Nrf2
Nrf2 es un factor de transcripción que regula la expresión de proteínas antioxidantes y enzimas de desintoxicación, desempeñando un papel crucial en la defensa celular contra el estrés oxidativo y la inflamación. La activación de la señalización de Nrf2 proporciona protección contra diversas enfermedades, incluyendo el cáncer, la neurodegeneración y los trastornos cardiovasculares. Los moduladores de Nrf2 están siendo explorados por su potencial en aplicaciones terapéuticas para reducir el daño oxidativo y la inflamación. En CymitQuimica, ofrecemos una gama de moduladores de la vía Nrf2 de alta calidad para apoyar su investigación en estrés oxidativo, inflamación y prevención de enfermedades.
Se han encontrado 81 productos de "Nrf2"
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WN1316
CAS:WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Fórmula:C20H26Cl3N5OForma y color:SolidPeso molecular:458.81Nrf2 activator-4
CAS:Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.Fórmula:C23H24ClF3N2O3Pureza:98.53%Forma y color:SolidPeso molecular:468.9K67
CAS:K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Fórmula:C29H30N2O7S2Pureza:98.43%Forma y color:SolidPeso molecular:582.69Keap1-Nrf2-IN-14
CAS:Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.Fórmula:C30H29NO8SForma y color:SolidPeso molecular:563.62Keap1-Nrf2-IN-13
CAS:Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.Fórmula:C28H32N2O10S2Forma y color:SolidPeso molecular:620.69CDDO-EA
CAS:CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.Fórmula:C33H46N2O3Pureza:99.66%Forma y color:SolidPeso molecular:518.73Ref: TM-T10733
1mg80,00€5mg160,00€1mL*10mM (DMSO)177,00€10mg281,00€25mg485,00€50mg693,00€100mg893,00€200mg1.198,00€DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Fórmula:C14H9F2N3OPureza:99.85%Forma y color:SolidPeso molecular:273.24Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFórmula:C39H35N3O12S2Forma y color:SolidPeso molecular:801.84WRR139
CAS:WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1Fórmula:C25H32N2O4SForma y color:SolidPeso molecular:456.6Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Fórmula:C21H22ClN3O2Pureza:95.00% - 99.68%Forma y color:SolidPeso molecular:383.87Ref: TM-T12253
1mg71,00€2mg92,00€5mg152,00€10mg207,00€1mL*10mM (DMSO)285,00€25mg344,00€50mg485,00€100mg690,00€200mg888,00€Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Fórmula:C35H32N2O11S2Forma y color:SolidPeso molecular:720.77Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Fórmula:C73H114N16O26Forma y color:SolidPeso molecular:1631.78Keap1-Nrf2-IN-6
Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nMFórmula:C30H34N4O8SForma y color:SolidPeso molecular:610.68Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Fórmula:C22H26N4O4SPureza:98.07%Forma y color:SolidPeso molecular:442.53Ref: TM-T78841
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg197,00€25mg371,00€50mg512,00€100mg707,00€200mg1.018,00€Nrf2 activator-6
CAS:Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).Fórmula:C31H37ClFN5O5Forma y color:SolidPeso molecular:614.11Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Fórmula:C23H30N4O6SForma y color:SolidPeso molecular:490.57CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Fórmula:C6H6S3Forma y color:SolidPeso molecular:174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Fórmula:C20H17BrO3Forma y color:SolidPeso molecular:385.25VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Fórmula:C17H17ClN4O2Pureza:99.01% - 99.92%Forma y color:SolidPeso molecular:344.8KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Fórmula:C28H30N4O6SPureza:99.74%Forma y color:SolidPeso molecular:550.63Ref: TM-T11758L
1mg137,00€5mg281,00€1mL*10mM (DMSO)341,00€10mg423,00€25mg707,00€50mg1.018,00€100mg1.468,00€200mg1.963,00€
