Nrf2

AA147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm …

NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.

(E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 …

Methyl protocatechuate is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and …

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum …

Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II …

Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, …

CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory …

Mangiferin is used for antidiabetes. Extracted from Mangifera indica L.

Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in …

Pyridoxine hydrochloride is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which …

Luteolin is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components …

Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means …

Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be …

Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the …

Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of …

Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through …

Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also …

Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.

3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adjuvant …

Rehmapicrogenin regulates the Nrf2/ARE signaling pathway. Nrf2/ARE signaling pathway is the most important pathway of …

Rupestonic acid is a compound in Artemisia rupestris L., a well-known traditional Uighur medicine for …

TAT 14, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT-14 increases Nrf2 …

DDO-7263 is a potent Nrf2-ARE activator. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits …

Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative …

Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in …

Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is …

Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated …

(R)-Sulforaphane is a potent inducer of the Keap1/Nrf2/ARE pathway.

Ginsenoside Rh3 is a natural product extracted from Panax ginseng C. A. Mey. Ginsenoside Rh3 …

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.

Daidzin 6''-O-malonate may have anticancer activity.

Procyanidin B4 reveals significant antioxidant activity

Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to …

4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

CDDO-EA is an activator of the Nrf2/antioxidant response element.

Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.

Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and …

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C …

Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts …

Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal …

Dimethyl fumarate, a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.

Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells …

TAT 14 acetate, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT 14 …

β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism …

Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in …

Notoginsenoside R2 has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 …

Tert-butylhydroquinone (tBHQ) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor …

Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the …

Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H …

Artemisitene is the oxidized form of Artemisinin and is an antimalarial agent. Artemisinin precursors are …

CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide …

ML385 is a new-type and selective NRF2 inhibitor.

(-)-Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative …

Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown …

AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly …

Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.

Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 …

4-Octyl Itaconate is a cell-permeable Itaconate derivative and an anti-inflammatory metabolite. Itaconate activates Nrf2 via …

4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer

Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is …

1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute …

Danshensu is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.

ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell …

1. Corynoline is an acetylcholinesterase inhibitor.

2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with …

Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits …

Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially …