IκB / IKK
El complejo IκB/IKK es un regulador clave de la vía de señalización NF-κB, que controla la expresión de genes involucrados en las respuestas inmunitarias, la inflamación y la supervivencia celular. Las proteínas IκB inhiben la actividad de NF-κB al secuestrarlo en el citoplasma, mientras que las IKKs fosforilan a IκB, lo que conduce a su degradación y a la activación de NF-κB. La desregulación de la vía IκB/IKK está relacionada con la inflamación crónica, el cáncer y las enfermedades autoinmunes. En CymitQuimica, ofrecemos una selección de moduladores de IκB/IKK de alta calidad para apoyar su investigación en transducción de señales, inflamación y desarrollo terapéutico.
Se han encontrado 61 productos de "IκB / IKK"
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DMX-129
CAS:<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Fórmula:C19H17FN8Forma y color:SolidPeso molecular:376.39IKK2-IN-4
CAS:<p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>Fórmula:C12H11N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:261.31-Dehydro-[10]-gingerdione
CAS:<p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>Fórmula:C21H30O4Forma y color:SolidPeso molecular:346.46HPN-01
CAS:<p>HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.</p>Fórmula:C19H16ClN3O3SPureza:98.07% - 98.17%Forma y color:SolidPeso molecular:401.87CAY10575
CAS:<p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>Fórmula:C22H21N3O6S2Forma y color:SolidPeso molecular:487.55Bay 65-1942 hydrochloride
CAS:<p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>Fórmula:C22H26ClN3O4Forma y color:SolidPeso molecular:431.91GSK319347A
CAS:<p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>Fórmula:C22H19N3O5S2Pureza:98.42%Forma y color:SolidPeso molecular:469.53CGA-JK3
CAS:<p>CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.</p>Fórmula:C15H19NO3Pureza:98%Forma y color:SolidPeso molecular:261.32IKK-IN-1
CAS:<p>IKK-IN-1 is an inhibitor of IKK.</p>Fórmula:C22H26ClN3O4Pureza:98%Forma y color:SolidPeso molecular:431.91PF 184
CAS:<p>IKKβ inhibitor</p>Fórmula:C32H32ClFN6O4Pureza:98%Forma y color:SolidPeso molecular:619.09(Rac)-BAY-985
CAS:<p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>Fórmula:C27H30F3N9OPureza:98%Forma y color:SolidPeso molecular:553.58Bay 65-1942 (R form)
CAS:<p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>Fórmula:C22H25N3O4Pureza:98%Forma y color:SolidPeso molecular:395.45ACHP Hydrochloride
CAS:<p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>Fórmula:C21H25ClN4O2Pureza:99.83%Forma y color:SolidPeso molecular:400.9IKK-IN-4
CAS:<p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>Fórmula:C18H19N5SForma y color:SolidPeso molecular:337.44TBK1-IN-1
CAS:<p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>Fórmula:C27H37N7O2Pureza:>99.99%Forma y color:SolidPeso molecular:491.63PF-184
<p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.</p>Fórmula:C32H32ClFN6O4Forma y color:SolidPeso molecular:619.09Glabrescone C
CAS:<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Fórmula:C19H22O7Forma y color:SolidPeso molecular:362.37Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Fórmula:C22H20O12Forma y color:SolidPeso molecular:476.39TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Fórmula:C28H26N4O5Pureza:98%Forma y color:SolidPeso molecular:498.53GTCpFE
CAS:<p>GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.</p>Fórmula:C22H20O8Forma y color:SolidPeso molecular:412.39
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