Sirtuin
Las sirtuinas son una familia de desacetilasas dependientes de NAD+ que desempeñan un papel crucial en la regulación de procesos celulares como la reparación del ADN, el envejecimiento, el metabolismo y la resistencia al estrés. Las sirtuinas influyen en la reparación del ADN desacetilando proteínas involucradas en las vías de reparación, modulando así su actividad. Los inhibidores y activadores de sirtuinas son herramientas valiosas en la investigación sobre el envejecimiento, el cáncer y las enfermedades metabólicas, donde la regulación de la reparación del ADN y la longevidad celular es de interés. En CymitQuimica, ofrecemos una gama de moduladores de sirtuinas de alta calidad para apoyar su investigación en reparación del ADN, envejecimiento celular y regulación metabólica.
Se han encontrado 88 productos de "Sirtuin"
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Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Fórmula:C11H15N2O5Pureza:98.82% - 99.58%Forma y color:SolidPeso molecular:255.25Resveratrol
CAS:<p>Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.</p>Fórmula:C14H12O3Pureza:99.82% - 99.96%Forma y color:Off-White To Tan PowderPeso molecular:228.24MC3482
CAS:<p>MC3482 is a specific inhibitor of sirtuin5 (SIRT5).</p>Fórmula:C33H38N4O8Pureza:98% - 99.90%Forma y color:SoildPeso molecular:618.68SIRT-IN-2
CAS:<p>SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).</p>Fórmula:C15H21N5O3S2Pureza:98.26%Forma y color:SolidPeso molecular:383.49SIRT5 inhibitor 9
CAS:<p>SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.</p>Fórmula:C24H29ClN8O4SPureza:98.68%Forma y color:SolidPeso molecular:561.06Z26395438
CAS:<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Fórmula:C17H15FN2OPureza:99.63%Forma y color:SolidPeso molecular:282.31Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Fórmula:C34H46N6O6SPureza:99.52%Forma y color:SolidPeso molecular:666.83SIRT-IN-5
<p>SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.</p>Forma y color:Odour SolidSIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Fórmula:C14H16N2OPureza:99.58%Forma y color:SolidPeso molecular:228.29SIRT5 inhibitor 8
CAS:<p>SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.</p>Fórmula:C22H25ClN8O2SPureza:99.56%Forma y color:SolidPeso molecular:501SIRT1 activator 1
<p>SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.</p>Pureza:98%Forma y color:Odour SolidSIRT2-IN-16
<p>SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).</p>Fórmula:C55H91N9O15SForma y color:SolidPeso molecular:1150.43BML-278
CAS:<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Fórmula:C24H25NO4Pureza:99.53%Forma y color:SolidPeso molecular:391.46SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SForma y color:SolidPeso molecular:492.5SJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Forma y color:Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:<p>3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.</p>Fórmula:C20H15N3O2SPureza:99.32%Forma y color:SolidPeso molecular:361.42SIRT2-IN-17
<p>SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.</p>Fórmula:C24H15N3O2SForma y color:SolidPeso molecular:409.46MIND4-19
CAS:<p>MIND4-19 is an inhibitor of SIRT2 with antitumor activity.</p>Fórmula:C22H19N3OSPureza:99.9%Forma y color:SolidPeso molecular:373.47Sirtuin modulator 2
CAS:<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>Fórmula:C19H15N3O2SPureza:99.67%Forma y color:SolidPeso molecular:349.41Sirt1/2-IN-4
<p>Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (</p>Fórmula:C21H20N4O3S2Pureza:98%Forma y color:SolidPeso molecular:440.54WAY-323061
CAS:<p>WAY-323061 is a SIRT2 inhibitor.</p>Fórmula:C25H21N5O2SPureza:99.33%Forma y color:SolidPeso molecular:455.53SIRT5 inhibitor 3
CAS:<p>SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .</p>Fórmula:C22H12FN3O4Pureza:98%Forma y color:SolidPeso molecular:401.35ADTL-SA1215
CAS:<p>ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.</p>Fórmula:C26H29I2NO3Pureza:99.23%Forma y color:SolidPeso molecular:657.32Thiomyristoyl
CAS:<p>Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.</p>Fórmula:C34H51N3O3SPureza:99.16%Forma y color:SolidPeso molecular:581.85Selisistat S-enantiomer
CAS:<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Fórmula:C13H13ClN2OPureza:99.86%Forma y color:SolidPeso molecular:248.71Suramin Sodium Salt
CAS:<p>Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.</p>Fórmula:C51H34N6Na6O23S6Pureza:97.47% - 99.97%Forma y color:WhitePeso molecular:1429.15CAY10602
CAS:<p>CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.</p>Fórmula:C22H15FN4O2SPureza:98.92%Forma y color:SolidPeso molecular:418.44Nicotinamide riboside chloride
CAS:<p>NR, also SRT647, is a B3 vitamin form; precursor to NAD+.</p>Fórmula:C11H15ClN2O5Pureza:98.92% - 99.86%Forma y color:SolidPeso molecular:290.7AK-1
CAS:<p>AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.</p>Fórmula:C19H21N3O5SPureza:98.32% - 99.44%Forma y color:SolidPeso molecular:403.45E1231
CAS:<p>E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.</p>Fórmula:C21H21N3O3Pureza:98.45%Forma y color:SolidPeso molecular:363.41YK-3-237
CAS:<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Fórmula:C19H21BO7Pureza:99.47%Forma y color:SolidPeso molecular:372.18Scopolin
CAS:<p>Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.</p>Fórmula:C16H18O9Pureza:98.97% - ≥95%Forma y color:SolidPeso molecular:354.31Agrimol B
CAS:<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Fórmula:C37H46O12Pureza:99.06% - ≥95%Forma y color:SolidPeso molecular:682.753-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Fórmula:C7H6N4Pureza:99.16% - >99.99%Forma y color:SolidPeso molecular:146.15Tenovin-1
CAS:<p>Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.</p>Fórmula:C20H23N3O2SPureza:99.33%Forma y color:SolidPeso molecular:369.48Dihydrocoumarin
CAS:<p>Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).</p>Fórmula:C9H8O2Pureza:98.46%Forma y color:Leaflets Room Temperature (Ntp 1992)Peso molecular:148.16Gardenia yellow
CAS:<p>Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.</p>Fórmula:C44H64O24Pureza:98.24% - 98.82%Forma y color:Orange Yellow To Reddish Yellow PowderPeso molecular:976.96Tenovin-6
CAS:<p>Tenovin-6 is a p53 transcriptional activity agonist.</p>Fórmula:C25H34N4O2SPureza:97.71% - >99.99%Forma y color:SolidPeso molecular:454.63Selisistat
CAS:<p>Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).</p>Fórmula:C13H13ClN2OPureza:98.53% - 99.94%Forma y color:SolidPeso molecular:248.71SRT1720 hydrochloride
CAS:<p>SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).</p>Fórmula:C25H24ClN7OSPureza:98% - 99.93%Forma y color:SolidPeso molecular:506.22SRT 1720 dihydrochloride
CAS:<p>SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).</p>Fórmula:C25H25Cl2N7OSPureza:98.58%Forma y color:SolidPeso molecular:542.48Ginkgolide C
CAS:<p>Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.</p>Fórmula:C20H24O11Pureza:99.71% - 99.98%Forma y color:White PowderPeso molecular:440.4SirReal2
CAS:<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Fórmula:C22H20N4OS2Pureza:98.96% - 99.75%Forma y color:SolidPeso molecular:420.55Ganoderic acid D
CAS:<p>Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.</p>Fórmula:C30H42O7Pureza:98.06% - 99.98%Forma y color:SolidPeso molecular:514.65AGK2
CAS:<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Fórmula:C23H13Cl2N3O2Pureza:98.68% - 99.17%Forma y color:SolidPeso molecular:434.27Salermide
CAS:<p>Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.</p>Fórmula:C26H22N2O2Pureza:97.09% - 99.55%Forma y color:SolidPeso molecular:394.47Inauhzin
CAS:<p>Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).</p>Fórmula:C25H19N5OS2Pureza:98% - 99.36%Forma y color:SolidPeso molecular:469.58UBCS039
CAS:<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Fórmula:C16H13N3Pureza:98.31%Forma y color:SolidPeso molecular:247.29SRT 1720
CAS:<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Fórmula:C25H23N7OSPureza:98.84%Forma y color:SolidPeso molecular:469.56Selisistat R-enantiomer
CAS:<p>Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).</p>Fórmula:C13H13ClN2OPureza:99.8%Forma y color:SolidPeso molecular:248.71
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