NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 385 productos de "NF-κB"
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BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Fórmula:C10H7NO3Pureza:96.48% - 97%Forma y color:Yellow Crystalline PowderPeso molecular:189.17IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFórmula:C35H33N5O2Pureza:98%Forma y color:SolidPeso molecular:555.67TNF-α-IN-18
CAS:TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.Fórmula:C16H7ClF2O4Pureza:99.77%Forma y color:SolidPeso molecular:336.67Anti-inflammatory agent 21
CAS:Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.Fórmula:C24H21FO6Forma y color:SolidPeso molecular:424.42HSR1304
CAS:HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.Fórmula:C24H21ClN2O3Forma y color:SolidPeso molecular:420.89Asperbisabolane L
Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.Fórmula:C12H14O3Forma y color:SolidPeso molecular:206.24IKKβ-IN-1
CAS:IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Fórmula:C31H30N4O4SForma y color:SolidPeso molecular:554.66Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H26ClN3O4Forma y color:SolidPeso molecular:431.91NF-κB-IN-2
CAS:NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.Fórmula:C15H18O3Forma y color:SolidPeso molecular:246.3XT2
CAS:XT2 is a potent, oral NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 9.1 nM, reduces ALT levels, and curbs immune cell liver infiltration.Fórmula:C19H14FN5OSForma y color:SolidPeso molecular:379.41IMD-ferulic
IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.Fórmula:C36H41N7O4Forma y color:SolidPeso molecular:635.76NF-κB-IN-8
CAS:NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.Fórmula:C24H21N3O3Pureza:98%Forma y color:SolidPeso molecular:399.44CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Fórmula:C22H21N3O6S2Forma y color:SolidPeso molecular:487.55Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Fórmula:C23H17N3OS3Pureza:98.02% - 98.04%Forma y color:SolidPeso molecular:447.6DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Fórmula:C19H17FN8Forma y color:SolidPeso molecular:376.39Sul-121 HCl
CAS:Sul-121 HCl combats COPD by reducing inflammation and AHR via oxidative stress inhibition.Fórmula:C18H27ClN2O3Pureza:98%Forma y color:SolidPeso molecular:354.87IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Fórmula:C22H25F3N4O3Pureza:98.09%Forma y color:SolidPeso molecular:450.45Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).
Fórmula:C19H18N3O2PSPureza:99.41%Forma y color:SolidPeso molecular:383.4Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.
Fórmula:C20H21F3N4O4SPureza:98.54%Forma y color:SolidPeso molecular:470.47NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Fórmula:C13H8F2INO2Pureza:99.98%Forma y color:SolidPeso molecular:375.11
