MNK
Las MNK (quinasas interactuantes con MAPK) son un grupo de quinasas que interactúan con las MAPK, particularmente ERK y p38, para regular la síntesis de proteínas mediante la fosforilación del factor de iniciación eucariota 4E (eIF4E). La señalización de MNK juega un papel en las respuestas celulares al estrés, la inflamación y la progresión del cáncer. Dirigir las MNK es una estrategia emergente en la terapia contra el cáncer y los tratamientos antiinflamatorios. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de MNK para apoyar su investigación en la regulación de la síntesis de proteínas, oncología e inflamación.
Se han encontrado 14 productos de "MNK"
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ETC-206
CAS:<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Forma y color:SolidPeso molecular:408.45NUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Forma y color:Odour SolidQL-X-138 HCl
<p>QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.</p>Fórmula:C25H20ClN5O2Pureza:99.25%Forma y color:SoildPeso molecular:457.91MNK-IN-4
<p>MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor used in treating acute spleen injury related to sepsis.</p>Fórmula:C15H17N5Peso molecular:267.1484HSND80
<p>HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.</p>Forma y color:Odour SolidTomivosertib HCl
CAS:<p>Tomivosertib (eFT508) is a MNK1/2 inhibitor that blocks eIF4E phosphorylation, hindering tumor growth and immune signaling.</p>Fórmula:C17H21ClN6O2Forma y color:SolidPeso molecular:376.845Tomivosertib
CAS:<p>Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.</p>Fórmula:C17H20N6O2Pureza:97.34% - 99.72%Forma y color:SolidPeso molecular:340.38CGP 57380
CAS:<p>CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like</p>Fórmula:C11H9FN6Pureza:98.49%Forma y color:SolidPeso molecular:244.23SLV-2436
CAS:<p>SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).</p>Fórmula:C19H15ClN4OPureza:98.56%Forma y color:SolidPeso molecular:350.8HG-10-102-01
CAS:<p>HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).</p>Fórmula:C17H20ClN5O3Pureza:99.59%Forma y color:SolidPeso molecular:377.83ETC-168
CAS:<p>ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].</p>Fórmula:C24H19N5O2Forma y color:SolidPeso molecular:409.44MNK1/2-IN-5
CAS:<p>MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.</p>Fórmula:C17H16N4O2Pureza:98.04%Forma y color:SolidPeso molecular:308.33DS12881479
CAS:<p>DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].</p>Fórmula:C16H19N3OSPureza:99.85%Forma y color:SolidPeso molecular:301.41MNK inhibitor 9
CAS:<p>MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.</p>Fórmula:C25H29N9OForma y color:SolidPeso molecular:471.56
