ADN-PK
La DNA-PK (quinasa dependiente de ADN) es una enzima clave involucrada en la reparación de rupturas de doble hebra de ADN a través de la vía de unión de extremos no homólogos (NHEJ). Los inhibidores de DNA-PK bloquean la actividad de esta quinasa, impidiendo la reparación de rupturas de ADN y provocando un aumento en la muerte celular, particularmente en células cancerosas. Los inhibidores de DNA-PK son herramientas valiosas en la investigación y terapia contra el cáncer, especialmente en combinación con otros tratamientos que dañan el ADN. En CymitQuimica, ofrecemos una gama completa de inhibidores de DNA-PK de alta calidad para apoyar su investigación en reparación de ADN, biología del cáncer y desarrollo terapéutico.
Se han encontrado 48 productos de "ADN-PK"
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STL127705
CAS:STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.Fórmula:C22H20FN5O4Pureza:99.53% - 99.81%Forma y color:SolidPeso molecular:437.42Ref: TM-T13017
1mg73,00€5mg159,00€10mg230,00€25mg390,00€50mg582,00€100mg762,00€1mL*10mM (DMSO)178,00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Fórmula:C24H18N2O3SPureza:99.34%Forma y color:SolidPeso molecular:414.48Ref: TM-T15789
5mg46,00€10mg74,00€25mg145,00€50mg245,00€100mg364,00€200mg532,00€1mL*10mM (DMSO)49,00€(R)-VX-984
CAS:(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.Fórmula:C23H21D2N7OPureza:98%Forma y color:SolidPeso molecular:415.49Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Forma y color:Odour SolidDNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Forma y color:Odour SolidIC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Fórmula:C12H15NO3Pureza:99.68%Forma y color:SolidPeso molecular:221.25AMA-37
CAS:AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.Fórmula:C17H17NO3Pureza:98%Forma y color:SolidPeso molecular:283.32Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Fórmula:C21H25F3N6O2Pureza:99.88%Forma y color:SolidPeso molecular:450.46NU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFórmula:C17H15NO3Pureza:99.51% - >99.99%Forma y color:SolidPeso molecular:281.31CC-115 hydrochloride
CAS:CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.Fórmula:C16H17ClN8OForma y color:SolidPeso molecular:372.82PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:97.79% - 99.3%Forma y color:SolidPeso molecular:348.36KU-57788
CAS:NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).Fórmula:C25H19NO3SPureza:98% - >99.99%Forma y color:SolidPeso molecular:413.49AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Forma y color:SolidPeso molecular:380.4Ref: TM-T7122
1mg40,00€5mg88,00€10mg119,00€25mg187,00€50mg311,00€100mg472,00€200mg687,00€1mL*10mM (DMSO)87,00€PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82%Forma y color:SolidPeso molecular:488.74PIK-90
CAS:<p>PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .</p>Fórmula:C18H17N5O3Pureza:98.25% - ≥95%Forma y color:SolidPeso molecular:351.36Compound 401
CAS:Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.Fórmula:C16H15N3O2Pureza:99.73% - 99.78%Forma y color:SolidPeso molecular:281.31Ref: TM-T3586
2mg34,00€5mg49,00€10mg65,00€25mg116,00€50mg215,00€100mg319,00€200mg455,00€1mL*10mM (DMSO)58,00€DMNB
CAS:DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.Fórmula:C9H9NO5Pureza:97.87%Forma y color:Yellow SolidPeso molecular:211.17PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Fórmula:C27H31FN6OSPureza:99.84% - ≥95%Forma y color:SolidPeso molecular:506.64LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Fórmula:C19H17NO3Pureza:98% - 99.96%Forma y color:Pale Yellow SolidPeso molecular:307.34Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Fórmula:C24H15F3N4OPureza:98.31% - 99.32%Forma y color:SolidPeso molecular:432.4
