JNK

Tanzisertib (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with …

SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).

NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

Mefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ …

Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.

Chloramphenicol, a broad-spectrum antibiotic, blocks bacterial protein synthesis.

Mefloquine is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.

Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in …

Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both …

Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly …

Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and …

AS601245.2TFA is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for …

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it …

Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value …

6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen …

Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling …

JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity …

Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, …

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in …

Astragaloside, one of the main active ingredients in Astragalus membranaceus.

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can …

Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 …

d-Epigalbacin is a naturally occurring lignin. d-Epigalbacin is a potent, selective JNKs inhibitor, with IC50s …

Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 …

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C …

D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor.

JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity …

Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in …

Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity …

Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the …

Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.

3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.

Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in …

Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 …

Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and …

Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate …

Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it …

OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.

Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death …

Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a …

Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also …

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on …

1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity …

Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) …

1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic …

Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of …

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. …

Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the …

Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer …

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced …

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also …

Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation …

Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of …

Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione …

GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 …

TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase …

JNK Inhibitor VIII is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of …

Sodium taurochenodeoxycholate is one of the main bioactive substances of animals' bile acid. Sodium taurochenodeoxycholate …

AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.

DB07268 is a potent and selective JNK1 inhibitor.

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression

1. Isovitexin exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits …

TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).

IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, …

D-JNKI-1 acetate is a highly potent and cell-permeable peptide inhibitor of JNK.

CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over …