CAS 56-75-7

(-)-Cloranfenicol

Descripción:

(-)-Cloranfenicol, con el número CAS 56-75-7, es un antibiótico de amplio espectro derivado originalmente de la bacteria Streptomyces venezuelae. Se caracteriza por su capacidad para inhibir la síntesis de proteínas bacterianas al unirse a la subunidad 50S del ribosoma bacteriano, bloqueando efectivamente la formación de enlaces peptídicos. Este compuesto es un polvo cristalino blanco a blanco sucio que es soluble en agua y alcohol, pero tiene una solubilidad limitada en disolventes orgánicos. Su fórmula molecular es C11H12Cl2N2O5, y tiene un peso molecular de aproximadamente 323.13 g/mol. (-)-Cloranfenicol exhibe actividad antibacteriana contra una amplia gama de bacterias Gram-positivas y Gram-negativas, lo que lo hace útil en el tratamiento de diversas infecciones. Sin embargo, su uso está limitado debido a posibles efectos secundarios, incluyendo anemia aplásica y síndrome del bebé gris en recién nacidos. Como resultado, a menudo se reserva para infecciones graves donde otros antibióticos son ineficaces. El manejo y la dosificación adecuados son cruciales para minimizar los efectos adversos y garantizar la eficacia terapéutica.

Fórmula:C₁₁H₁₂Cl₂N₂O₅

InChI:InChI=1/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9?/m1/s1

Clave InChI:InChIKey=WIIZWVCIJKGZOK-RKDXNWHRSA-N

SMILES:[C@@H]([C@H](NC(C(Cl)Cl)=O)CO)(O)C1=CC=C(N(=O)=O)C=C1

Sinónimos:

2,2-Dichloro-N-(2-Hydroxy-1-(Hydroxymethyl)-2-(4-Nitrophenyl)Ethyl)-Acetamid
2,2-Dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
2,2-Dichloro-N-[2-Hydroxy-1-(Hydroxymethyl)-2-(4-Nitrophenyl)Ethyl]Acetamide
2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
2,2-dichloro-N-[(1R,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
2,2-dichloro-N-[(1S,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Ak-Chlor
Alficetyn
Amphenicol
Amphicol
Amseclor
Anacetin
Aquamycetin
Austracol
Bradyoxetin
CAF
CAM
CAP
CPh
Catilan
Chemicetin
Chemicetina
Chlomycol
Chloramex
Chloramphenicol
Chloramsaar
Chlorasol
Chlorcetin
Chloricol
Chlorocaps
Chlorocid
Chlorocide
Chlorocin
Chloromycetin
Chloronitrin
Chloroptic
Ciplamycetin
Cloramfen
Cloramfenicol
Cloramficin
Cloramicol
Clorocyn
Cloromisan
Cylphenicol
D-(-)-Chloramphenicol
D-(-)-Threo-2,2-Dichloro-N-[Beta-Hydroxy-Alpha-(Hydroxy-Methyl)-P-Nitrophenethyl]Acetamide
D-(-)-threo-1-(4-Nitrophenyl)-2-dichloroacetamido-1,3-propanediol
D-(-)-threo-1-p-Nitrophenyl-2-dichloracetamido-1,3-propanediol
D-(-)-threo-1-p-Nitrophenyl-2-dichloroacetylamino-1,3-propanediol
D-(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol
D-(-)-threo-Chloramphenicol
D-threo-(1R,2R)-1-p-Nitrophenyl-2-dichloroacetamido-1,3-propanediol
D-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol
Detreomycin
Embacetin
Enicol
Enteromycetin
Farmicetina
Fenicol
Globenicol
Gloveticol
Halcetin
Intramycetin
Ismicetina
Juvamycetin
Kamaver
Kemicetine
Klorita
Leukomyan
Leukomycin
Levocin
Levomicetina
Levomitsetin
Levomycetin
Levoplast
Levosin
Levovetin
Loromisin
Mastiphen
Micloretin
Micoclorina
Microcetina
Mychel
Mychel-Vet
Mycinol
Myclocin
Mycochlorin
Novomycetin
Ocuphenicol
Opclor
Ophthochlor
Pantovernil
Paraxin
Quemicetina
Ronphenil
Septicol
Sintomicetin
Sintomicetina
Soluthor
Stanomycetin
Synthomycetin
Synthomycin
Tevcocin
Tifomycine
Treomicetina
Unimycetin
Veticol
Viceton
[R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
D,L-chloramphenicol
Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-
nitrophenyl)ethyl]acetamide
Acetamide, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-
Acetamide, 2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-
2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-
D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-4-NITROPHENETHYL]ACETAMIDE
D-THREO-(-)-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-HYDROXYMETHYL-P-NITROPHENETHYL]ACETAMIDE
D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-4-NITROPHENYL] ACETAMIDE
D-THREO-2-DICHLOROACETAMIDO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
D-2-DICHLOROACETAMIDO-1-P-NITRO-PHENYL-1,3-PROPANEDIOL
[R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide
D(-)-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-BETA-(4-NITROPHENYL)ETHYL]ACETAMIDE
D(-)-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXY-METHYL)-P-NITROPHENYLETHYL]ACETAMIDE
D-(-)-THREO-2-DICHLOROACETAMIDO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
CHLORAMPHENICOLUM
D-(-)-THREO-2-DICHLOROACETAMIDO-1-[P-NITRO-PHENYL]-1,3-PROPANEDIOL
,[theta-(theta,theta)]-
D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA(HYDROXYMETHYL)-BETA-(4-NITROPHENYL)ETHYL]ACETAMIDE
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