Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(51 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
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Se han encontrado 958 productos de "Daño al ADN / Reparación del ADN"
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Ragaglitazar
CAS:<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Fórmula:C25H25NO5Pureza:97.46% - 98.56%Forma y color:SolidPeso molecular:419.47Camonsertib
CAS:<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Fórmula:C21H26N6O3Pureza:99.6% - 99.93%Forma y color:SolidPeso molecular:410.47E-3030 free acid
CAS:<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Fórmula:C22H23ClFNO5Pureza:98%Forma y color:SolidPeso molecular:435.87ATM Inhibitor-1
CAS:<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Fórmula:C27H36N6O3Pureza:98%Forma y color:SolidPeso molecular:492.61PPARγ agonist 1
<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>Fórmula:C34H39NO3Forma y color:SolidPeso molecular:509.68TP3011
CAS:<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Fórmula:C26H26N4O5Pureza:98%Forma y color:SolidPeso molecular:474.51G-631
CAS:<p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>Fórmula:C19H22F2N6O3Forma y color:SolidPeso molecular:420.41(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Fórmula:C19H14N2O4Forma y color:SolidPeso molecular:334.326TMU 35435
CAS:<p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>Fórmula:C22H25N3O3Forma y color:SolidPeso molecular:379.45Antibacterial agent 236
CAS:<p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>Fórmula:C26H27N5O2SForma y color:SolidPeso molecular:473.59Carbacyclin
CAS:<p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>Fórmula:C21H34O4Pureza:98%Forma y color:SolidPeso molecular:350.49ATR kinase-IN-3
CAS:<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Fórmula:C24H27F2N9O2Forma y color:SolidPeso molecular:511.53PARP1/2-IN-4
CAS:<p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>Fórmula:C23H30FN5O6Forma y color:SolidPeso molecular:491.51Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Fórmula:C28H46N8O6SForma y color:SolidPeso molecular:622.78SIRT6 activator 2
CAS:<p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>Fórmula:C23H23N3O6Forma y color:SolidPeso molecular:437.45Bizelesin
CAS:<p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>Fórmula:C43H36Cl2N8O5Forma y color:SolidPeso molecular:815.7ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54Topoisomerase I inhibitor 8
CAS:<p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>Fórmula:C24H21FN2O4Forma y color:SolidPeso molecular:420.43ATR kinase-IN-2
CAS:<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Fórmula:C24H29F2N9O2Forma y color:SolidPeso molecular:513.54PPARα/δ agonist 3
CAS:<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Fórmula:C23H25F3N2O4Forma y color:SolidPeso molecular:450.451PPARγ-IN-5
CAS:<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Fórmula:C22H23ClO7Forma y color:SolidPeso molecular:434.867O6BTG-C8-αGlu
CAS:<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Fórmula:C24H34BrN5O7SForma y color:SolidPeso molecular:616.525ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Fórmula:C22H27N5O3SForma y color:SolidPeso molecular:441.55RU-0415529
CAS:<p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>Fórmula:C21H29N3O4SForma y color:SolidPeso molecular:419.538ATR-IN-19
CAS:<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Fórmula:C18H19N7OSForma y color:SolidPeso molecular:381.45Amezalpat
CAS:<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Fórmula:C34H41N3O4Forma y color:SolidPeso molecular:555.707(1R,2S,7R)-Sitafloxacin
CAS:<p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>Fórmula:C19H18ClF2N3O3Forma y color:SolidPeso molecular:409.814Camptothecin-20(S)-O-propionate
CAS:<p>CZ-48 is a DNA topoisomerase inhibitor.</p>Fórmula:C23H20N2O5Forma y color:SolidPeso molecular:404.42Pparδ agonist 5
<p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>Fórmula:C23H21F3N2O2SForma y color:SolidPeso molecular:446.49(S)-WSD0628
CAS:<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.458(1S,2R,7S)-Sitafloxacin
CAS:<p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>Fórmula:C19H18ClF2N3O3Forma y color:SolidPeso molecular:409.81PARP1-IN-30
CAS:<p>PARP1-IN-30 is a specific and effective PARP1 inhibitor with cytotoxic properties. It precisely inhibits PARP1 in tumor cells lacking breast cancer 1 protein (BRCA1) or BRCA2. PARP1-IN-30 holds potential for use in cancer research.</p>Fórmula:C14H12ClNO4SForma y color:SolidPeso molecular:325.77PPARγ modulator-2
CAS:<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Fórmula:C26H21NO7S3SeForma y color:SolidPeso molecular:634.6ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Fórmula:C26H31N7O3Forma y color:SolidPeso molecular:489.57TERT activator-2
CAS:<p>TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.</p>Fórmula:C21H22N2O2Forma y color:SolidPeso molecular:334.412DNA crosslinker 2 dihydrochloride
CAS:<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29TH1338
CAS:<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Fórmula:C22H21N3O4Pureza:98.77%Forma y color:SolidPeso molecular:391.42DNA crosslinker 3 dihydrochloride
CAS:<p>Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29DNA crosslinker 1 dihydrochloride
CAS:<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29ATM Inhibitor-11
CAS:<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Fórmula:C27H33FN6O2Forma y color:SolidPeso molecular:492.59Atiratecan
CAS:<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Fórmula:C31H34N6O6Pureza:98%Forma y color:SolidPeso molecular:586.64DNA-PK-IN-2
CAS:<p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>Fórmula:C20H23N5O3Forma y color:SolidPeso molecular:381.43KSQ-4279 (gentisate)
CAS:<p>KSQ-4279 (gentisate) (Compound Formula I) serves as an effective inhibitor of USP1 and a selective inhibitor of PARP1. This compound shows promise for use in cancer research.</p>Fórmula:C34H31F3N8O5Forma y color:SolidPeso molecular:688.66DNA-PK-IN-15
CAS:<p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>Fórmula:C23H23N9OForma y color:SolidPeso molecular:441.49HDAC6-IN-51
CAS:HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Fórmula:C24H24ClN5O3Forma y color:SolidPeso molecular:465.93Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Fórmula:C17H11Cl2F3N2O3SForma y color:SolidPeso molecular:451.25TDI-015051
CAS:<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Fórmula:C22H22FN5O4SForma y color:SolidPeso molecular:471.505ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Fórmula:C25H29FN6O3Forma y color:SolidPeso molecular:480.53Topoisomerase II inhibitor 6
<p>Topoisomerase II inhibitor 6, a potent tryptanthrin derivative, blocks G2 phase in CCRF-CEM cells, induces DNA breaks, and may be used for cancer research.</p>Fórmula:C19H18N4O2Forma y color:SolidPeso molecular:334.37DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Fórmula:C20H24F3N5O2Forma y color:SolidPeso molecular:423.43
