Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2242 productos de "Cromatina / Epigenética"
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JAK2-IN-4
CAS:<p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>Fórmula:C23H27N5O4SPureza:98%Forma y color:SolidPeso molecular:469.56FHT-2344
CAS:<p>FHT-2344, a SMARCA4/SMARCA2 ATPase inhibitor, exhibits anticancer activity with half-maximal inhibitory concentrations (IC 50 ) of 0.026 μM for SMARCA4 and 0.013 μM for SMARCA2, respectively [1].</p>Fórmula:C23H24N6O5S2Forma y color:SolidPeso molecular:528.6PI3K/HDAC-IN-2
CAS:<p>PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.</p>Fórmula:C23H23N7O4Forma y color:SolidPeso molecular:461.47HDAC6-IN-34
CAS:<p>HDAC6-IN-34 (compound 21), an orally active, selective HDAC6 inhibitor, exhibits an IC50 of 18 nM. It enhances tubulin acetylation levels without impacting histone acetylation in cutaneous T-cell lymphoma cells and suppresses TNF-α secretion in LPS-stimulated macrophage cells. Furthermore, HDAC6-IN-34 demonstrates outstanding anti-arthritic efficacy in rats [1].</p>Fórmula:C18H18F3N3O3Forma y color:SolidPeso molecular:381.35DNMT-IN-3
CAS:<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Fórmula:C37H39N7OForma y color:SolidPeso molecular:597.75F-Amidine TFA
CAS:<p>F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.</p>Fórmula:C14H19FN4O2CF3COOHForma y color:SolidPeso molecular:408.4Itacnosertib (hydrocholide)
CAS:<p>Itacnosertib hydrochloride acts as an inhibitor targeting JAK2, ACVR1 (ALK2), and ALK5 [1].</p>Fórmula:C26H29ClN8OForma y color:SolidPeso molecular:505.01CW 008
CAS:<p>CW 008 is an agonist of the cAMP/PKA/CREB pathway, promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells (MSCs).a PKA activator.</p>Fórmula:C21H14F2N6O2Pureza:97.39%Forma y color:SolidPeso molecular:420.37JAK-IN-26
CAS:<p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>Fórmula:C22H24N6O3Pureza:98%Forma y color:SolidPeso molecular:420.46JBI-589
CAS:<p>JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.</p>Fórmula:C29H28FN5OForma y color:SolidPeso molecular:481.56MS023 trihydrochloride
CAS:<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Fórmula:C17H28Cl3N3OPureza:99.81%Forma y color:SolidPeso molecular:396.78JAK-IN-1
CAS:<p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>Fórmula:C20H24N6O2Pureza:98%Forma y color:SolidPeso molecular:380.44CAY10398
CAS:<p>CAY10398 is a compound that serves as an isoform-selective inhibitor of histone deacetylase (HDAC1).</p>Fórmula:C15H23N3O3Forma y color:SolidPeso molecular:293.367KDM5-IN-1
CAS:<p>KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.</p>Fórmula:C17H20N6OPureza:99.50%Forma y color:SolidPeso molecular:324.38dBRD4-BD1
CAS:<p>dBRD4-BD1 selectively inhibits and degrades BRD4 (DC50=280nM), upregulates BRD2/3, and aids in creating BRD4-specific probes.</p>Fórmula:C50H53F3N8O9Forma y color:SolidPeso molecular:967Tubulin/JAK2-IN-1
CAS:<p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>Fórmula:C22H20N6O3Forma y color:SolidPeso molecular:416.43HIF-2α-IN-13
CAS:<p>HIF-2α-IN-13 (18) acts as a HIF-2α inhibitor and exhibits an IC 50 value of 2.7 μM.</p>Fórmula:C15H14ClF4NO2Forma y color:SolidPeso molecular:351.72KF21213
CAS:<p>KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.</p>Fórmula:C19H22N4O3Pureza:98%Forma y color:SolidPeso molecular:354.4Lepzacitinib
CAS:<p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>Fórmula:C18H21N5O3Pureza:99.85%Forma y color:SolidPeso molecular:355.39KAT modulator-1
CAS:<p>KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].</p>Fórmula:C20H36O2Pureza:98%Forma y color:SolidPeso molecular:308.5BY27
CAS:<p>BY27 is a BET BD2 inhibitor with anticancer activity that inhibits BRD2, BRD3 and BRD4 and suppresses tumor growth.</p>Fórmula:C22H21ClN6Pureza:99.4% - 99.68%Forma y color:SolidPeso molecular:404.89Lin281632
CAS:<p>Lin281632 is an inhibitor of RNA binding protein Lin28 and bromodomain. Lin281632 promotes mESC differentiation.</p>Fórmula:C15H15N5OPureza:99.84%Forma y color:SolidPeso molecular:281.31BRCA1-IN-2
CAS:<p>BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.</p>Fórmula:C26H33N4O7PPureza:98.04%Forma y color:SolidPeso molecular:544.54ZL0420
CAS:<p>ZL0420: Potent, selective BRD4 inhibitor, IC50 27 nM BD1 & 32 nM BD2.</p>Fórmula:C16H16N4O2Pureza:99.38%Forma y color:SolidPeso molecular:296.32CBP/p300-IN-5
CAS:P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).Fórmula:C29H27F5N6O4Pureza:98%Forma y color:SolidPeso molecular:618.55ZINC08792355
CAS:<p>ZINC08792355 is a novel inhibitor of SIRT1.</p>Fórmula:C31H24N4O3Forma y color:SolidPeso molecular:500.55CLB-016
CAS:<p>CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.</p>Fórmula:C17H20N6O3Pureza:98%Forma y color:SolidPeso molecular:356.38RTS-V5
CAS:<p>RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).</p>Fórmula:C27H35N5O6Pureza:98%Forma y color:SolidPeso molecular:525.6A1B11
CAS:<p>A1B11 is a selective SIRT2 inhibitor.</p>Fórmula:C22H25N5OForma y color:SolidPeso molecular:375.47Luteolin 7-sulfate
CAS:<p>Luteolin 7-sulfate from Phyllospadix iwatensis inhibits melanin production by disrupting CREB/MITF signaling.</p>Fórmula:C15H10O9SPureza:98%Forma y color:SolidPeso molecular:366.3NSC756093
CAS:<p>NSC756093 potentially inhibits GBP1:PIM1 interaction. NSC756093 can be used in ovarian cancer studies.</p>Fórmula:C20H19NO4Pureza:99.92%Forma y color:SolidPeso molecular:337.37PARPYnD
CAS:<p>PARPYnD: Photoaffinity PARP probe; inhibits PARP2, PARP1, PARP6 (IC50: 6, 38, 230 nM); tags PARP1/2 with N3 fluorescent probe.</p>Fórmula:C34H31N9O3Forma y color:SolidPeso molecular:613.67I-BET762 carboxylic acid
CAS:<p>I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).</p>Fórmula:C20H17ClN4O3Pureza:98%Forma y color:SolidPeso molecular:396.83KP-544
CAS:<p>KP-544 is an agent of neurotrophin potentiator.</p>Fórmula:C18H19ClN4OPureza:98%Forma y color:SolidPeso molecular:342.82L-Moses
CAS:L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).Fórmula:C21H24N6Pureza:98%Forma y color:SolidPeso molecular:360.46ZINC08792229
CAS:<p>ZINC08792229 is a novel inhibitor of SIRT1.</p>Fórmula:C30H22N4O3Pureza:98%Forma y color:SolidPeso molecular:486.52HA-1004 dihydrochloride
CAS:<p>HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein</p>Fórmula:C12H16ClN5O2SPureza:98%Forma y color:White Crystalline SolidPeso molecular:329.81MS67
CAS:<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Fórmula:C52H59F4N9O7SForma y color:SolidPeso molecular:1030.14CBP/p300-IN-19 hydrochloride
CAS:<p>CBP/p300-IN-19 HCl is a p300/CBP HAT inhibitor (IC50: p300 1.4 μM, CBP 2.2 μM) with antitumor properties.</p>Fórmula:C30H28ClN3O3Forma y color:SolidPeso molecular:514.02KT-531
CAS:<p>KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.</p>Fórmula:C17H14F4N2O4SForma y color:SolidPeso molecular:418.36Bisegliptin
CAS:<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Fórmula:C18H26FN3O3Pureza:98%Forma y color:SolidPeso molecular:351.42KDM2A/7A-IN-1
CAS:<p>KDM2A/7A-IN-1 is a KDM2A/7A inhibitor with potential anti-tumour activity for the study of duodenal adenomas and ossifying fibromucoid tumours.</p>Fórmula:C33H38N4OPureza:99.59%Forma y color:SolidPeso molecular:506.68GNE-955
CAS:<p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>Fórmula:C22H24N8OPureza:98%Forma y color:SolidPeso molecular:416.48UNC8153 TFA
CAS:<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Fórmula:C35H38F3N5O7Pureza:96.44%Forma y color:SolidPeso molecular:697.7Nezulcitinib
CAS:<p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>Fórmula:C30H37N7O2Forma y color:SolidPeso molecular:527.66SIRT5 inhibitor 7
CAS:<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Fórmula:C28H32ClN7O3SPureza:99.77%Forma y color:SolidPeso molecular:582.12GNE-207
CAS:<p>GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM).</p>Fórmula:C29H30N6O3Pureza:98%Forma y color:SolidPeso molecular:510.59FT895
CAS:<p>FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.</p>Fórmula:C16H15F3N4O2Pureza:98.95% - >99.99%Forma y color:SolidPeso molecular:352.31NHWD-870
CAS:<p>NHWD-870 selectively inhibits BET bromodomains BRD2-4, BRDT; potent anti-cancer effect by inducing apoptosis, halting cell growth.</p>Fórmula:C29H29N7OPureza:98%Forma y color:SolidPeso molecular:491.59T-448 free base
CAS:<p>T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).</p>Fórmula:C17H20N4OSPureza:98%Forma y color:SolidPeso molecular:328.43
