NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Se han encontrado 385 productos de "NF-κB"
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Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Fórmula:C18H19F3N2O2SePeso molecular:432.05638HS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
Fórmula:C17H16N4O3Pureza:98.62%Forma y color:SolidPeso molecular:324.33NF-κB Signaling Compound Library
A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;Forma y color:Odour SolidRef: TM-L3800
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarBIZ 114
CAS:BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.Fórmula:C24H40O3Forma y color:SolidPeso molecular:376.57Hesperidin methylchalcone
CAS:Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Fórmula:C29H36O15Pureza:99.53%Forma y color:Yellow PowderPeso molecular:624.59DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Forma y color:SolidPeso molecular:525.6Anti-RANKL Antibody (4B810)
Anti-RANKL Antibody (4B810) is a Rabbit IgG monoclonal antibody targeting Human RANKL.Forma y color:Odour LiquidRS 09
CAS:TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.Fórmula:C31H49N9O9Pureza:98%Forma y color:SolidPeso molecular:691.78ML 120B dihydrochloride
CAS:MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Fórmula:C19H17Cl3N4O2Forma y color:SolidPeso molecular:439.72SEMBL
CAS:SEMBL, a novel inhibitor of DNA binding of NF-kappaB component p65 in vitro, inhibits NF-kappaB and cellular invasion in ovarian carcinoma ES-2 cells.Fórmula:C12H11NO4Pureza:98%Forma y color:SolidPeso molecular:233.22CBL0137 hydrochloride
CAS:CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB.Cost-effective and quality-assured.Fórmula:C21H25ClN2O2Pureza:99.35% - 99.86%Forma y color:SolidPeso molecular:372.88Ginsenoside Rg1
CAS:Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng).Fórmula:C42H72O14Pureza:99% - 99.92%Forma y color:White Crystalline PowderPeso molecular:801.01Myrcene
CAS:Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.Fórmula:C10H16Pureza:98%Forma y color:Colourless Slightly Amber Coloured LiquidPeso molecular:136.23Stachydrine Hydrochloride
CAS:Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.Fórmula:C7H14ClNO2Pureza:99.53% - 99.71%Forma y color:Light Yellow PastePeso molecular:179.64Dehydrodiisoeugenol
CAS:Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Fórmula:C20H22O4Pureza:99.97%Forma y color:SolidPeso molecular:326.39Berbamine dihydrochloride
CAS:Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Fórmula:C37H42Cl2N2O6Pureza:95% - 99.99%Forma y color:SolidPeso molecular:681.65NF-κB-IN-1
CAS:NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathwayFórmula:C31H30O8Pureza:99.03%Forma y color:SolidPeso molecular:530.57Ref: TM-T9105
1mg166,00€5mg341,00€1mL*10mM (DMSO)398,00€10mg550,00€25mg898,00€50mg1.216,00€100mg1.644,00€Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Fórmula:C42H72O14Pureza:99.42% - 99.65%Forma y color:SolidPeso molecular:801.01Ginsenoside Rg2
CAS:Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.Fórmula:C42H72O13Pureza:99.77% - 99.78%Forma y color:SolidPeso molecular:785.01Ref: TM-T2873
2mg37,00€5mg52,00€1mL*10mM (DMSO)87,00€10mg88,00€25mg131,00€50mg188,00€100mg279,00€500mg658,00€2-Hydroxychalcone
CAS:2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated. It inhibits invasion of breast cancer cells.Fórmula:C15H12O2Pureza:99.6%Forma y color:SolidPeso molecular:224.25
