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Pim

Pim

Las quinasas Pim son una familia de quinasas serina/treonina que juegan un papel clave en la supervivencia celular, la proliferación y la apoptosis. Estas quinasas son efectores aguas abajo en la vía de señalización JAK/STAT y están involucradas en varios procesos fisiológicos, incluidas las respuestas inmunitarias y la hematopoyesis. La sobreexpresión de las quinasas Pim se ha asociado con el desarrollo de cáncer, lo que las convierte en objetivos importantes para la intervención terapéutica. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de quinasas Pim de alta calidad para apoyar su investigación en oncología, biología celular y transducción de señales.

Se han encontrado 35 productos para "Pim".

productos por página.
  • VB1080
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    VB1080

    VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.
    Fórmula:C27H27N3O3
    Forma y color:Solid
    Peso molecular:441.522

    Ref: TM-T204937

  • PIM-1 Inhibitor 2
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    PIM-1 Inhibitor 2

    CAS:
    PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.
    Fórmula:C17H11ClN4O
    Pureza:98.81%
    Forma y color:Solid
    Peso molecular:322.75

    Ref: TM-T23158

  • K00135
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    K00135

    CAS:
    K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.
    Fórmula:C18H18N4O
    Pureza:98.16%
    Forma y color:Yellow Solid
    Peso molecular:306.3617

    Ref: TM-T27704

  • AZD-1897
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    AZD-1897

    CAS:
    AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.
    Fórmula:C18H23N3O3S
    Pureza:99.91%
    Forma y color:Solid
    Peso molecular:361.46

    Ref: TM-T71242

  • M-110
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    M-110

    CAS:
    M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).
    Fórmula:C22H28ClN5O3
    Pureza:99.55%
    Forma y color:Orange Solid
    Peso molecular:445.942

    Ref: TM-T15830

  • CX-6258
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    CX-6258

    CAS:
    CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.
    Fórmula:C26H24ClN3O3
    Pureza:97.46%
    Forma y color:Solid
    Peso molecular:461.94

    Ref: TM-T1834

  • PIM1-IN-1
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    PIM1-IN-1

    CAS:
    PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.
    Fórmula:C25H30N8O2
    Pureza:98.59%
    Forma y color:Yellow Solid
    Peso molecular:474.5581

    Ref: TM-T12474

  • Pim-1 kinase inhibitor 5
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    Pim-1 kinase inhibitor 5

    CAS:
    Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-
    Fórmula:C22H13Cl2N3O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:406.26

    Ref: TM-T78980

  • FD1024
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    FD1024

    CAS:
    FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.
    Fórmula:C21H20F2N4O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:430.47

    Ref: TM-T79456

  • PIM-IN-2
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    PIM-IN-2

    CAS:
    PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .
    Fórmula:C19H22N4O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:338.4

    Ref: TM-T81460

  • PIM1-IN-4
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    PIM1-IN-4

    CAS:
    PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.
    Fórmula:C27H25BrCl2CuN6O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:663.88

    Ref: TM-T73247

  • GNE-955
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    GNE-955

    CAS:
    GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
    Fórmula:C22H24N8O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:416.48

    Ref: TM-T15406

  • GDC-0339
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    GDC-0339

    CAS:
    GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.
    Fórmula:C20H22F3N7OS
    Forma y color:Solid
    Peso molecular:465.495

    Ref: TM-T15376

  • CRT0066101
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    CRT0066101

    CAS:
    CRT0066101 is a potent and orally active protein kinase D inhibitor with low-nanomolar activity against PKD1, PKD2, and PKD3, while also inhibiting PIM2, CRT0066101 demonstrates significant anti-inflammatory efficacy in lipopolysaccharide-induced lung injury models as well as anticancer activity, supporting its use in inflammation and oncology research.
    Fórmula:C18H22N6O
    Forma y color:Solid
    Peso molecular:338.41

    Ref: TM-T86093

  • Pim-1 kinase inhibitor 6
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    Pim-1 kinase inhibitor 6

    CAS:
    Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].
    Fórmula:C21H10BrCl2N3
    Forma y color:Solid
    Peso molecular:455.13

    Ref: TM-T87213