Receptor de andrógenos
El receptor de andrógenos (AR) es un receptor hormonal nuclear que se activa al unirse a andrógenos, como la testosterona y la dihidrotestosterona. Este receptor juega un papel crucial en el desarrollo y mantenimiento de las características masculinas, así como en la regulación de varios procesos fisiológicos, incluyendo el crecimiento muscular, la libido y la densidad ósea. Los inhibidores del receptor de andrógenos son ampliamente estudiados en el contexto del cáncer de próstata, donde la señalización del AR a menudo está sobreexpresada. En CymitQuimica, ofrecemos una gama de moduladores del receptor de andrógenos de alta calidad para apoyar su investigación en endocrinología, biología del cáncer y regulación hormonal.
Se han encontrado 230 productos de "Receptor de andrógenos"
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BMS-986365
CAS:BMS-986365 (CC-94676) is an orally available, selective and highly potent AR degrader with potential anticancer activity that inhibits AR signaling and suppresses tumor growth for the study of prostate cancer.Fórmula:C41H45F3N8O5SPureza:98.69% - 99.96%Forma y color:SoildPeso molecular:818.91ORM-15341
CAS:ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)Fórmula:C19H17ClN6O2Pureza:98.01%Forma y color:SolidPeso molecular:396.83Vosilasarm
CAS:RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.Fórmula:C20H16ClN5O2Pureza:99.01% - 99.6%Forma y color:A Crystalline SolidPeso molecular:393.82Topilutamide
CAS:Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.Fórmula:C13H11F6N3O5Pureza:98.77% - 99.24%Forma y color:SolidPeso molecular:403.23Ref: TM-T13184
1mg52,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg178,00€25mg371,00€50mg583,00€100mg830,00€200mg1.134,00€Nilutamide
CAS:Nilutamide, a nonsteroidal anti-androgen, treats prostate cancer by blocking androgen receptors, not affecting other hormone receptors.Fórmula:C12H10F3N3O4Pureza:98.67% - 99.78%Forma y color:Crystalline SolidPeso molecular:317.22Chlormadinone acetate
CAS:Chlormadinone acetate (Gestafortin) is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.Fórmula:C23H29ClO4Pureza:98.11% - 98.97%Forma y color:Crystals From Menthanol Or Ether Crystalline SolidPeso molecular:404.93Bicalutamide
CAS:Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting theFórmula:C18H14F4N2O4SPureza:98% - 99.87%Forma y color:Off-White Crystalline SolidPeso molecular:430.37Ligandrol
CAS:Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.Fórmula:C14H12F6N2OPureza:99.94% - >99.99%Forma y color:SolidPeso molecular:338.253,3'-Diindolylmethane
CAS:3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.Fórmula:C17H14N2Pureza:99.09%Forma y color:SolidPeso molecular:246.31Zanoterone
CAS:Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders andFórmula:C23H32N2O3SPureza:99.03% - 99.92%Forma y color:SoildPeso molecular:416.58Allylestrenol
CAS:Allylestrenol (Gestanin) is a synthetic steroid with progestational activity.Fórmula:C21H32OPureza:>99.99%Forma y color:White Crystalline PowderPeso molecular:300.48Luxdegalutamide
CAS:Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades theFórmula:C45H54FN7O6Pureza:99.95%Forma y color:SolidPeso molecular:807.95UT-155
CAS:UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).Fórmula:C20H15F4N3O2Pureza:98.94%Forma y color:SolidPeso molecular:405.35Ref: TM-T13272
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg167,00€25mg260,00€50mg356,00€100mg505,00€Flutamide
CAS:Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.Fórmula:C11H11F3N2O3Pureza:99.6% - 99.96%Forma y color:SolidPeso molecular:276.21UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFórmula:C15H12F4N4O2Pureza:98.12%Forma y color:SolidPeso molecular:356.27Ref: TM-T13273
1mg50,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg177,00€25mg334,00€50mg505,00€100mg782,00€Adrenocorticotropic hormone TFA
Adrenocorticotropic hormone TFA is an adrenocorticotropic hormone involved in neurohormonal regulation of the body.Pureza:99.71%Forma y color:Odour SolidN-Desmethyl-Apalutamide
CAS:N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.Fórmula:C20H13F4N5O2SPureza:98.6%Forma y color:SolidPeso molecular:463.41Ref: TM-T12146
1mg111,00€5mg245,00€1mL*10mM (DMSO)264,00€10mg354,00€25mg532,00€50mg735,00€100mg982,00€200mg1.333,00€Ostarine
CAS:Ostarine (MK-2866) is a non-steroidal SARM mimicking testosterone to boost muscle growth, libido, fertility, and may help prevent muscle wasting in cancer.Fórmula:C19H14F3N3O3Pureza:99.69% - 99.90%Forma y color:SolidPeso molecular:389.33AS-601811
CAS:AS-601811 is a bio-active chemical.Fórmula:C15H17NOPureza:98.05% - 99.58%Forma y color:SolidPeso molecular:227.3Adrenosterone
CAS:Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.Fórmula:C19H24O3Pureza:98.13% - 98.29%Forma y color:SolidPeso molecular:300.39Spironolactone
CAS:Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.Fórmula:C24H32O4SPureza:99.87%Forma y color:White PowderPeso molecular:416.57SK33
CAS:SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.Fórmula:C20H13F9N2O3Pureza:99.55%Forma y color:SolidPeso molecular:500.31Ref: TM-T12928
1mg34,00€5mg71,00€1mL*10mM (DMSO)90,00€10mg110,00€25mg212,00€50mg340,00€100mg550,00€200mg780,00€AR antagonist 1
CAS:AR antagonist 1 is a potent antagonist of the androgen receptor.Fórmula:C15H19ClN2OPureza:99.07%Forma y color:SolidPeso molecular:278.78Ref: TM-T10359
1mg57,00€1mL*10mM (DMSO)112,00€5mg118,00€10mg170,00€25mg279,00€50mg371,00€100mg522,00€200mg710,00€Andarine
CAS:Andarine (GTx-007) (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).Fórmula:C19H18F3N3O6Pureza:99.88%Forma y color:Pale Yellow SolidPeso molecular:441.36Cyproterone acetate
CAS:Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues andFórmula:C24H29ClO4Pureza:98.43% - 99.83%Forma y color:Crystals From Diisopropyl Ether OdourPeso molecular:416.94ACP-105
CAS:ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgenFórmula:C16H19ClN2OPureza:99.89%Forma y color:SolidPeso molecular:290.79Ref: TM-T14116
2mg38,00€5mg58,00€1mL*10mM (DMSO)65,00€10mg90,00€25mg164,00€50mg226,00€100mg325,00€200mg455,00€Medroxyprogesterone Acetate
CAS:Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. Farlutin is a long-acting contraceptive.Fórmula:C24H34O4Pureza:99.05% - 99.44%Forma y color:White PowderPeso molecular:386.522,2,5,7,8-Pentamethyl-6-Chromanol
CAS:2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation andFórmula:C14H20O2Pureza:98.72%Forma y color:SolidPeso molecular:220.31Proxalutamide
CAS:Proxalutamide is a potent antagonist of the androgen receptor (AR).Fórmula:C24H19F4N5O2SPureza:99.11%Forma y color:SolidPeso molecular:517.5Ref: TM-T15445
1mg79,00€5mg168,00€1mL*10mM (DMSO)192,00€10mg258,00€25mg508,00€50mg777,00€100mg1.132,00€200mg1.516,00€Octinoxate
CAS:Octinoxate (Octyl 4-methoxycinnamate) is an organic compound that is used is in sunscreens and other cosmetics to absorb UV-B rays from the sun.Fórmula:C18H26O3Pureza:99.93%Forma y color:Less To Pale Yellow Viscous Liquid (Ntp 1992) Physical Description Colorless To Pale Yellow Viscous Liquid (Ntp 1992)Peso molecular:290.40BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Fórmula:C42H46ClN5O7Forma y color:SolidPeso molecular:767.30858Nuclear Receptor Compound Library
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;Forma y color:Odour SolidRef: TM-L1510
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarARD-2585
CAS:ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Fórmula:C41H43ClN8O5Forma y color:SolidPeso molecular:763.28Tibolone
CAS:Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for theFórmula:C21H28O2Pureza:99.70% - 99.71%Forma y color:White To Off-White Crystalline PowderPeso molecular:312.45TD-802
CAS:TD-802, an AR-targeting PROTAC with microsomal stability, shows promise for castration-resistant prostate cancer.Fórmula:C52H61ClN10O6Forma y color:SolidPeso molecular:957.56K2-B4-5e
K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.Fórmula:C52H49ClN8O6SPeso molecular:948.31843Cl-4AS-1
CAS:steroidal androgen receptor agonistFórmula:C26H33ClN2O2Pureza:98%Forma y color:SolidPeso molecular:441.01Dipropyl phthalate
CAS:Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Fórmula:C14H18O4Pureza:98.62%Forma y color:SolidPeso molecular:250.29PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Fórmula:C43H49ClN6O5Forma y color:SolidPeso molecular:765.3399,10-Dihydrophenanthrene
CAS:9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.Fórmula:C14H12Pureza:98.76%Forma y color:SolidPeso molecular:180.25ODM-204
CAS:ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).Fórmula:C20H21F3N4Pureza:98%Forma y color:SolidPeso molecular:374.40Adrenocorticotropic hormone
CAS:ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.Forma y color:SolidLambertianic acid
CAS:Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Fórmula:C20H28O3Pureza:98%Forma y color:SolidPeso molecular:316.441ARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Fórmula:C62H74ClFN8O7SForma y color:SolidPeso molecular:1129.83Faznolutamide
CAS:Faznolutamide is an antiandrogen agent [1] [2] .Fórmula:C19H17FN4O2SForma y color:SolidPeso molecular:384.43PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.Fórmula:C45H68F3N3O11Forma y color:SolidPeso molecular:884.03Inocoterone acetate
CAS:Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.Fórmula:C18H26O3Forma y color:SolidPeso molecular:290.40Linuron
CAS:Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Fórmula:C9H10Cl2N2O2Pureza:99.08%Forma y color:White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicidePeso molecular:249.09LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Forma y color:Odour Solid3-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Forma y color:Odour Solid
