Pim
Las quinasas Pim son una familia de quinasas serina/treonina que juegan un papel clave en la supervivencia celular, la proliferación y la apoptosis. Estas quinasas son efectores aguas abajo en la vía de señalización JAK/STAT y están involucradas en varios procesos fisiológicos, incluidas las respuestas inmunitarias y la hematopoyesis. La sobreexpresión de las quinasas Pim se ha asociado con el desarrollo de cáncer, lo que las convierte en objetivos importantes para la intervención terapéutica. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de quinasas Pim de alta calidad para apoyar su investigación en oncología, biología celular y transducción de señales.
Se han encontrado 32 productos para "Pim".
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AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Fórmula:C18H23N3O3SPureza:99.49%Forma y color:SolidPeso molecular:361.46M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Fórmula:C22H28ClN5O3Pureza:99.55%Forma y color:Orange SolidPeso molecular:445.94PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Fórmula:C17H11ClN4OPureza:98.81%Forma y color:SolidPeso molecular:322.75FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Fórmula:C21H20F2N4O2SPureza:98%Forma y color:SolidPeso molecular:430.47GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Fórmula:C22H24N8OPureza:98%Forma y color:SolidPeso molecular:416.48PIM1-IN-4
CAS:PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Fórmula:C27H25BrCl2CuN6OPureza:98%Forma y color:SolidPeso molecular:663.88Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Fórmula:C22H13Cl2N3OPureza:98%Forma y color:SolidPeso molecular:406.26PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Fórmula:C25H30N8O2Pureza:98.59%Forma y color:Yellow SolidPeso molecular:474.56PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Fórmula:C19H22N4O2Pureza:98%Forma y color:SolidPeso molecular:338.4Pim-1 kinase inhibitor 6
CAS:Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].Fórmula:C21H10BrCl2N3Forma y color:SolidPeso molecular:455.13GDC-0339
CAS:GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Fórmula:C20H22F3N7OSForma y color:SolidPeso molecular:465.5CRT0066101
CAS:CRT0066101 is a potent and orally active protein kinase D inhibitor with low-nanomolar activity against PKD1, PKD2, and PKD3, while also inhibiting PIM2, CRT0066101 demonstrates significant anti-inflammatory efficacy in lipopolysaccharide-induced lung injury models as well as anticancer activity, supporting its use in inflammation and oncology research.Fórmula:C18H22N6OForma y color:SolidPeso molecular:338.41
