IκB / IKK
El complejo IκB/IKK es un regulador clave de la vía de señalización NF-κB, que controla la expresión de genes involucrados en las respuestas inmunitarias, la inflamación y la supervivencia celular. Las proteínas IκB inhiben la actividad de NF-κB al secuestrarlo en el citoplasma, mientras que las IKKs fosforilan a IκB, lo que conduce a su degradación y a la activación de NF-κB. La desregulación de la vía IκB/IKK está relacionada con la inflamación crónica, el cáncer y las enfermedades autoinmunes. En CymitQuimica, ofrecemos una selección de moduladores de IκB/IKK de alta calidad para apoyar su investigación en transducción de señales, inflamación y desarrollo terapéutico.
Se han encontrado 61 productos de "IκB / IKK"
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IMD-0560
CAS:<p>IMD-0560 is a novel inhibitor of IκB kinase β.</p>Fórmula:C15H8BrF6NO2Pureza:99.51%Forma y color:SolidPeso molecular:428.12Ac2-26 ammonium
<p>Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.</p>Fórmula:C141H210N32O44S·xNH3Pureza:95.58%Forma y color:SolidPeso molecular:3089.43 (free base)TBK1/IKKε-IN-2
CAS:<p>TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.</p>Fórmula:C26H27N5O3Pureza:98.89%Forma y color:SolidPeso molecular:457.52BAY-985
CAS:<p>BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.</p>Fórmula:C27H30F3N9OPureza:99.62%Forma y color:SolidPeso molecular:553.58Vinpocetine
CAS:<p>Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).</p>Fórmula:C22H26N2O2Pureza:99.85% - 99.98%Forma y color:White Crystalline SolidPeso molecular:350.45MRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Fórmula:C26H36N6O2Pureza:99.25% - 99.84%Forma y color:SolidPeso molecular:464.6Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Fórmula:C20H28O6Forma y color:SolidPeso molecular:364.43Verproside
CAS:<p>Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.</p>Fórmula:C22H26O13Forma y color:SolidPeso molecular:498.437TBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Fórmula:C31H36F2N8O4Forma y color:SolidPeso molecular:622.678IKK-IN-3
CAS:<p>IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).</p>Fórmula:C17H17N5SForma y color:SolidPeso molecular:323.42HOIPIN-1
CAS:<p>HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-</p>Fórmula:C17H13NaO4Pureza:98.83%Forma y color:SoildPeso molecular:304.27LY2409881
CAS:<p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>Fórmula:C24H29ClN6OSForma y color:SolidPeso molecular:485.05PS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Fórmula:C17H13Cl3N4OPureza:98%Forma y color:SolidPeso molecular:395.67SU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Forma y color:Odour SolidPROTAC STING degrader-4
<p>PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).</p>Fórmula:C39H42Cl2N8O9Forma y color:SolidPeso molecular:836.24518ML 120B dihydrochloride
CAS:<p>MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.</p>Fórmula:C19H17Cl3N4O2Forma y color:SolidPeso molecular:439.72IKK 16 hydrochloride
CAS:<p>IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.</p>Fórmula:C28H30ClN5OSForma y color:SolidPeso molecular:520.09GSK8612
CAS:<p>GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .</p>Fórmula:C17H17BrF3N7O2SPureza:99.46% - 99.8%Forma y color:SolidPeso molecular:520.33AZD3264
CAS:<p>AZD3264 is a new type IKK2 inhibitor.</p>Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Forma y color:SolidPeso molecular:441.5MLN120B
CAS:<p>MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).</p>Fórmula:C19H15ClN4O2Pureza:98.92%Forma y color:SolidPeso molecular:366.8
