Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2238 productos de "Cromatina / Epigenética"
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AGI-25696
CAS:<p>AGI-25696 inhibits MATA2, blocking MTAP-deleted tumor growth, potential for cancer research.</p>Fórmula:C27H18N4OPureza:98.40% - 99.74%Forma y color:SolidPeso molecular:414.46JAK-IN-31
CAS:<p>JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,</p>Fórmula:C21H19N7O2S2Pureza:98%Forma y color:SolidPeso molecular:465.55ABBV-712
CAS:<p>ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases</p>Fórmula:C24H28N4O5Pureza:98%Forma y color:SolidPeso molecular:452.5GSK737
CAS:<p>GSK737 is a dual inhibitor of BRD4 BD1 and BD2, exhibiting pIC50 values of 5.3 and 7.3, respectively.</p>Fórmula:C20H21N5O2Pureza:98%Forma y color:SolidPeso molecular:363.41AAPK-25
CAS:<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Fórmula:C21H13Cl2N3O2SPureza:97.05%Forma y color:SolidPeso molecular:442.32Demethyleneberberine chloride
CAS:<p>Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-</p>Fórmula:C19H18ClNO4Pureza:98%Forma y color:SolidPeso molecular:359.8Amelparib
CAS:<p>Amelparib (JPI-289) is an inhibitor of the poly-ADP-ribose polymerase.</p>Fórmula:C19H25N3O3Pureza:98%Forma y color:SolidPeso molecular:343.42BATCP
CAS:<p>BATCP is an inhibitor of histone deacetylases (HDAC) [1].</p>Fórmula:C23H28F3N3O6Forma y color:SolidPeso molecular:499.487AKB-6899
CAS:<p>AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated</p>Fórmula:C14H11FN2O4Pureza:97.87%Forma y color:SolidPeso molecular:290.25Sirt2-IN-5
CAS:<p>Sirt2-IN-5 is a potent inhibitor of SIRT2.</p>Fórmula:C26H27Cl2N5O3Forma y color:SolidPeso molecular:528.43MARK-IN-1
CAS:<p>MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).</p>Fórmula:C22H23F2N7OSPureza:98%Forma y color:SolidPeso molecular:471.53XDM-CBP
CAS:<p>XDM-CBP is an effective and selective CBP/p300 bromodomain inhibitor.</p>Fórmula:C21H22N2O4Pureza:98%Forma y color:SolidPeso molecular:366.41DY-46-2
CAS:<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Fórmula:C19H22N6O5SPureza:99.12% - 99.12%Forma y color:SolidPeso molecular:446.48Prolyl Hydroxylase inhibitor 1
CAS:<p>Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).</p>Fórmula:C19H18ClN5O4Pureza:98%Forma y color:SolidPeso molecular:415.83K-756
CAS:<p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>Fórmula:C24H27N5O3Pureza:99.81%Forma y color:SolidPeso molecular:433.5QL-1200186
CAS:<p>QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following</p>Fórmula:C26H27N7O3Pureza:98%Forma y color:SolidPeso molecular:485.54JAK kinase-IN-1
CAS:<p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>Fórmula:C17H19F2N7OSPureza:98%Forma y color:SolidPeso molecular:407.44JAK-IN-25
CAS:<p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>Fórmula:C19H17N5O4Pureza:98%Forma y color:SolidPeso molecular:379.37JAK-IN-17
<p>"JAK-IN-17: Potent JAK inhibitor for studying ocular, skin, and respiratory diseases."</p>Fórmula:C33H38F2N6O8Forma y color:SolidPeso molecular:684.69BChE/HDAC6-IN-1
CAS:<p>BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6.</p>Fórmula:C34H43N5O5Pureza:98%Forma y color:SolidPeso molecular:601.74HDAC/HSP90-IN-3
CAS:<p>HDAC/HSP90-IN-3, a dual inhibitor targeting fungal Hsp90 (IC50: 0.83 μM) & HDAC (IC50: 0.91 μM), counters azole-resistant C. albicans.</p>Fórmula:C26H33N5O6Forma y color:SolidPeso molecular:511.57RK-701
CAS:<p>RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.</p>Fórmula:C26H30N4O3Forma y color:SolidPeso molecular:446.54Aurora kinase inhibitor-8
CAS:<p>Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.</p>Fórmula:C30H29N7O3Forma y color:SolidPeso molecular:535.6EPZ-030456
CAS:<p>EPZ-030456 is an effective and selective inhibitor of the SMYD3.</p>Fórmula:C28H34ClN5O4SForma y color:SolidPeso molecular:572.12PF-06679142
CAS:<p>PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.</p>Fórmula:C20H17F2NO3Pureza:98%Forma y color:SolidPeso molecular:357.35GSK-A
CAS:<p>GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.</p>Fórmula:C21H25N5O2Forma y color:SolidPeso molecular:379.46CC-90005
CAS:<p>CC-90005 is a potent, selective oral PKC-θ inhibitor with an IC50 of 8 nM, preferential over PKC-δ, and inhibits T cell activation.</p>Fórmula:C21H27F2N7O2Forma y color:SolidPeso molecular:447.48KDM2B-IN-1
CAS:<p>KDM2B-IN-1: Potent, specific KDM2B histone demethylase inhibitor for hyperproliferative disease research.</p>Fórmula:C21H30N4O2SForma y color:SolidPeso molecular:402.56PRMT5-IN-16
CAS:<p>PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.</p>Fórmula:C25H34N8O2Forma y color:SolidPeso molecular:478.59OM-1700
CAS:<p>OM-1700 inhibits tankyrase 1 (IC50=127 nM) and 2 (IC50=14 nM); hinders colon cancer cell growth, COLO 320DM (GI50=650 nM).</p>Fórmula:C25H23FN6O2Forma y color:SolidPeso molecular:458.49FD1024
CAS:<p>FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.</p>Fórmula:C21H20F2N4O2SPureza:98%Forma y color:SolidPeso molecular:430.47Tyk2-IN-9
CAS:<p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>Fórmula:C20H17N9Pureza:98%Forma y color:SolidPeso molecular:383.41CARM1-IN-3
CAS:<p>CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for</p>Fórmula:C24H32N4O2Pureza:98%Forma y color:SolidPeso molecular:408.54NMS-P515
CAS:<p>NMS-P515 is an effective, orally active, and stereospecific PARP-1 inhibitor (Kd: 16 nM and an IC50: 27 nM (in Hela cells)). It has anti-tumor activity.</p>Fórmula:C21H29N3O2Pureza:98%Forma y color:SolidPeso molecular:355.47RK-0133114
<p>RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.</p>Fórmula:C26H30N4O3Forma y color:SolidPeso molecular:446.54JQKD82 dihydrochloride
CAS:<p>JQKD82 (JADA82) dihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels, making it effective for multiple myeloma research [1].</p>Fórmula:C27H42Cl2N4O5Forma y color:SolidPeso molecular:573.55QQN-00358
CAS:<p>QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor.</p>Fórmula:C26H24F3N3O4Forma y color:SolidPeso molecular:499.48MS31
CAS:<p>MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1).</p>Fórmula:C20H27N3O2Pureza:98%Forma y color:SolidPeso molecular:341.45Upadacitinib tartrate
CAS:<p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>Fórmula:C21H33F3N6O11Pureza:98%Forma y color:SolidPeso molecular:602.521CBP/p300-IN-15
CAS:<p>CBP/p300-IN-15 inhibits p300 (IC50: 2.5 nM) & CBP (28 nM), affects OVCAR-3 (EC50: 0.865 μM) & A2780 cells (2.71 μM) for ovarian cancer research.</p>Fórmula:C26H28N4O5Forma y color:SolidPeso molecular:476.52PARP1-IN-7
CAS:<p>PARP1-IN-7 functions as an anticancer agent by inhibiting poly(ADP-ribose) polymerase-1 (PARP1).</p>Fórmula:C24H23N5OForma y color:SolidPeso molecular:397.47Ro 32-0432 hydrochloride
CAS:<p>Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.</p>Fórmula:C28H28N4O2Pureza:98%Forma y color:SolidPeso molecular:452.55PIM-IN-2
CAS:<p>PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .</p>Fórmula:C19H22N4O2Pureza:98%Forma y color:SolidPeso molecular:338.4BET-IN-9
CAS:<p>BET-IN-9 is a BET inhibitor[1].</p>Fórmula:C22H24N4O3Forma y color:SolidPeso molecular:392.45PIN1 inhibitor 2
CAS:<p>PIN1 inhibitor 2, compound 12, impedes PIN1, shows promise in breast cancer study, and has IC50 of 9.55 μM in MCF7 cells.</p>Fórmula:C16H21N3S2Forma y color:SolidPeso molecular:319.49CBB1007
CAS:<p>CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).</p>Fórmula:C27H34N8O4Pureza:98%Forma y color:SolidPeso molecular:534.61AMPK activator 7
CAS:<p>AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.</p>Fórmula:C23H22F3N3O5Forma y color:SolidPeso molecular:477.43PARP7-probe-1
CAS:<p>PARP7-probe-1: biotinylated, chemiluminescent PARP7 active site probe for research use.</p>Fórmula:C36H49F3N8O5SForma y color:SolidPeso molecular:762.89PRT543
CAS:<p>PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.</p>Fórmula:C17H17ClN4O4Forma y color:SolidPeso molecular:376.79SP-2-225
CAS:<p>SP-2-225, a selective inhibitor of HDAC6, augments the production of cancer-associated antigens and enhances macrophage antigen cross-presentation to T cells,</p>Fórmula:C28H34N2O3Pureza:98%Forma y color:SolidPeso molecular:446.58
