Nrf2
Nrf2 es un factor de transcripción que regula la expresión de proteínas antioxidantes y enzimas de desintoxicación, desempeñando un papel crucial en la defensa celular contra el estrés oxidativo y la inflamación. La activación de la señalización de Nrf2 proporciona protección contra diversas enfermedades, incluyendo el cáncer, la neurodegeneración y los trastornos cardiovasculares. Los moduladores de Nrf2 están siendo explorados por su potencial en aplicaciones terapéuticas para reducir el daño oxidativo y la inflamación. En CymitQuimica, ofrecemos una gama de moduladores de la vía Nrf2 de alta calidad para apoyar su investigación en estrés oxidativo, inflamación y prevención de enfermedades.
Se han encontrado 81 productos de "Nrf2"
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4-Octyl itaconate
CAS:4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite.Fórmula:C13H22O4Pureza:99.3% - 99.94%Forma y color:SolidPeso molecular:242.31AT 14 acetate
TAT 14 acetate, a 14-mer peptide, activates Nrf2, has anti-inflammatory effects, and targets Keap1 without altering Nrf2 mRNA.Fórmula:C139H234N48O41Pureza:96.9%Forma y color:SolidPeso molecular:3233.64AEM1
CAS:AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.Fórmula:C20H14FN3O2SPureza:98.37% - 99.88%Forma y color:SolidPeso molecular:379.41Ref: TM-T8979
2mg38,00€5mg51,00€1mL*10mM (DMSO)60,00€10mg92,00€25mg170,00€50mg298,00€100mg510,00€200mg737,00€ML162
CAS:ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.Fórmula:C23H22Cl2N2O3SPureza:98.42% - 99.55%Forma y color:SolidPeso molecular:477.4Ref: TM-T8970
1mg43,00€5mg85,00€1mL*10mM (DMSO)92,00€10mg110,00€25mg215,00€50mg334,00€100mg467,00€200mg672,00€Brusatol
CAS:Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.Fórmula:C26H32O11Pureza:99.35% - 99.95%Forma y color:SolidPeso molecular:520.53Ref: TM-TQ0211
1mg37,00€5mg88,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg295,00€50mg477,00€100mg677,00€200mg888,00€Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFórmula:C21H24O10Pureza:97.16%Forma y color:SolidPeso molecular:436.41Ref: TM-T2S0731
1mg50,00€5mg99,00€1mL*10mM (DMSO)109,00€10mg141,00€25mg260,00€50mg385,00€100mg557,00€200mg790,00€Diroximel fumarate
CAS:Diroximel fumarate (Diroximel Fumarete), a prodrug of monomethyl fumarate in a controlled-release formulation, rapidly and potently converts to MMF in the body.Fórmula:C11H13NO6Pureza:99.8% - 99.88%Forma y color:SolidPeso molecular:255.22Ref: TM-T4271
2mg35,00€5mg55,00€1mL*10mM (DMSO)55,00€10mg80,00€25mg126,00€50mg187,00€100mg301,00€200mg425,00€CBR-470-1
CAS:CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.Fórmula:C14H20ClNO4S2Pureza:98.87%Forma y color:SolidPeso molecular:365.9AI-3
CAS:Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFórmula:C11H13ClO3S2Pureza:98%Forma y color:SolidPeso molecular:292.8Nrf2-Activator-12G
CAS:Nrf2-Activator-12G is a potent Nrf-2 activator.Fórmula:C15H13ClO3SPureza:99.92%Forma y color:SolidPeso molecular:308.78Nrf2 activator-5
CAS:Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.Fórmula:C25H30Cl2O6Forma y color:SolidPeso molecular:497.41Keap1-Nrf2-IN-12
CAS:eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.Fórmula:C26H28N2O10S2Forma y color:SolidPeso molecular:592.64NXPZ-2
CAS:NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.Fórmula:C27H27N5O7S2Forma y color:SolidPeso molecular:597.66MIND4-17
CAS:MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.Fórmula:C20H15N5O3SForma y color:SolidPeso molecular:405.43SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Forma y color:SolidPeso molecular:317.38Stigmane B
Stigmane B activates Nrf2, decreases apoptosis and ROS, boosts antioxidants, and is neuroprotective.Fórmula:C21H30O4Forma y color:SolidPeso molecular:346.46Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Fórmula:C8H16O2S2Pureza:97.51%Forma y color:Yellow To Orange LiquidPeso molecular:208.34(+)-DHMEQ
CAS:(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.Fórmula:C13H11NO5Forma y color:SolidPeso molecular:261.23BPK-29
CAS:BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.Fórmula:C26H32ClN3O3Pureza:98%Forma y color:SolidPeso molecular:470MSU38225
CAS:MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.Fórmula:C21H19N3Forma y color:SolidPeso molecular:313.4
