10669 inhibits PCAF (IC50 = 662 μM), is twice as potent as anacardic acid, and reduces H4 acetylation in HepG2 cells at 30-60 μM.</p>Fórmula:C20H22O4Forma y color:SolidPeso molecular:326.39UNC6212 (Kme2)
<p>UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a K D for CBX5 of 5.7 μM .</p>Fórmula:C39H53N7O11Forma y color:SolidPeso molecular:795.88MAT2A-IN-4
CAS:<p>MAT2A-IN-4 can be used for the cancer research that is an inhibitor of methionine adenosyltransferase 2A (MAT2A)[1].</p>Fórmula:C18H16ClN3OForma y color:SolidPeso molecular:325.79SB-429201
CAS:<p>SB-429201 is an effective, selective inhibitor of HDAC1.</p>Fórmula:C28H24N2O3Pureza:98%Forma y color:SolidPeso molecular:436.5JAK3-IN-9
CAS:<p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>Fórmula:C17H23N5O4SForma y color:SolidPeso molecular:393.46CBHA
CAS:<p>m-Carboxycinnamic bishydroxamide: HDAC inhibitor, ID50 = 10 nM (HDAC1), 70 nM (HDAC3), induces apoptosis and tumor growth suppression.</p>Fórmula:C10H10N2O4Forma y color:SolidPeso molecular:222.2BAY-598 R-isomer
CAS:<p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>Fórmula:C22H20Cl2F2N6O3Forma y color:SolidPeso molecular:525.34SYK/JAK-IN-1
CAS:<p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>Fórmula:C24H26N8O3Forma y color:SolidPeso molecular:474.52LB-205
CAS:<p>LB-205 is a Zn 2+ dependent pan-inhibitor of class I and class II HDACs. It also has a long half-life in vivo.</p>Fórmula:C18H21N3O2SForma y color:SolidPeso molecular:343.44INCB16562
CAS:<p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>Fórmula:C19H11Cl2N5Forma y color:SolidPeso molecular:380.23PARP-2/1-IN-2
CAS:<p>PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.</p>Fórmula:C13H16N4OForma y color:SolidPeso molecular:244.29Guadecitabine
CAS:<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>Fórmula:C18H24N9O10PPureza:98%Forma y color:SolidPeso molecular:557.41NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Fórmula:C10H6N4O4SForma y color:SolidPeso molecular:278.24Bromodomain inhibitor-8
CAS:<p>Bromodomain inhibitor-8 is an inhibitor of BET bromodomain used to treat autoimmune and inflammatory diseases.</p>Fórmula:C26H25ClN2O3Forma y color:SolidPeso molecular:448.94CPI-455 HCl
CAS:<p>CPI-455: specific KDM5A inhibitor, IC50=10±1nM, increases H3K4me3, reduces DTPs in cancer cells.</p>Fórmula:C16H15ClN4OPureza:98%Forma y color:SolidPeso molecular:314.77ZL0454
CAS:<p>ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).</p>Fórmula:C18H22N4O3SPureza:98%Forma y color:SolidPeso molecular:374.46DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Fórmula:C29H39Cl3FN9O3Forma y color:SolidPeso molecular:687.04S2101
CAS:<p>S2101 is a specific LSD1 histone demethylase inhibitor with an IC50 of 0.99 μM and a Ki of 0.61 μM, suitable for research into cancer and viral infections.</p>Fórmula:C16H16ClF2NOPureza:98%Forma y color:SolidPeso molecular:311.75LEM-14-1189
CAS:<p>LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.</p>Fórmula:C35H34N6O5S2Pureza:98.06%Forma y color:SolidPeso molecular:682.81BRD4-BD1-IN-2
CAS:<p>BRD4-BD1-IN-2: Potent, selective BRD4-BD1 inhibitor, IC50=2.51µM; 20x less active on BD2; for cardiovascular/cancer research.</p>Fórmula:C20H15Br3N4O2Pureza:99.39%Forma y color:SolidPeso molecular:583.07Y08175
CAS:<p>Y08175, a CBP Bromodomain inhibitor, IC50: 37 nM (AlphaScreen), 178.15 nM (HTRF). Useful in prostate cancer research.</p>Fórmula:C23H19FN4O5Forma y color:SolidPeso molecular:450.42HDAC-IN-43
CAS:<p>HDAC-IN-43: potent HDAC 1/3/6 inhibitor (IC50: 82 nM HDAC1, 45 nM HDAC3, 24 nM HDAC6); weak PI3K/mTOR (IC50: 3.6μM, 3.7μM); anti-proliferative.</p>Fórmula:C22H28N6O4Forma y color:SolidPeso molecular:440.5SIRT5 inhibitor 2
CAS:<p>SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.</p>Fórmula:C18H12Cl2N2O3SPureza:99.38% - 99.87%Forma y color:SolidPeso molecular:407.27HDAC-IN-28
CAS:<p>HDAC-IN-28 is a novel inhibitor of HDAC that significantly inhibits tumour growth and metastasis.</p>Fórmula:C23H26N4O4SForma y color:SolidPeso molecular:454.54UNC0379 TFA
CAS:<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Fórmula:C25H36F3N5O4Forma y color:SolidPeso molecular:527.589F-amidine
CAS:<p>F-amidine is a bioavailable irreversible PAD4 inactivator.</p>Fórmula:C14H19FN4O2Forma y color:SolidPeso molecular:294.321,2,3,4,5,6-Hexabromocyclohexane
CAS:<p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>Fórmula:C6H6Br6Pureza:98%Forma y color:SolidPeso molecular:557.54Bromodomain inhibitor-9
CAS:<p>Bromodomain inhibitor-9 selectively targets BRD4-1 (Kd 12 nM), used in metabolic, inflammatory, fibrotic, and autoimmune disease studies.</p>Fórmula:C24H28N4O5SForma y color:SolidPeso molecular:484.57JNJ-9350
CAS:<p>JNJ-9350: SMOX inhibitor (IC50 0.01 μM), PAO inhibitor (IC50 0.79 μM), for cancer research.</p>Fórmula:C25H22N6OForma y color:SolidPeso molecular:422.48BPTF-IN-1
CAS:<p>BPTF-IN-1 (AU1), a BPTF bromodomain inhibitor with 2.8 μM affinity, shows higher selectivity over BRD4 and possesses antimalarial properties.</p>Fórmula:C23H23FN6O3Forma y color:SolidPeso molecular:450.47Tankyrase-IN-2
CAS:<p>Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively</p>Fórmula:C17H14F2N2O2Pureza:98%Forma y color:SolidPeso molecular:316.3Furamidine dihydrochloride
CAS:<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Fórmula:C18H18Cl2N4OPureza:98.16%Forma y color:SolidPeso molecular:377.27GNE-272
CAS:<p>GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.</p>Fórmula:C22H25FN6O2Forma y color:SolidPeso molecular:424.47SD-1029
CAS:<p>SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.</p>Fórmula:C25H32Br2Cl2N2O3Forma y color:SolidPeso molecular:639.256(5H)-Phenanthridinone
CAS:<p>6(5H)-Phenanthridinone suppresses PARP1/2, reduces RDM4 cell growth, downregulates pro-inflammatory genes, and alleviates EAE symptoms in rats.</p>Fórmula:C13H9NOForma y color:SolidPeso molecular:195.22NCC-149
CAS:<p>NCC-149 is a HDAC8 inhibitor.</p>Fórmula:C16H14N4O2SForma y color:SolidPeso molecular:326.37MS-1020
CAS:<p>MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.</p>Fórmula:C21H18N2O3Pureza:98%Forma y color:SolidPeso molecular:346.38AC-93253 iodide
CAS:<p>AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4.</p>Fórmula:C23H25IN2SPureza:98%Forma y color:SolidPeso molecular:488.43Jaspamycin
CAS:<p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>Fórmula:C12H12N4O5Forma y color:SolidPeso molecular:292.25Ac-Lys-AMC
CAS:<p>Ac-Lys-AMC (Hexanamide) is a fluorescent substrate for histone deacetylase HDACs.</p>Fórmula:C18H23N3O4Pureza:98%Forma y color:SolidPeso molecular:345.39(R)-UT-155
CAS:<p>(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.</p>Fórmula:C20H15F4N3O2Forma y color:SolidPeso molecular:405.35ZYJ-34v
CAS:<p>ZYJ-34v is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.</p>Fórmula:C27H35N3O6Pureza:98%Forma y color:SolidPeso molecular:497.58KD 5170
CAS:<p>KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].</p>Fórmula:C20H25N3O5S2Forma y color:SolidPeso molecular:451.56ARTD10/PARP10-IN-1
CAS:<p>ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.</p>Fórmula:C12H12N2O4Pureza:99.14%Forma y color:SolidPeso molecular:248.23CPI-4203
CAS:<p>CPI-4203 is a selective inhibitor of KDM5 demethylases.</p>Fórmula:C16H14N4OForma y color:SolidPeso molecular:278.31Acefylline piperazine
CAS:<p>Acefylline piperazine, a less toxic theophylline derivative, treats asthma and bronchitis by bronchodilation, stimulating respiration and CNS.</p>Fórmula:C9H10N4O4·xC4H10N2Forma y color:SolidPeso molecular:562.54KDM2B-IN-3
CAS:<p>KDM2B-IN-3, from patent WO2016112284A1 as compound 183c, potently inhibits histone demethylase KDM2B, with cancer research potential.</p>Fórmula:C25H30N2O2Forma y color:SolidPeso molecular:390.52
