Señalización JAK / STAT
Los inhibidores de la señalización JAK/STAT son compuestos que interrumpen la vía de la cinasa Janus (JAK) y del transductor y activador de la transcripción (STAT), la cual está involucrada en la señalización de citoquinas, el crecimiento celular y la respuesta inmunitaria. Estos inhibidores son herramientas importantes para estudiar la regulación de esta vía y su papel en diversas enfermedades, como el cáncer, los trastornos inmunitarios y las condiciones inflamatorias. Los inhibidores de JAK/STAT también están siendo desarrollados como terapias dirigidas para estas enfermedades. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de la señalización JAK/STAT para apoyar su investigación en biología molecular, oncología e inmunología.
Subcategorías de "Señalización JAK / STAT"
Se han encontrado 394 productos para "Señalización JAK / STAT".
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Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.Fórmula:C17H20N8O2SPureza:99.93%Forma y color:SoildPeso molecular:400.458Ref: TM-T67758
1mg54,00€5mg105,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg309,00€50mg489,00€100mg707,00€Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Fórmula:C14H17N3O3Pureza:99.92%Forma y color:SolidPeso molecular:275.3Ilginatinib
CAS:Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H20FN7Pureza:98.4% - 99.01%Forma y color:SolidPeso molecular:389.4288Ref: TM-T12266
1mg60,00€1mL*10mM (DMSO)126,00€5mg131,00€10mg177,00€25mg259,00€50mg371,00€100mg532,00€200mg705,00€Bromisoval
CAS:Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.Fórmula:C6H11BrN2O2Pureza:98.86%Forma y color:SolidPeso molecular:223.068Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Fórmula:C12H9N3O5Pureza:99.79% - 99.95%Forma y color:Yellow SolidPeso molecular:275.217Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Fórmula:C25H26F2N6O2Pureza:99.58%Forma y color:Yellow SolidPeso molecular:480.51KT-333
CAS:KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Fórmula:C60H74ClN10O14PSPureza:98.12% - 99.53%Forma y color:White SolidPeso molecular:1257.78Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Fórmula:C26H29F3N5O7PPureza:99.75% - 99.79%Forma y color:SolidPeso molecular:611.51Ref: TM-T12477
1mg93,00€5mg205,00€1mL*10mM (DMSO)268,00€10mg313,00€25mg562,00€50mg788,00€100mg1.099,00€Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H21ClFN7Pureza:99.55%Forma y color:SolidPeso molecular:425.89Ref: TM-T12266L2
1mg70,00€5mg150,00€1mL*10mM (DMSO)166,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg973,00€Ilginatinib maleate
CAS:Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C25H24FN7O4Pureza:99.74% - 99.82%Forma y color:SolidPeso molecular:505.501Ref: TM-T12266L
1mg46,00€5mg92,00€1mL*10mM (DMSO)102,00€10mg128,00€25mg180,00€50mg260,00€100mg371,00€200mg494,00€JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Fórmula:C23H24N2OPureza:98.36% - 99.15%Forma y color:SolidPeso molecular:344.4495Ref: TM-T3042
2mg37,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg80,00€25mg148,00€50mg259,00€100mg477,00€500mg1.063,00€STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.Fórmula:C22H14N4O3Pureza:99.61%Forma y color:SolidPeso molecular:382.37Ref: TM-T60160
500mgA consultar5mg60,00€1mL*10mM (DMSO)60,00€10mg96,00€25mg168,00€50mg268,00€100mg404,00€Niclosamide
CAS:Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.Fórmula:C13H8Cl2N2O4Pureza:98.47% - 99.1%Forma y color:Yellow SolidPeso molecular:327.12Brepocitinib P-Tosylate
CAS:Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Fórmula:C25H29F2N7O4SPureza:99.82% - 99.97%Forma y color:SolidPeso molecular:561.604Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Fórmula:C24H28N8O2Pureza:98.06% - 99.94%Forma y color:SolidPeso molecular:460.5315Ref: TM-T14331
1mg39,00€5mg84,00€1mL*10mM (DMSO)85,00€10mg116,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€Delgocitinib
CAS:Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Fórmula:C16H18N6OPureza:99.95%Forma y color:White SolidPeso molecular:310.3537Ref: TM-T15096
1mg160,00€5mg295,00€1mL*10mM (DMSO)330,00€10mg462,00€25mg879,00€50mg1.341,00€100mg1.953,00€200mg2.628,00€WDR5-IN-6
CAS:WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Fórmula:C13H8Cl2N2O2SPureza:99.69%Forma y color:SoildPeso molecular:327.186N-(3-Aminopropyl)cyclohexylamine
CAS:N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Fórmula:C9H20N2Pureza:98.82% - 99.98%Forma y color:SolidPeso molecular:156.2685Golidocitinib
CAS:Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Fórmula:C25H31N9O2Pureza:98.87% - 99.88%Forma y color:Yellow SolidPeso molecular:489.5727PROTAC JAK2 degrader-1
PROTAC JAK2 degrader-1 (Compound 10i) is a JAK2 PROTAC degrader with a DC50 of 27.35 nM against JAK2V617F. It facilitates the ubiquitination and degradation of JAK2. This compound also inhibits the phosphorylation of JAK2, STAT3, and STAT5, and is applicable in the study of myeloproliferative neoplasms.
