Receptor de andrógenos
El receptor de andrógenos (AR) es un receptor hormonal nuclear que se activa al unirse a andrógenos, como la testosterona y la dihidrotestosterona. Este receptor juega un papel crucial en el desarrollo y mantenimiento de las características masculinas, así como en la regulación de varios procesos fisiológicos, incluyendo el crecimiento muscular, la libido y la densidad ósea. Los inhibidores del receptor de andrógenos son ampliamente estudiados en el contexto del cáncer de próstata, donde la señalización del AR a menudo está sobreexpresada. En CymitQuimica, ofrecemos una gama de moduladores del receptor de andrógenos de alta calidad para apoyar su investigación en endocrinología, biología del cáncer y regulación hormonal.
Se han encontrado 229 productos de "Receptor de andrógenos"
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AR ligand-44
CAS:AR ligand-44 is an androgen receptor (androgen receptor) ligand that can be utilized in the synthesis of PROTACs such as [ARD-2051].Fórmula:C23H24ClN3O2Forma y color:SolidPeso molecular:409.91Androgen receptor antagonist 11
CAS:Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.Fórmula:C20H19F3N4O3SForma y color:SolidPeso molecular:452.45PROTAC Androgen receptor degrader-1
CAS:PROTACAndrogen receptor degrader-1 (Ex.14) is a PROTAC degrader targeting the androgen receptor, with a DC50 of 6 nM. This compound is applicable in prostate cancer research.Fórmula:C43H48ClN9O2Forma y color:SolidPeso molecular:758.35KF-19418
CAS:KF-19418 is a follicle stimulant that directly activates follicles in vitro and promotes hair growth in vivo.Fórmula:C21H14N4OForma y color:SolidPeso molecular:338.36Pentomone
CAS:Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Fórmula:C24H26O5Forma y color:SolidPeso molecular:394.46FL442
CAS:FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).Fórmula:C15H13F3N2OForma y color:SolidPeso molecular:294.27LX1
CAS:LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Fórmula:C22H15F6NO2Forma y color:SolidPeso molecular:439.35Androstatrione
CAS:<p>Androstatrione is an androgenic compound.</p>Fórmula:C19H26O3Forma y color:SolidPeso molecular:302.41PF-998425
CAS:non-steroidal androgen receptor (AR) antagonistFórmula:C14H14F3NOPureza:98%Forma y color:SolidPeso molecular:269.26
