Señalización JAK / STAT

Los inhibidores de la señalización JAK/STAT son compuestos que interrumpen la vía de la cinasa Janus (JAK) y del transductor y activador de la transcripción (STAT), la cual está involucrada en la señalización de citoquinas, el crecimiento celular y la respuesta inmunitaria. Estos inhibidores son herramientas importantes para estudiar la regulación de esta vía y su papel en diversas enfermedades, como el cáncer, los trastornos inmunitarios y las condiciones inflamatorias. Los inhibidores de JAK/STAT también están siendo desarrollados como terapias dirigidas para estas enfermedades. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de la señalización JAK/STAT para apoyar su investigación en biología molecular, oncología e inmunología.

Subcategorías de "Señalización JAK / STAT"

Se han encontrado 324 productos de "Señalización JAK / STAT"

Pureza (%)

100

productos por página.

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5,15-DPP
CAS:
- 22112-89-6
5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC 50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively [1].
Fórmula:C₃₂H₂₂N₄
Forma y color:Solid
Peso molecular:462.54
Ref: TM-T21501
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Ifidancitinib
CAS:
- 1236667-40-5
Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.
Fórmula:C₂₀H₁₈FN₅O₃
Pureza:98.05%
Forma y color:Solid
Peso molecular:395.39
Ref: TM-T38623
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FLLL32
CAS:
- 1226895-15-3
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
Fórmula:C₂₈H₃₂O₆
Pureza:97% - 97.90%
Forma y color:Solid
Peso molecular:464.55
Ref: TM-T6838
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Filgotinib
CAS:
- 1206161-97-8
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
Fórmula:C₂₁H₂₃N₅O₃S
Pureza:98.03% - ≥95%
Forma y color:Solid
Peso molecular:425.5
Ref: TM-T1929
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RGB-286638 free base
CAS:
- 784210-88-4
RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.
Fórmula:C₂₉H₃₅N₇O₄
Pureza:98% - 99.91%
Forma y color:Solid
Peso molecular:545.63
Ref: TM-T2378
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ZM39923 hydrochloride
CAS:
- 1021868-92-7
ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.
Fórmula:C₂₃H₂₅NO·HCl
Pureza:98.05%
Forma y color:Solid
Peso molecular:367.91
Ref: TM-T6145
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SHR0302
CAS:
- 1445987-21-2
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,
Fórmula:C₁₈H₂₂N₈O₂S
Pureza:99.11%
Forma y color:Solid
Peso molecular:414.48
Ref: TM-T9195
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Ritlecitinib
CAS:
- 1792180-81-4
Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.
Fórmula:C₁₅H₁₉N₅O
Pureza:98.82% - 99.92%
Forma y color:Solid
Peso molecular:285.34
Ref: TM-T5382
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JAK3-IN-6
CAS:
- 1443235-95-7
JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM
Fórmula:C₁₉H₁₈N₄O₃
Pureza:99.94% - 99.94%
Forma y color:Solid
Peso molecular:350.37
Ref: TM-T5492
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Protosappanin A
CAS:
- 102036-28-2
Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.
Fórmula:C₁₅H₁₂O₅
Pureza:99.42% - 99.82%
Forma y color:Solid
Peso molecular:272.25
Ref: TM-TJS1779
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AG490
CAS:
- 133550-30-8
AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.
Fórmula:C₁₇H₁₄N₂O₃
Pureza:98.6% - 99.85%
Forma y color:Yellow Solid
Peso molecular:294.3
Ref: TM-T2600
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SAR-20347
CAS:
- 1450881-55-6
SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
Fórmula:C₂₁H₁₈ClFN₄O₄
Pureza:98.99% - 99.77%
Forma y color:Solid
Peso molecular:444.84
Ref: TM-T4210
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RO8191
CAS:
- 691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
Fórmula:C₁₄H₅F₆N₅O
Pureza:98% - 98.85%
Forma y color:Solid
Peso molecular:373.21
Ref: TM-T22142
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SMI-16a
CAS:
- 587852-28-6
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (
Fórmula:C₁₃H₁₃NO₃S
Pureza:99.99%
Forma y color:Solid
Peso molecular:263.31
Ref: TM-T3989
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WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.
Fórmula:C₁₆H₁₄Br₂ClN₃O₃
Pureza:99.49%
Forma y color:Solid
Peso molecular:491.56
Ref: TM-T4657L
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Gandotinib
CAS:
- 1229236-86-5
LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).
Fórmula:C₂₃H₂₅ClFN₇O
Pureza:99.33% - 99.86%
Forma y color:Solid
Peso molecular:469.94
Ref: TM-T2638
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Momelotinib HCl
CAS:
- 1380317-28-1
Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.
Fórmula:C₂₃H₂₄Cl₂N₆O₂
Forma y color:Solid
Peso molecular:487.38
Ref: TM-T70823
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XL019
CAS:
- 945755-56-6
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.
Fórmula:C₂₅H₂₈N₆O₂
Pureza:99.19%
Forma y color:Solid
Peso molecular:444.53
Ref: TM-T3072
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Peramivir Trihydrate
CAS:
- 1041434-82-5
Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are
Fórmula:C₁₅H₂₈N₄O₄·3H₂O
Pureza:99.52% - ≥95%
Forma y color:Solid
Peso molecular:382.45
Ref: TM-T2522
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TCS-PIM-1-4a
CAS:
- 327033-36-3
SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).
Fórmula:C₁₁H₆F₃NO₂S
Pureza:99.89%
Forma y color:Solid
Peso molecular:273.23
Ref: TM-T4215