Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(51 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
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Se han encontrado 958 productos de "Daño al ADN / Reparación del ADN"
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Epigenetic factor-IN-1
CAS:<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Fórmula:C32H34FN5O6S2Pureza:98%Forma y color:SolidPeso molecular:667.77PR-104A
CAS:<p>PR-104A is a hypoxia-targeted anticancer agent.</p>Fórmula:C14H19BrN4O9SForma y color:SolidPeso molecular:499.29ATM-IN-1
CAS:<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Fórmula:C30H36N6O3Forma y color:SolidPeso molecular:528.65Pradofloxacin
CAS:<p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>Fórmula:C21H21FN4O3Pureza:98.76%Forma y color:SolidPeso molecular:396.41DNMT-IN-3
CAS:<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Fórmula:C37H39N7OForma y color:SolidPeso molecular:597.75MPI_5a
CAS:<p>MPI_5a selectively inhibits HDAC6 (IC50=36 nM), slightly affects other HDACs, and blocks acyl-tubulin build-up (IC50=210 nM).</p>Fórmula:C16H17N3O3Pureza:99.62%Forma y color:SolidPeso molecular:299.32DNA-PK-IN-10
CAS:<p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>Fórmula:C25H28N6O2Pureza:98%Forma y color:SolidPeso molecular:444.539-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:<p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>Fórmula:C22H18ClFN2O4Pureza:98%Forma y color:SolidPeso molecular:428.84SRT3657
CAS:<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Fórmula:C40H54N8O6SPureza:98%Forma y color:SolidPeso molecular:774.97NH2-methylpropanamide-Exatecan TFA
CAS:<p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>Fórmula:C30H30F4N4O7Pureza:98%Forma y color:SolidPeso molecular:634.58DY-46-2
CAS:<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Fórmula:C19H22N6O5SPureza:99.12% - 99.12%Forma y color:SolidPeso molecular:446.48HDAC/BET-IN-1
CAS:<p>HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.</p>Fórmula:C29H40N4O8SPureza:98%Forma y color:SolidPeso molecular:604.71Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Fórmula:C21H19F3N4O6SPureza:99.18%Forma y color:SolidPeso molecular:512.46NT160
CAS:<p>NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.</p>Fórmula:C21H21F3N4O2Pureza:99.3%Forma y color:SolidPeso molecular:418.41Antipsychotic agent 54
CAS:<p>Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM).</p>Fórmula:C21H23FN2O4Pureza:98.10%Forma y color:SolidPeso molecular:386.42HDAC6-IN-8
CAS:<p>Compound 12C, with altered cap groups, shows wide-range enzyme inhibition; 9m and 9q target HDAC6 specifically.</p>Fórmula:C23H17BrFN5O3Pureza:98%Forma y color:SolidPeso molecular:510.32Bocodepsin
CAS:<p>Bocodepsin (OKI-179) is a selective, orally active inhibitor of histone deacetylases (HDAC) with demonstrated antitumor efficacy.</p>Fórmula:C26H39N5O6S2Pureza:98%Forma y color:SolidPeso molecular:581.75ATR-IN-29
CAS:<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Fórmula:C19H22N8OPureza:98%Forma y color:SolidPeso molecular:378.43Zabofloxacin
CAS:<p>Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.</p>Fórmula:C19H20FN5O4Pureza:98%Forma y color:SolidPeso molecular:401.3910-Nitrolinoleic acid
CAS:<p>10-Nitrolinoleate, a nitration product of linoleate, modulates PPARγ, enhancing glucose uptake, and aids in muscle relaxation via NO/cGMP pathway.</p>Fórmula:C18H31NO4Forma y color:SolidPeso molecular:325.44WAY-354574
CAS:<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Fórmula:C20H23ClN2O3SPureza:98%Forma y color:SolidPeso molecular:406.93PARP7-IN-16
CAS:<p>PARP7-IN-16 (compound 36) is a potent, selective, and orally active PARP-1/2/7 inhibitor, exhibiting IC50 values of 0.94, 0.87, and 0.21 nM , respectively.</p>Fórmula:C25H26FN4NaO4Pureza:98%Forma y color:SolidPeso molecular:488.49SDOX
CAS:<p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>Fórmula:C69H97NO20S2Pureza:98%Forma y color:SolidPeso molecular:1324.63Furegrelate sodium
CAS:<p>Furegrelate sodium (U-63557A) is an orally active thromboxane synthase inhibitor with an IC50 of 15 nM in platelets.</p>Fórmula:C15H10NNaO3Pureza:99.92%Forma y color:SolidPeso molecular:275.23Lexitropsin 1
CAS:<p>Lexitropsin 1 is a new anticancer drug.</p>Fórmula:C15H19N7O3SPureza:98%Forma y color:SolidPeso molecular:377.427-Deaza-2′-deoxyguanosine 5′-triphosphate
CAS:<p>7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].</p>Fórmula:C11H17N4O13P3Pureza:98%Forma y color:SolidPeso molecular:506.19(S)-Ceralasertib
CAS:<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Fórmula:C20H24N6O2SForma y color:SolidPeso molecular:412.51ATR-IN-18
CAS:<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Fórmula:C19H22F3N7O5SForma y color:SolidPeso molecular:517.48Prostaglandin B3
CAS:<p>Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].</p>Fórmula:C20H28O4Forma y color:SolidPeso molecular:332.43Ambamustine
CAS:<p>Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.</p>Fórmula:C29H39Cl2FN4O4SPureza:98%Forma y color:SolidPeso molecular:629.61ATR-IN-8
CAS:<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Fórmula:C20H22N6O2SForma y color:SolidPeso molecular:410.49Oxamflatin
CAS:<p>Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).</p>Fórmula:C17H14N2O4SPureza:98.25%Forma y color:SolidPeso molecular:342.37KD-3010
CAS:<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Fórmula:C30H33F3N2O8S2Pureza:99.61%Forma y color:SolidPeso molecular:670.72Nesuparib
CAS:<p>Nesuparib, a potent PARP/TNKS1 inhibitor, has antitumor properties and potential for treating various diseases.</p>Fórmula:C23H24N6OPureza:99.71%Forma y color:SolidPeso molecular:400.48KPZ560
CAS:<p>KPZ560, a potent HDAC 1 and HDAC 2 inhibitor, exhibits IC50 values of 12 nM and 68 nM, respectively.</p>Fórmula:C26H21N5O3S2Pureza:98%Forma y color:SolidPeso molecular:515.61AZD4619
CAS:<p>AZD4619 is a potent, selective and reversible orally bioavailable agonist of PPARα receptor.</p>Fórmula:C25H26O8S2Forma y color:SolidPeso molecular:518.6BM152054
CAS:<p>BM152054 is a potent PPARγ ligand that induces glucose utilization in peripheral tissues by enhancing insulin action.</p>Fórmula:C22H18N2O4S3Pureza:99.56%Forma y color:SolidPeso molecular:470.58Sipoglitazar
CAS:<p>Sipoglitazar, a PPARγ agonist, is used potentially for the treatment of diabetes.</p>Fórmula:C25H25N3O4SPureza:98%Forma y color:SolidPeso molecular:463.55Sirtuin modulator 1
CAS:<p>Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.</p>Fórmula:C31H32ClN5O2S2Pureza:99.63%Forma y color:SolidPeso molecular:606.2SIRT-IN-1
CAS:<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Fórmula:C19H27N5O2SPureza:99.29%Forma y color:SolidPeso molecular:389.52Ac-Exatecan
CAS:<p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>Fórmula:C26H24FN3O5Pureza:97.09%Forma y color:SolidPeso molecular:477.48ZL-2201
CAS:<p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>Fórmula:C20H25N9O5SPureza:98%Forma y color:SolidPeso molecular:503.54PARP7-IN-15
CAS:<p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>Fórmula:C23H24F6N6O4Pureza:98%Forma y color:SolidPeso molecular:562.46ATR-IN-6
CAS:<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Fórmula:C28H28FN7O2Forma y color:SolidPeso molecular:513.57E7016
CAS:<p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>Fórmula:C20H19N3O3Pureza:99.02%Forma y color:SolidPeso molecular:349.38IACS-52825
CAS:<p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>Fórmula:C16H13F7N4O2Pureza:99.77%Forma y color:SolidPeso molecular:426.29CGS 15435
CAS:<p>CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.</p>Fórmula:C20H21ClN2O2Pureza:99.86%Forma y color:SolidPeso molecular:356.85PARP-1-IN-4
CAS:<p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>Fórmula:C22H15Cl2N3O2Pureza:99.82%Forma y color:SolidPeso molecular:424.28Lartesertib
CAS:<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Fórmula:C23H21FN6O3Pureza:99.9%Forma y color:SolidPeso molecular:448.45AZ31
CAS:<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Fórmula:C24H28N4O3Pureza:98.01%Forma y color:SolidPeso molecular:420.5
