cAMP

Onjisaponin F(Polygalasaponin XXXI) acts non-competitively against cyclic AMP phosphodiesterase, like papaverine; it also exhibits a …

Mirabegron is a beta-3 adrenergic agonist that is used for treatment of overactive bladder syndrome.

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).

CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1; IC50s of …

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride …

ESI-05 is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 …

Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP …

JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 …

MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, …

HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated …

Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to …

Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, …

Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis; …

Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects …

Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through …

Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition …

BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 …

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced …

TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.

TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 …

4,5-Dimethoxycanthin-6-one has antibacterial actiyity, it exhibits inhibition against Staphylococcus aureus and its drug-resistant strains. 4,5-Dimethoxycanthin-6-one …

Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation …

Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it …

Vidupiprant is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of …

KI-7 is an adenosine A2B receptor positive allosteric modulator.

Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO …

Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium …

Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it …

Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase …

Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling …

Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can …

ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the …

Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it …

Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and …

PSN 375963 hydrochloride is a synthetic agonist of the endogenous ligand for GPR119.

Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and …

Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine exerts a non-specific …

ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and …

Adenosine cyclophosphate combined with vitamin C treatment of children with viral myocarditis has exact curative …

LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).

WAY-181187 has high-affinity binding at the human 5-HT6 receptor.

Forskolin, a potent activator of the adenylate cyclase (EC50: 0.5 μM), can increase the cAMP …

Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM …

KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM …

CJ-42794 is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 …

3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a …

7-O-Methylrosmanol can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and …

Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). …

HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of …

NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating …

RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor

Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G …

Piclamilast is a PDE4 inhibitor.

Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.

Moschamine is a very potent compound that is able to inhibit COX-I by 58% and …

Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in …

Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and …

LGD-6972 is an antagonist of glucagon receptor.

EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 µM in …

ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively …