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Daño al ADN / Reparación del ADN

Daño al ADN / Reparación del ADN

Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.

Subcategorías de "Daño al ADN / Reparación del ADN"

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Se han encontrado 958 productos de "Daño al ADN / Reparación del ADN"

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  • Carbacyclin
    Targetmol
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    Carbacyclin

    CAS:
    <p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>
    Fórmula:C21H34O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:350.49

    Ref: TM-T10673

  • ATR kinase-IN-3
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    ATR kinase-IN-3

    CAS:
    <p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>
    Fórmula:C24H27F2N9O2
    Forma y color:Solid
    Peso molecular:511.53

    Ref: TM-T201805

  • PARP1/2-IN-4
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    PARP1/2-IN-4

    CAS:
    <p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>
    Fórmula:C23H30FN5O6
    Forma y color:Solid
    Peso molecular:491.51

    Ref: TM-T201607

  • Sirtuin-IN-2
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    Sirtuin-IN-2

    <p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>
    Fórmula:C28H46N8O6S
    Forma y color:Solid
    Peso molecular:622.78

    Ref: TM-T201797

  • SIRT6 activator 2
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    SIRT6 activator 2

    CAS:
    <p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>
    Fórmula:C23H23N3O6
    Forma y color:Solid
    Peso molecular:437.45

    Ref: TM-T200625

  • Bizelesin
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    Bizelesin

    CAS:
    <p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>
    Fórmula:C43H36Cl2N8O5
    Forma y color:Solid
    Peso molecular:815.7

    Ref: TM-T71034

  • Logo de CymitQuimica
    Targetmol
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    ATR-IN-11

    <p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>
    Fórmula:C25H30N6O2
    Forma y color:Solid
    Peso molecular:446.54

    Ref: TM-T62651

  • Topoisomerase I inhibitor 8
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    Topoisomerase I inhibitor 8

    CAS:
    <p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>
    Fórmula:C24H21FN2O4
    Forma y color:Solid
    Peso molecular:420.43

    Ref: TM-T62225

  • ATR kinase-IN-2
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    ATR kinase-IN-2

    CAS:
    <p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>
    Fórmula:C24H29F2N9O2
    Forma y color:Solid
    Peso molecular:513.54

    Ref: TM-T201634

  • PPARα/δ agonist 3
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    PPARα/δ agonist 3

    CAS:
    <p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>
    Fórmula:C23H25F3N2O4
    Forma y color:Solid
    Peso molecular:450.451

    Ref: TM-T205373

  • PPARγ-IN-5
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    PPARγ-IN-5

    CAS:
    <p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>
    Fórmula:C22H23ClO7
    Forma y color:Solid
    Peso molecular:434.867

    Ref: TM-T205246

  • O6BTG-C8-αGlu
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    O6BTG-C8-αGlu

    CAS:
    <p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>
    Fórmula:C24H34BrN5O7S
    Forma y color:Solid
    Peso molecular:616.525

    Ref: TM-T205643

  • Logo de CymitQuimica
    Targetmol
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    ATR-IN-12

    <p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>
    Fórmula:C22H27N5O3S
    Forma y color:Solid
    Peso molecular:441.55

    Ref: TM-T62563

  • RU-0415529
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    RU-0415529

    CAS:
    <p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>
    Fórmula:C21H29N3O4S
    Forma y color:Solid
    Peso molecular:419.538

    Ref: TM-T204295

  • ATR-IN-19
    Targetmol
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    ATR-IN-19

    CAS:
    <p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>
    Fórmula:C18H19N7OS
    Forma y color:Solid
    Peso molecular:381.45

    Ref: TM-T61636

  • Amezalpat
    Targetmol
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    Amezalpat

    CAS:
    <p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>
    Fórmula:C34H41N3O4
    Forma y color:Solid
    Peso molecular:555.707

    Ref: TM-T205015

  • (1R,2S,7R)-Sitafloxacin
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    (1R,2S,7R)-Sitafloxacin

    CAS:
    <p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>
    Fórmula:C19H18ClF2N3O3
    Forma y color:Solid
    Peso molecular:409.814

    Ref: TM-T206262

  • Camptothecin-20(S)-O-propionate
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    Camptothecin-20(S)-O-propionate

    CAS:
    <p>CZ-48 is a DNA topoisomerase inhibitor.</p>
    Fórmula:C23H20N2O5
    Forma y color:Solid
    Peso molecular:404.42

    Ref: TM-T27113

  • Logo de CymitQuimica
    Targetmol
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    Pparδ agonist 5

    <p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>
    Fórmula:C23H21F3N2O2S
    Forma y color:Solid
    Peso molecular:446.49

    Ref: TM-T62646

  • (S)-WSD0628
    Targetmol
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    (S)-WSD0628

    CAS:
    <p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>
    Fórmula:C23H23F2N5O2
    Forma y color:Solid
    Peso molecular:439.458

    Ref: TM-T205268