NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 362 productos para "NF-κB".
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Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Forma y color:SolidPeso molecular:512.46TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Fórmula:C28H26N4O5Pureza:98%Forma y color:SolidPeso molecular:498.53DBMB
CAS:DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.Fórmula:C24H22N4OForma y color:SolidPeso molecular:382.458Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Fórmula:C22H20O12Forma y color:SolidPeso molecular:476.39K-14585
CAS:K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.Fórmula:C51H56Cl2N8O4Forma y color:SolidPeso molecular:915.95TLR4/NF-κB/MAPK-IN-1
CAS:TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.Fórmula:C19H25BrO6Forma y color:SolidPeso molecular:429.3oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Fórmula:C36H58O5Forma y color:SolidPeso molecular:570.84(Z)-11,12-Epoxyeicosatrienoic acid
CAS:(Z)-11,12-Epoxyeicosatrienoic acid is a potent renal microvascular dilator with anti-inflammatory properties. It inhibits leukocyte adhesion to the vascular wall by suppressing the NF-κB pathway and IκB kinase (IKK) activity. This compound is useful in studies related to vascular inflammation.Fórmula:C20H32O3Peso molecular:320.47GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Fórmula:C22H20O8Forma y color:SolidPeso molecular:412.39AS2690168 (free base)
CAS:AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Fórmula:C17H13F3N4OForma y color:SolidPeso molecular:346.306RIPK2-IN-6
CAS:RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Fórmula:C26H21NO3Forma y color:SolidPeso molecular:395.45AS2690168 hydrochloride
CAS:AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Fórmula:C17H15Cl2F3N4OForma y color:SolidPeso molecular:419.228NLRP3-IN-78
CAS:NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.Fórmula:C12H5Cl2N3O4S2Forma y color:SolidPeso molecular:390.222NF-κB-IN-6
NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signalingFórmula:C14H20N2O3Forma y color:SolidPeso molecular:264.32NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Fórmula:C20H22N4O3Forma y color:SolidPeso molecular:366.41MAY0132
CAS:MAY0132 is a selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 inhibits the replication of RSV, HMPV, and AdV, while reducing viral-induced cytokine production and NF-κB activation.Fórmula:C16H15ClF3NPureza:99.75%Forma y color:White SolidPeso molecular:313.75Ref: TM-T204630
1mg175,00€5mg434,00€1mL*10mM (DMSO)444,00€10mg620,00€25mg873,00€50mg1.215,00€100mg1.738,00€Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Fórmula:C23H17NO2Se2Forma y color:SolidPeso molecular:497.31Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Fórmula:C17H13N3O3Pureza:99.43% - 99.65%Forma y color:Yellow SolidPeso molecular:307.3HOIPIN-8 sodium
CAS:HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Fórmula:C23H15F2N4NaO3Pureza:99.99%Forma y color:SolidPeso molecular:456.38Ref: TM-T62826
1mg66,00€5mg145,00€1mL*10mM (DMSO)146,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€200mg973,00€UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Fórmula:C18H17N3OPureza:98.51%Forma y color:Yellow SolidPeso molecular:291.35Ref: TM-T88314
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg80,00€25mg145,00€50mg222,00€100mg340,00€200mg504,00€
