Pim
Las quinasas Pim son una familia de quinasas serina/treonina que juegan un papel clave en la supervivencia celular, la proliferación y la apoptosis. Estas quinasas son efectores aguas abajo en la vía de señalización JAK/STAT y están involucradas en varios procesos fisiológicos, incluidas las respuestas inmunitarias y la hematopoyesis. La sobreexpresión de las quinasas Pim se ha asociado con el desarrollo de cáncer, lo que las convierte en objetivos importantes para la intervención terapéutica. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de quinasas Pim de alta calidad para apoyar su investigación en oncología, biología celular y transducción de señales.
Se han encontrado 33 productos para "Pim".
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Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.79%Forma y color:SolidPeso molecular:611.51Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Fórmula:C14H17N3O3Pureza:99.92%Forma y color:SolidPeso molecular:275.3Pim-1 kinase-IN-15
Pim-1 kinase-IN-15 (Compound 15) is a highly potent and selective inhibitor of Pim-1 kinase, with an IC50 value of 0.212 μM. This compound is capable of inducing apoptosis in tumor cells and inhibiting cell migration, making it a promising candidate for oncology research, including breast cancer studies.Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.Forma y color:Odour SolidR8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Fórmula:C111H211N59O26SPureza:98%Forma y color:SolidPeso molecular:2820.33VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Fórmula:C27H27N3O3Forma y color:SolidPeso molecular:441.522Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Fórmula:C11H9NO3SPureza:99.78%Forma y color:SolidPeso molecular:235.26TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Fórmula:C11H6F3NO2SPureza:98.82% - 99.89%Forma y color:White SolidPeso molecular:273.23SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Fórmula:C13H13NO3SPureza:99.99%Forma y color:White SolidPeso molecular:263.31Ref: TM-T3989
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)87,00€10mg93,00€25mg152,00€50mg222,00€100mg334,00€TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Fórmula:C18H11BrN2O2Pureza:97% - 97.98%Forma y color:SolidPeso molecular:367.2Ref: TM-T2253
1mg34,00€5mg60,00€1mL*10mM (DMSO)92,00€10mg94,00€25mg177,00€50mg269,00€100mg401,00€200mg580,00€SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Fórmula:C20H22F3N5OPureza:99.3% - >99.99%Forma y color:SolidPeso molecular:405.42Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Fórmula:C20H13N5OPureza:97.03% - 98.69%Forma y color:White SolidPeso molecular:339.35Ref: TM-T5093
1mg85,00€2mg124,00€5mg173,00€1mL*10mM (DMSO)192,00€10mg263,00€25mg464,00€50mg672,00€100mg945,00€TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Fórmula:C22H25F3N4OPureza:99.8% - 99.95%Forma y color:SolidPeso molecular:418.46HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Fórmula:C14H11NO2Pureza:98.92%Forma y color:SolidPeso molecular:225.24Ref: TM-T9583
1mg34,00€1mL*10mM (DMSO)73,00€5mg75,00€10mg110,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Forma y color:Yellow SolidPeso molecular:379.48Ref: TM-T2300
2mg35,00€5mg49,00€1mL*10mM (DMSO)54,00€10mg71,00€25mg112,00€50mg202,00€100mg358,00€200mg470,00€500mg750,00€Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Fórmula:C15H10O8Pureza:99.65% - 99.91%Forma y color:SolidPeso molecular:318.24Ref: TM-T8114
1mg94,00€5mg192,00€1mL*10mM (DMSO)202,00€10mg286,00€25mg482,00€50mg695,00€100mg945,00€500mg1.882,00€Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Fórmula:C16H12O6Pureza:98.53% - 99.87%Forma y color:SolidPeso molecular:300.26(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Fórmula:C11H6F3NO2SPureza:97.66% - 99.93%Forma y color:White SolidPeso molecular:273.23CX-6258 hydrochloride
CAS:CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Fórmula:C26H24ClN3O3·HClPureza:96.03% - 98.60%Forma y color:SolidPeso molecular:498.4Ref: TM-T6148
1mg40,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg120,00€25mg222,00€50mg356,00€100mg537,00€200mg762,00€K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Fórmula:C18H18N4OPureza:98.16%Forma y color:Yellow SolidPeso molecular:306.36
