ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 460 productos de "ADN metiltransferasa"
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1-Hydrazinophthalazine Hydrochloride
CAS:Fórmula:C8H8N4·HClPureza:>99.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:196.64Genistein
CAS:Fórmula:C15H10O5Pureza:>98.0%(HPLC)Forma y color:White to Light yellow to Light orange powder to crystalPeso molecular:270.245-Azacytidine
CAS:Fórmula:C8H12N4O5Pureza:>98.0%(T)Forma y color:White to Almost white powder to crystalPeso molecular:244.21Caffeic Acid
CAS:Fórmula:C9H8O4Pureza:>98.0%(T)(HPLC)Forma y color:White to Orange to Green powder to crystalPeso molecular:180.165-Aza-2'-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:228.21Chlorogenic Acid
CAS:Fórmula:C16H18O9Pureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:354.31N-Phthalyl-L-tryptophan
CAS:Fórmula:C19H14N2O4Pureza:>98.0%(T)(HPLC)Forma y color:Light yellow to Amber to Dark green powder to crystalinePeso molecular:334.33(-)-Epigallocatechin Gallate Hydrate
CAS:Fórmula:C22H18O11·xH2OPureza:>98.0%(HPLC)Forma y color:White to Light yellow to Light orange powder to crystalPeso molecular:458.38 (as Anhydrous)Procaine Hydrochloride
CAS:Fórmula:C13H20N2O2·HClPureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:272.77Zebularine
CAS:Fórmula:C9H12N2O5Pureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:228.20Valemetostat
CAS:Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.Fórmula:C26H34ClN3O4Pureza:98.38% - 99.83%Forma y color:SolidPeso molecular:488.02Ref: TM-T13279L
1mg89,00€5mg177,00€10mg313,00€25mg520,00€50mg742,00€100mg982,00€1mL*10mM (DMSO)197,00€5-Azacytidine
CAS:5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.Fórmula:C8H12N4O5Pureza:98% - 99.79%Forma y color:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:244.2Levetiracetam
CAS:Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onsetFórmula:C8H14N2O2Pureza:99.67% - 99.86%Forma y color:White Crystalline PowderPeso molecular:170.21(E)-3,4-dihydroxycinnamic acid
CAS:Fórmula:C9H8O4Pureza:98%Forma y color:SolidPeso molecular:180.15744-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O5Pureza:98%Forma y color:SolidPeso molecular:244.2047Diperodon hydrochloride
CAS:Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.Fórmula:C22H28ClN3O4Pureza:99.91%Forma y color:SolidPeso molecular:433.93Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Fórmula:C9H16N4O7Pureza:>99.99%Forma y color:SolidPeso molecular:292.254-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O4Pureza:98%Forma y color:SolidPeso molecular:228.2053Amodiaquine dihydrochloride dihydrate
CAS:Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effectsFórmula:C20H28Cl3N3O3Pureza:99.97%Forma y color:SolidPeso molecular:464.82(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS:Fórmula:C16H18O9Pureza:98%Forma y color:SolidPeso molecular:354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgA consultar25g153,00€100g489,00€250gA consultar500gA consultar50kg41.345,00€250mg26,00€2(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
CAS:Fórmula:C9H12N2O5Pureza:98%Forma y color:SolidPeso molecular:228.2020Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS:Fórmula:C8H9ClN4Pureza:98%Forma y color:SolidPeso molecular:196.6369A-395
CAS:A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.Fórmula:C26H35FN4O2SPureza:98.43%Forma y color:SolidPeso molecular:486.654H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS:Fórmula:C15H10O5Pureza:97%Forma y color:SolidPeso molecular:270.2369Ref: IN-DA00I8G3
1g26,00€5g24,00€10g31,00€1kg686,00€25g52,00€50g77,00€5kgA consultar100g114,00€10kgA consultar250g181,00€500g320,00€100mg26,00€Decitabine
CAS:Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Fórmula:C8H12N4O4Pureza:98.06% - 99.87%Forma y color:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecular:228.21MAK683
CAS:MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).Fórmula:C20H17FN6OPureza:98.25% - 99.92%Forma y color:SolidPeso molecular:376.39Ref: TM-T15201
1mg50,00€5mg102,00€10mg178,00€25mg389,00€50mg575,00€100mg802,00€500mg1.665,00€1mL*10mM (DMSO)89,00€EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Fórmula:C34H48N4O4Pureza:99.74%Forma y color:SolidPeso molecular:576.77iso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Fórmula:C22H24ClN3O2SPureza:99.53% - 99.89%Forma y color:SoildPeso molecular:429.96Tulmimetostat
CAS:Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advancedFórmula:C28H36ClN3O5SPureza:98.04% - 99.872%Forma y color:SolidPeso molecular:562.12BVT948
CAS:BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.Fórmula:C14H11NO3Pureza:98.87%Forma y color:SolidPeso molecular:241.24Ref: TM-T14841
1mg38,00€2mg49,00€5mg80,00€10mg104,00€25mg157,00€50mg210,00€100mg338,00€1mL*10mM (DMSO)88,00€DC-05
CAS:DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).Fórmula:C25H25N3OPureza:98.95%Forma y color:SolidPeso molecular:383.49Ref: TM-T15080
1mg66,00€5mg145,00€10mg236,00€25mg515,00€50mg858,00€100mg1.251,00€200mg1.684,00€1mL*10mM (DMSO)158,00€(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
CAS:Fórmula:C22H18O11Pureza:98%Forma y color:SolidPeso molecular:458.3717Ref: IN-DA00IK6L
1g22,00€5g24,00€10g31,00€1kg527,00€25g55,00€50g80,00€5kgA consultar100g114,00€250g177,00€500g302,00€A-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Fórmula:C29H38Cl2N4O4Forma y color:SolidPeso molecular:577.54PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Forma y color:SolidPeso molecular:1054.2PRMT5-IN-9
CAS:PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Fórmula:C25H23F3N6OForma y color:SolidPeso molecular:480.495Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Forma y color:SoildPeso molecular:499.75SW2_152F
SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.Fórmula:C45H62Cl3N7O8Forma y color:SolidPeso molecular:935.37WDR5-47
CAS:WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.Fórmula:C19H20ClFN4O3Pureza:98.15%Forma y color:SoildPeso molecular:406.84Ref: TM-T67697
1mg85,00€5mg170,00€10mg250,00€25mg371,00€50mg522,00€100mg712,00€200mg954,00€1mL*10mM (DMSO)185,00€UNC6852
CAS:UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.Fórmula:C43H48N10O6SPureza:96.64%Forma y color:SolidPeso molecular:832.97Ref: TM-T13954
1mg126,00€5mg260,00€10mg409,00€25mg660,00€50mg888,00€100mg1.224,00€1mL*10mM (DMSO)358,00€SAH-EZH2
CAS:EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Fórmula:C155H256N48O40Pureza:98%Forma y color:SolidPeso molecular:3432.05FTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Fórmula:C22H18FN5O2Forma y color:SolidPeso molecular:403.417UNC2399
CAS:UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC
Fórmula:C67H104N10O17SForma y color:SolidPeso molecular:1353.68ML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Forma y color:Odour SolidDot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Forma y color:Odour SolidBBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Fórmula:C37H47N5O5SForma y color:SolidPeso molecular:673.32979PRMT5-IN-11
CAS:PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Fórmula:C13H17N5O4Forma y color:SolidPeso molecular:307.31
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