ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 459 productos de "ADN metiltransferasa"
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EZH2-IN-9
CAS:EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.Fórmula:C28H32ClF2N3O5SForma y color:SolidPeso molecular:596.09AA-CW236
CAS:AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).Fórmula:C17H16ClF3N4O2Forma y color:SolidPeso molecular:400.78NSD3-IN-1
CAS:NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.Fórmula:C13H13N5OSForma y color:SolidPeso molecular:287.34BI-9321
CAS:BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Fórmula:C22H21FN4Pureza:98%Forma y color:SolidPeso molecular:360.43UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Fórmula:C25H36F3N5O4Forma y color:SolidPeso molecular:527.589DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Fórmula:C29H39Cl3FN9O3Forma y color:SolidPeso molecular:687.04SW155246
CAS:SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).Fórmula:C16H11ClN2O5SPureza:98.99%Forma y color:SolidPeso molecular:378.79TFMB-(S)-2-HG
CAS:TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.Fórmula:C13H11F3O4Pureza:98.07%Forma y color:SolidPeso molecular:288.22Ref: TM-T24871
2mg34,00€5mg50,00€10mg79,00€25mg146,00€50mg227,00€100mg339,00€500mg713,00€1mL*10mM (DMSO)49,00€PRMT5-IN-10
CAS:PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.Fórmula:C13H17N5O4Forma y color:SolidPeso molecular:307.31PRMT5-IN-2
CAS:PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.Fórmula:C17H16ClFN4O4Pureza:98%Forma y color:SolidPeso molecular:394.78EZH2-IN-7
CAS:EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.Fórmula:C31H37D2N5O3SForma y color:SolidPeso molecular:563.755-Aza-4'-thio-2'-deoxycytidine
CAS:5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].Fórmula:C8H12N4O3SForma y color:SolidPeso molecular:244.27G9a-IN-2
CAS:G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).Fórmula:C30H42N4O4Forma y color:SolidPeso molecular:522.68Lobelane Hydrochloride
CAS:Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.Fórmula:C22H30ClNForma y color:SolidPeso molecular:343.93Fagaronine chloride
CAS:Fagaronine chloride is a potent inhibitor of Topoisomerases I.Fórmula:C21H20ClNO4Forma y color:SolidPeso molecular:385.84DC_501
CAS:DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.Fórmula:C25H23Cl2N3OPureza:98%Forma y color:SolidPeso molecular:452.38Prospasmine
CAS:Prospasmine is an anticholinergic.Fórmula:C17H28ClNO2Pureza:98%Forma y color:SolidPeso molecular:313.87Setin-1
CAS:Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.Fórmula:C29H21F3N2O2Pureza:98%Forma y color:SolidPeso molecular:486.48DCE_254
CAS:DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.Fórmula:C21H17N9OSPureza:98%Forma y color:SolidPeso molecular:443.48GSK926
CAS:GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.Fórmula:C29H35N7O2Forma y color:SolidPeso molecular:513.63
