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Daño al ADN / Reparación del ADN

Daño al ADN / Reparación del ADN

Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.

Subcategorías de "Daño al ADN / Reparación del ADN"

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Se han encontrado 962 productos de "Daño al ADN / Reparación del ADN"

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  • EB-47
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    EB-47

    CAS:
    <p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>
    Fórmula:C24H27N9O6
    Pureza:99.81%
    Forma y color:Solid
    Peso molecular:537.53

    Ref: TM-T11143

  • CEP-9722
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    CEP-9722

    CAS:
    <p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>
    Fórmula:C24H26N4O3
    Pureza:98.38% - 98.56%
    Forma y color:Solid
    Peso molecular:418.49

    Ref: TM-T62196

  • ACY-957
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    ACY-957

    CAS:
    <p>ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.</p>
    Fórmula:C24H23N5OS
    Pureza:99.79%
    Forma y color:Solid
    Peso molecular:429.54

    Ref: TM-T10245

  • ACY-1083
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    ACY-1083

    CAS:
    <p>ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.</p>
    Fórmula:C17H18F2N4O2
    Pureza:99.19% - 99.43%
    Forma y color:Solid
    Peso molecular:348.35

    Ref: TM-T10244

  • Ac-Exatecan
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    Ac-Exatecan

    CAS:
    <p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>
    Fórmula:C26H24FN3O5
    Pureza:97.09%
    Forma y color:Solid
    Peso molecular:477.48

    Ref: TM-T77901

  • GNE-8505
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    GNE-8505

    CAS:
    <p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>
    Fórmula:C21H24F3N5O
    Forma y color:Solid
    Peso molecular:419.44

    Ref: TM-T11440

  • PPARγ agonist 7
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    PPARγ agonist 7

    CAS:
    <p>PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ).</p>
    Fórmula:C20H30O6
    Forma y color:Solid
    Peso molecular:366.45

    Ref: TM-T61417

  • SIRT-IN-1
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    SIRT-IN-1

    CAS:
    <p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>
    Fórmula:C19H27N5O2S
    Pureza:99.29%
    Forma y color:Solid
    Peso molecular:389.52

    Ref: TM-T12918

  • Epigenetic factor-IN-1
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    Epigenetic factor-IN-1

    CAS:
    <p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>
    Fórmula:C32H34FN5O6S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:667.77

    Ref: TM-T82458

  • Duocarmycin analog-2
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    Duocarmycin analog-2

    CAS:
    <p>Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.</p>
    Fórmula:C29H23ClN4O3
    Forma y color:Solid
    Peso molecular:510.97

    Ref: TM-T63523

  • Prostaglandin B3
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    Prostaglandin B3

    CAS:
    <p>Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].</p>
    Fórmula:C20H28O4
    Forma y color:Solid
    Peso molecular:332.43

    Ref: TM-T84583

  • PR-104A
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    PR-104A

    CAS:
    <p>PR-104A is a hypoxia-targeted anticancer agent.</p>
    Fórmula:C14H19BrN4O9S
    Forma y color:Solid
    Peso molecular:499.29

    Ref: TM-T28447

  • TP0480066
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    TP0480066

    CAS:
    <p>TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.</p>
    Fórmula:C18H14FN3O5
    Forma y color:Solid
    Peso molecular:371.32

    Ref: TM-T61481

  • KRP-101
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    KRP-101

    CAS:
    <p>KRP-101, a PPARɑ agonist, is used potentially for the treatment of diabetes and hyperlipidaemia.</p>
    Fórmula:C26H26FNO5
    Forma y color:Solid
    Peso molecular:451.49

    Ref: TM-T27746

  • ARN-21934
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    ARN-21934

    CAS:
    <p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>
    Fórmula:C21H24N6
    Pureza:99.8%
    Forma y color:Solid
    Peso molecular:360.46

    Ref: TM-T36968

  • Peliglitazar
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    Peliglitazar

    CAS:
    <p>Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor.</p>
    Fórmula:C30H30N2O7
    Forma y color:Solid
    Peso molecular:530.57

    Ref: TM-T28354

  • DNA-PK-IN-10
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    DNA-PK-IN-10

    CAS:
    <p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>
    Fórmula:C25H28N6O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:444.53

    Ref: TM-T79165

  • ATR-IN-13
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    ATR-IN-13

    CAS:
    <p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>
    Fórmula:C24H24FN9O
    Forma y color:Solid
    Peso molecular:473.51

    Ref: TM-T63066

  • L-783483
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    L-783483

    CAS:
    <p>L-783483 is an agonist of PPAR.</p>
    Fórmula:C22H21ClF3NO4S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:487.92

    Ref: TM-T27784

  • SR 2595
    Targetmol
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    SR 2595

    CAS:
    <p>SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1].</p>
    Fórmula:C37H38N2O3
    Forma y color:Solid
    Peso molecular:558.71

    Ref: TM-T22154