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Daño al ADN / Reparación del ADN

Daño al ADN / Reparación del ADN

Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.

Subcategorías de "Daño al ADN / Reparación del ADN"

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Se han encontrado 958 productos de "Daño al ADN / Reparación del ADN"

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  • Ac-Exatecan
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    Ac-Exatecan

    CAS:
    <p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>
    Fórmula:C26H24FN3O5
    Pureza:97.09%
    Forma y color:Solid
    Peso molecular:477.48

    Ref: TM-T77901

  • ZL-2201
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    ZL-2201

    CAS:
    <p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>
    Fórmula:C20H25N9O5S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:503.54

    Ref: TM-T78645

  • PARP7-IN-15
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    PARP7-IN-15

    CAS:
    <p>PARP7-IN-15 (Compound 18) is a potent PARP7 inhibitor exhibiting an IC50 of 0.56 nM and demonstrates antitumor activity [1].</p>
    Fórmula:C23H24F6N6O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:562.46

    Ref: TM-T81542

  • ATR-IN-6
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    ATR-IN-6

    CAS:
    <p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>
    Fórmula:C28H28FN7O2
    Forma y color:Solid
    Peso molecular:513.57

    Ref: TM-T63555

  • E7016
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    E7016

    CAS:
    <p>E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.</p>
    Fórmula:C20H19N3O3
    Pureza:99.02%
    Forma y color:Solid
    Peso molecular:349.38

    Ref: TM-T61189

  • IACS-52825
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    IACS-52825

    CAS:
    <p>IACS-52825 is a DLK inhibitor that reverses para-mechanical aberrant pain in a CIPN mouse model and can be used to study neurological disorders.</p>
    Fórmula:C16H13F7N4O2
    Pureza:99.77%
    Forma y color:Solid
    Peso molecular:426.29

    Ref: TM-T79303

  • CGS 15435
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    CGS 15435

    CAS:
    <p>CGS 15435: potent TxA2 synthase inhibitor, IC50=1 nM; less selective for PGI2 synthase, COX, and liposynthase.</p>
    Fórmula:C20H21ClN2O2
    Pureza:99.86%
    Forma y color:Solid
    Peso molecular:356.85

    Ref: TM-T10783

  • PARP-1-IN-4
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    PARP-1-IN-4

    CAS:
    <p>PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.</p>
    Fórmula:C22H15Cl2N3O2
    Pureza:99.82%
    Forma y color:Solid
    Peso molecular:424.28

    Ref: TM-T78182

  • Lartesertib
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    Lartesertib

    CAS:
    <p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>
    Fórmula:C23H21FN6O3
    Pureza:99.9%
    Forma y color:Solid
    Peso molecular:448.45

    Ref: TM-T62684

  • AZ31
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    AZ31

    CAS:
    <p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of &lt;1.2 nM and 46 nM,</p>
    Fórmula:C24H28N4O3
    Pureza:98.01%
    Forma y color:Solid
    Peso molecular:420.5

    Ref: TM-T19671

  • Ragaglitazar
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    Ragaglitazar

    CAS:
    <p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>
    Fórmula:C25H25NO5
    Pureza:97.46% - 98.56%
    Forma y color:Solid
    Peso molecular:419.47

    Ref: TM-T28501

  • Camonsertib
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    Camonsertib

    CAS:
    <p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>
    Fórmula:C21H26N6O3
    Pureza:99.6% - 99.93%
    Forma y color:Solid
    Peso molecular:410.47

    Ref: TM-T62083

  • E-3030 free acid
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    E-3030 free acid

    CAS:
    <p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>
    Fórmula:C22H23ClFNO5
    Pureza:98%
    Forma y color:Solid
    Peso molecular:435.87

    Ref: TM-T27228

  • ATM Inhibitor-1
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    ATM Inhibitor-1

    CAS:
    <p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>
    Fórmula:C27H36N6O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:492.61

    Ref: TM-T10396

  • Logo de CymitQuimica
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    PPARγ agonist 1

    <p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>
    Fórmula:C34H39NO3
    Forma y color:Solid
    Peso molecular:509.68

    Ref: TM-T63514

  • TP3011
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    TP3011

    CAS:
    <p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>
    Fórmula:C26H26N4O5
    Pureza:98%
    Forma y color:Solid
    Peso molecular:474.51

    Ref: TM-T13191

  • G-631
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    G-631

    CAS:
    <p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>
    Fórmula:C19H22F2N6O3
    Forma y color:Solid
    Peso molecular:420.41

    Ref: TM-T200085

  • (Rac)-RG108
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    (Rac)-RG108

    CAS:
    <p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>
    Fórmula:C19H14N2O4
    Forma y color:Solid
    Peso molecular:334.326

    Ref: TM-T206761

  • TMU 35435
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    TMU 35435

    CAS:
    <p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>
    Fórmula:C22H25N3O3
    Forma y color:Solid
    Peso molecular:379.45

    Ref: TM-T200171

  • Antibacterial agent 236
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    Antibacterial agent 236

    CAS:
    <p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>
    Fórmula:C26H27N5O2S
    Forma y color:Solid
    Peso molecular:473.59

    Ref: TM-T200041