Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2242 productos de "Cromatina / Epigenética"
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F-amidine
CAS:<p>F-amidine is a bioavailable irreversible PAD4 inactivator.</p>Fórmula:C14H19FN4O2Forma y color:SolidPeso molecular:294.32ARTD10/PARP10-IN-1
CAS:<p>ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.</p>Fórmula:C12H12N2O4Pureza:99.14%Forma y color:SolidPeso molecular:248.23CPI-4203
CAS:<p>CPI-4203 is a selective inhibitor of KDM5 demethylases.</p>Fórmula:C16H14N4OForma y color:SolidPeso molecular:278.31KD 5170
CAS:<p>KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].</p>Fórmula:C20H25N3O5S2Forma y color:SolidPeso molecular:451.56Acefylline piperazine
CAS:<p>Acefylline piperazine, a less toxic theophylline derivative, treats asthma and bronchitis by bronchodilation, stimulating respiration and CNS.</p>Fórmula:C9H10N4O4·xC4H10N2Forma y color:SolidPeso molecular:562.54KDM2B-IN-3
CAS:<p>KDM2B-IN-3, from patent WO2016112284A1 as compound 183c, potently inhibits histone demethylase KDM2B, with cancer research potential.</p>Fórmula:C25H30N2O2Forma y color:SolidPeso molecular:390.521,2-Didecanoylglycerol
CAS:<p>1,2-Didecanoylglycerol has functions as bioregulator of protein kinase C in human platelets.</p>Fórmula:C23H44O5Forma y color:SolidPeso molecular:400.59TUL01101
CAS:<p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>Fórmula:C22H25F2N5O2Forma y color:SolidPeso molecular:429.46Galegine hydrochloride
CAS:<p>Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.</p>Fórmula:C6H14ClN3Forma y color:SolidPeso molecular:163.65HDAC-IN-28
CAS:<p>HDAC-IN-28 is a novel inhibitor of HDAC that significantly inhibits tumour growth and metastasis.</p>Fórmula:C23H26N4O4SForma y color:SolidPeso molecular:454.54SIRT2-IN-11
CAS:<p>SIRT2-IN-11 (AEM1), a SIRT2 inhibitor (IC50 18.5μM), induces apoptosis and affects p53, used in cancer research.</p>Fórmula:C21H22N2OForma y color:SolidPeso molecular:318.41LSD1-IN-13
CAS:<p>LSD1-IN-13, an oral LSD1 blocker (IC50: 24.43 nM), boosts CD86 (EC50: 470 nM), and triggers AML cell line differentiation.</p>Fórmula:C23H29N3O2SForma y color:SolidPeso molecular:411.56GS-626510
CAS:<p>GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).</p>Fórmula:C25H22N4OForma y color:SolidPeso molecular:394.47AMPK activator
CAS:<p>AMPK activator</p>Fórmula:C22H21FO4Pureza:98%Forma y color:SolidPeso molecular:368.4LW479
CAS:<p>LW479 is a novel inhibitor of HDAC and is a promising candidate for the prevention of breast cancer.</p>Fórmula:C21H23BrN2O4SForma y color:SolidPeso molecular:479.39BI-9321
CAS:<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Fórmula:C22H21FN4Pureza:98%Forma y color:SolidPeso molecular:360.43SHP2/HDAC-IN-1
CAS:<p>SHP2/HDAC-IN-1: dual SHP2/HDAC inhibitor, IC50: 20.4 nM/25.3 nM, boosts antitumor immunity, aids cancer immunotherapy research.</p>Fórmula:C34H35Cl2N7O3Forma y color:SolidPeso molecular:660.59KDM5A-IN-1
CAS:<p>KDM5A-IN-1 is a pan-histidine lysine demethylase 5 KDM5 inhibitor that inhibits KDM5A, KDM5B, and KDM5C.Can be used in the study of cancer.</p>Fórmula:C15H22N4O2Pureza:>99.99%Forma y color:SolidPeso molecular:290.36BiBET
CAS:<p>BiBET is a potent, selective, bivalent inhibitor of BET bromodomains.</p>Fórmula:C26H30N10O3Forma y color:SolidPeso molecular:530.58DC_517
CAS:<p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>Fórmula:C33H35N3O2Forma y color:SolidPeso molecular:505.656-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Fórmula:C9H14N4O5Pureza:98%Forma y color:SolidPeso molecular:258.23L 888607 Racemate
CAS:<p>L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.</p>Fórmula:C19H15ClFNO2SForma y color:SolidPeso molecular:375.84Tyk2-IN-7
CAS:<p>Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).</p>Fórmula:C18H15D3N6O3SPureza:98%Forma y color:SolidPeso molecular:401.46TK4g
CAS:<p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.</p>Fórmula:C19H19N3O4SForma y color:SolidPeso molecular:385.44Pulrodemstat Methylbenzenesulfonate
CAS:<p>LSD1-IN-7 Methylbenzenesulfonate is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.</p>Fórmula:C31H31F2N5O5SPureza:98%Forma y color:SolidPeso molecular:623.67HIF-1/2α-IN-2
CAS:<p>HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.</p>Fórmula:C16H11FN4O2SForma y color:SolidPeso molecular:342.35NSD3-IN-1
CAS:<p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>Fórmula:C13H13N5OSForma y color:SolidPeso molecular:287.34YM-53601 free base
CAS:<p>YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.</p>Fórmula:C21H21FN2OPureza:98%Forma y color:SolidPeso molecular:336.4EP009
CAS:<p>EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.</p>Fórmula:C14H24O2Forma y color:SolidPeso molecular:224.34MDK8228
CAS:<p>MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.</p>Fórmula:C31H41N5O3Forma y color:SolidPeso molecular:531.69HPB
CAS:<p>HPB is a selective HDAC6 deacetylase inhibitor</p>Fórmula:C18H20N2O4Forma y color:SolidPeso molecular:328.36RM65
CAS:<p>RM65 is an arginine methyltransferase inhibitor.</p>Fórmula:C34H32N2O4S2Pureza:98%Forma y color:SolidPeso molecular:596.76ZIKV-IN-3
CAS:<p>ZIKV-IN-3, an andrographolide derivative, inhibits ZIKV NS5 MTase (IC50: 18.34 μM) and replication. Used for Zika virus research.</p>Fórmula:C39H41NO4Forma y color:SolidPeso molecular:587.75Dot1L-IN-7
CAS:<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Fórmula:C23H27N9O2Forma y color:SolidPeso molecular:461.52NVS-BET-1
CAS:<p>NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity.</p>Fórmula:C22H21ClN4O2Forma y color:SolidPeso molecular:408.88Ilorasertib hydrochloride
CAS:<p>Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:</p>Fórmula:C25H22ClFN6O2SPureza:98.45%Forma y color:SolidPeso molecular:525Butyzamide
CAS:<p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>Fórmula:C29H32Cl2N2O5SPureza:99.51% - 99.83%Forma y color:SoildPeso molecular:591.55TNG908
CAS:<p>TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.</p>Fórmula:C21H23N5O2SPureza:98.08% - 98.24%Forma y color:SolidPeso molecular:409.51GRK6-IN-1
CAS:<p>GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.</p>Fórmula:C22H23ClN6O2Pureza:99.37%Forma y color:SolidPeso molecular:438.91Flosequinan
CAS:<p>Flosequinan is an arteriovenous vasodilator, which can effectively treat acute heart failure.</p>Fórmula:C11H10FNO2SPureza:99.95%Forma y color:SolidPeso molecular:239.27Crebinostat
CAS:<p>Crebinostat: potent HDAC inhibitor, boosts synapsin-1 in neurons, enhances memory and gene Egr1 expression in mice.</p>Fórmula:C20H23N3O3Pureza:94.96%Forma y color:SolidPeso molecular:353.41OXF BD 02
CAS:<p>OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.</p>Fórmula:C18H17NO3Pureza:98.25%Forma y color:SolidPeso molecular:295.33Raxofelast
CAS:<p>Raxofelast (IRFI-016), a vitamin-like, hydrophilic antioxidant, mitigates ischemia-reperfusion in testis and may treat diabetic issues and atherosclerosis.</p>Fórmula:C15H18O5Pureza:99.74% - 99.97%Forma y color:SolidPeso molecular:278.3MAT2A-IN-9
CAS:<p>MAT2A-IN-9, a 2-oxoquinazoline, inhibits MAT2A with antitumor effects on lymphomas and solid cancers.</p>Fórmula:C14H8ClF3N4OPureza:99.17%Forma y color:SolidPeso molecular:340.69Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Fórmula:C16H13Cl2N3OPureza:99.22%Forma y color:SolidPeso molecular:334.2LSD1-IN-20
CAS:<p>LSD1-IN-20: Dual LSD1/G9a inhibitor, Ki 0.44/0.68 μM; hampers THP-1, MDA-MB-231 cell growth with IC50 0.51/1.60 μM at 72h.</p>Fórmula:C27H38N6O2Pureza:98.44% - 99.57%Forma y color:SolidPeso molecular:478.63BAY-299
CAS:<p>BAY-299 inhibits BRPF2, TAF1, and TAF1L with IC50s of 67, 8, and 106 nM.</p>Fórmula:C25H23N3O4Pureza:99.53%Forma y color:SolidPeso molecular:429.47R 59-022 hydrochloride
CAS:<p>R 59-022 hydrochloride is a 5-HT antagonist, PKC activator, DGK inhibitor (IC50: 2.8 µM), and modulates lipid production in platelets and neutrophils.</p>Fórmula:C27H27ClFN3OSPureza:97.7%Forma y color:SolidPeso molecular:496.04ZEN-2759
CAS:<p>ZEN-2759 is a potent BET small molecule inhibitor of BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).</p>Fórmula:C17H16N2O2Pureza:99.36%Forma y color:SolidPeso molecular:280.32CEP-9722
CAS:<p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>Fórmula:C24H26N4O3Pureza:98.38% - 98.56%Forma y color:SolidPeso molecular:418.49
