Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2441 productos de "Cromatina / Epigenética"
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(1-Nitroethene-1,2-diyl)dibenzene
CAS:(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Fórmula:C14H11NO2Forma y color:SolidPeso molecular:225.24HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Fórmula:C18H19N3O3Forma y color:SolidPeso molecular:325.36CM-414
CAS:CM-414: HDAC/PDE5 inhibitor, targeting Alzheimer’s, IC50s: PDE5 (60 nM), HDAC1/2/3/6. Reduces Aβ, pTau in mice, boosts cognition.Fórmula:C23H29N5O4Pureza:98%Forma y color:SolidPeso molecular:439.51HIF-1/2α-IN-1
HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.Fórmula:C17H16N6O4Forma y color:SolidPeso molecular:368.35RL5a
CAS:RL5a (compound C23) is a novel inhibitor of SETD8.Fórmula:C17H19N3OForma y color:SolidPeso molecular:281.35Itareparib
CAS:Itareparib is a PARP inhibitor with demonstrated antitumor activity.Fórmula:C20H26FN3O2Forma y color:SolidPeso molecular:359.438JAK3-IN-7
CAS:JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction afterFórmula:C17H20N6OPureza:98.81%Forma y color:SolidPeso molecular:324.38SGC-BRDVIII-NC
CAS:SGC-BRDVIII-NC (Compound 35) serves as a negative control for the SMARCA2/4 and PB1 bromodomain (BRD) inhibitors. The binding ability of the protein-ligand is completely eliminated in SGC-BRDVIII-NC through the methylation of the phenolic hydroxyl group. This compound is applicable for research in adipogenesis.Fórmula:C20H27N5O3Forma y color:SolidPeso molecular:385.46rel-A-395 hydrochloride
CAS:rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Fórmula:C26H36ClFN4O2SForma y color:SolidPeso molecular:523.11Enzomenib
CAS:<p>Enzomenib (DSP5336), a menin protein inhibitor encoded by the multiple endocrine neoplasia (MEN) gene, blocks the interaction between menin protein and mixed lineage leukemia (MLL) fusion proteins. This compound is utilized in researching hematological malignancies.</p>Fórmula:C33H43FN6O3Forma y color:SolidPeso molecular:590.73TD034
CAS:TD034 is a selective, reversible, non-covalent inhibitor of HDAC11, with an IC50 of 5.1 nM and a Ki of 1.5 nM. It does not inhibit other HDACs or sirtuins. TD034 inhibits the desuccinylation of SHMT2 (a substrate of HDAC11) and lowers YAP1 levels by inhibiting HDAC11. TD034 is applicable for lung cancer research.Fórmula:C45H64N4O6Forma y color:SolidPeso molecular:757.01TYK2 ligand 2
CAS:TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.Fórmula:C24H20FN7O4Forma y color:SolidPeso molecular:489.458MI-1481
CAS:MI-1481: potent MML1 inhibitor, IC50 3.6 nM; disrupts menin-MLL1, active in MLL leukemia.Fórmula:C29H30F3N7O2SPureza:98%Forma y color:SolidPeso molecular:597.65EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Fórmula:C19H19FN8OForma y color:SolidPeso molecular:394.41MMSET-IN-1
CAS:MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .Fórmula:C18H29N7O5Pureza:98%Forma y color:SolidPeso molecular:423.47SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.Fórmula:C20H20N6O5SForma y color:SolidPeso molecular:456.48Equisetin
CAS:Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.Fórmula:C22H31NO4Pureza:98%Forma y color:SolidPeso molecular:373.49SGC6870N
CAS:<p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>Fórmula:C23H21BrN2O2SPeso molecular:469.39AZ-3
CAS:AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).Fórmula:C20H28FN7Pureza:98%Forma y color:SolidPeso molecular:385.48Ad-JQ1
CAS:Ad-JQ1 (Compound 16) is a Target Protein Ligand-Linker Conjugate incorporating a BRD4 ligand and a PROTAC linker capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACβ-NF-JQ1.Fórmula:C37H47ClN6O4SForma y color:SolidPeso molecular:707.33
