Señalización JAK / STAT
Los inhibidores de la señalización JAK/STAT son compuestos que interrumpen la vía de la cinasa Janus (JAK) y del transductor y activador de la transcripción (STAT), la cual está involucrada en la señalización de citoquinas, el crecimiento celular y la respuesta inmunitaria. Estos inhibidores son herramientas importantes para estudiar la regulación de esta vía y su papel en diversas enfermedades, como el cáncer, los trastornos inmunitarios y las condiciones inflamatorias. Los inhibidores de JAK/STAT también están siendo desarrollados como terapias dirigidas para estas enfermedades. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de la señalización JAK/STAT para apoyar su investigación en biología molecular, oncología e inmunología.
Subcategorías de "Señalización JAK / STAT"
Se han encontrado 372 productos para "Señalización JAK / STAT".
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Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.Fórmula:C17H20N8O2SPureza:99.93%Forma y color:SoildPeso molecular:400.46Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Fórmula:C14H17N3O3Pureza:99.92%Forma y color:SolidPeso molecular:275.3Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.79%Forma y color:SolidPeso molecular:611.51Bromisoval
CAS:Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.Fórmula:C6H11BrN2O2Pureza:98.86%Forma y color:SolidPeso molecular:223.07Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Fórmula:C12H9N3O5Pureza:99.79% - 99.95%Forma y color:Yellow SolidPeso molecular:275.22Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Fórmula:C25H26F2N6O2Pureza:99.58%Forma y color:Yellow SolidPeso molecular:480.51Ref: TM-T67907
1mg90,00€2mg132,00€5mg215,00€10mg334,00€25mg620,00€50mg888,00€100mg1.378,00€500mg2.673,00€KT-333
CAS:KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Fórmula:C60H74ClN10O14PSPureza:98.12%Forma y color:White SolidPeso molecular:1257.78N-(3-Aminopropyl)cyclohexylamine
CAS:N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Fórmula:C9H20N2Pureza:98.05% - 98.82%Forma y color:SolidPeso molecular:156.2685Ilginatinib
CAS:Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H20FN7Pureza:98.4% - 99.01%Forma y color:SolidPeso molecular:389.43Ref: TM-T12266
1mg60,00€1mL*10mM (DMSO)126,00€5mg131,00€10mg177,00€25mg259,00€50mg371,00€100mg532,00€200mg705,00€Ilginatinib maleate
CAS:Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C25H24FN7O4Pureza:99.74% - 99.82%Forma y color:SolidPeso molecular:505.5Ref: TM-T12266L
1mg46,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg128,00€25mg180,00€50mg260,00€100mg371,00€200mg494,00€JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Fórmula:C23H24N2OPureza:98.36% - 99.15%Forma y color:SolidPeso molecular:344.45Ref: TM-T3042
2mg37,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg80,00€25mg148,00€50mg259,00€100mg477,00€500mg1.063,00€STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.Fórmula:C22H14N4O3Pureza:99.61%Forma y color:SolidPeso molecular:382.37Ref: TM-T60160
500mgA consultar5mg60,00€1mL*10mM (DMSO)60,00€10mg96,00€25mg168,00€50mg268,00€100mg404,00€Niclosamide
CAS:Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.Fórmula:C13H8Cl2N2O4Pureza:98.47% - 99.1%Forma y color:Yellow SolidPeso molecular:327.12Brepocitinib P-Tosylate
CAS:Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Fórmula:C25H29F2N7O4SPureza:99.82% - 99.97%Forma y color:SolidPeso molecular:561.6Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Fórmula:C24H28N8O2Pureza:98.06% - 99.94%Forma y color:SolidPeso molecular:460.53Ref: TM-T14331
1mg39,00€5mg84,00€1mL*10mM (DMSO)110,00€10mg116,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€Delgocitinib
CAS:Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Fórmula:C16H18N6OPureza:99.95%Forma y color:White SolidPeso molecular:310.35Ref: TM-T15096
1mg160,00€5mg295,00€1mL*10mM (DMSO)330,00€10mg462,00€25mg879,00€50mg1.341,00€100mg1.953,00€200mg2.628,00€Golidocitinib
CAS:Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Fórmula:C25H31N9O2Pureza:98.87% - 99.88%Forma y color:Yellow SolidPeso molecular:489.57WDR5-IN-6
CAS:WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Fórmula:C13H8Cl2N2O2SPureza:99.69%Forma y color:SoildPeso molecular:327.19Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H21ClFN7Pureza:99.55%Forma y color:SolidPeso molecular:425.89Ref: TM-T12266L2
1mg70,00€5mg150,00€1mL*10mM (DMSO)166,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg973,00€FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Forma y color:LiquidRef: TM-L1610
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultar
