MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 892 productos de "MAPK"
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ETC-206
CAS:<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Fórmula:C25H20N4O2Pureza:99.72% - 99.79%Forma y color:SolidPeso molecular:408.45ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Fórmula:C50H62N14O6S2Pureza:99.24%Forma y color:SolidPeso molecular:1019.25JNK-IN-13
CAS:<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Fórmula:C13H7ClN4SPureza:98.74%Forma y color:SolidPeso molecular:286.74CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Forma y color:SolidPeso molecular:458.44K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Fórmula:C31H33ClN4O4Pureza:99.00%Forma y color:SolidPeso molecular:561.07Ref: TM-T11738
1mg74,00€5mg170,00€10mg250,00€25mg424,00€50mg562,00€100mg827,00€200mg1.111,00€1mL*10mM (DMSO)202,00€(R)-Ketorolac
CAS:<p>(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.</p>Fórmula:C15H13NO3Pureza:99.55%Forma y color:SolidPeso molecular:255.27Cephradine
CAS:Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.Fórmula:C16H19N3O4SPureza:99.63%Forma y color:White Crystalline Powder; Polymorphic SolidPeso molecular:349.40MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:97.3% - 99.07%Forma y color:SolidPeso molecular:565.71Ref: TM-T16143
1mg64,00€2mg89,00€5mg131,00€10mg207,00€25mg371,00€50mg540,00€100mg785,00€200mgA consultar1mL*10mM (DMSO)170,00€TINK-IN-1
CAS:TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Fórmula:C24H24N4O3Pureza:99.4%Forma y color:SoildPeso molecular:416.47Ref: TM-T77660
1mg42,00€2mg52,00€5mg87,00€10mg127,00€25mg250,00€50mg373,00€100mg547,00€500mg1.159,00€INH154
CAS:INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Fórmula:C22H24N4OSPureza:99.95%Forma y color:SolidPeso molecular:392.52Ref: TM-T11657
2mg37,00€5mg57,00€10mg87,00€25mg143,00€50mg215,00€100mg316,00€200mg439,00€1mL*10mM (DMSO)63,00€SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Fórmula:C5H3N5O2S3Pureza:98.39%Forma y color:SolidPeso molecular:261.3Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Fórmula:C24H19ClN4O4Pureza:95.77% - 98.83%Forma y color:SolidPeso molecular:462.89BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.2% - 99.66%Forma y color:SolidPeso molecular:462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€HI-TOPK-032
CAS:<p>HI-TOPK-032 is an effective and specific inhibitor of TOPK.</p>Fórmula:C20H11N5OSPureza:98.52%Forma y color:SolidPeso molecular:369.4Azelnidipine
CAS:Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.Fórmula:C33H34N4O6Pureza:99.78%Forma y color:Light Yellowish PowderPeso molecular:582.65Ref: TM-T0121
2mg35,00€5mg52,00€10mg67,00€25mg109,00€50mg170,00€100mg274,00€200mg406,00€1mL*10mM (DMSO)63,00€ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Fórmula:C19H16ClN3OPureza:99.89%Forma y color:SoildPeso molecular:337.8Ref: TM-T77734
1mg86,00€2mg111,00€5mg180,00€10mg279,00€25mg562,00€50mg917,00€100mg1.454,00€500mg2.822,00€ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Fórmula:C21H17ClF2N4O2Pureza:97.78%Forma y color:SolidPeso molecular:430.84Ref: TM-T10376
1mg40,00€5mg90,00€10mg118,00€25mg229,00€50mg328,00€100mg430,00€200mg612,00€1mL*10mM (DMSO)94,00€Divarasib
CAS:<p>Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.</p>Fórmula:C29H32ClF4N7O2Pureza:99.237% - 99.83%Forma y color:SolidPeso molecular:622.06Pepinh-TRIF TFA
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interactionFórmula:C180H279F3N58O40S2Pureza:98%Forma y color:SolidPeso molecular:4014.09741MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Fórmula:C21H18N4O2Pureza:99.58%Forma y color:SolidPeso molecular:358.39Ref: TM-T12058
1mg35,00€5mg64,00€10mg93,00€25mg180,00€50mg264,00€100mg369,00€200mg507,00€1mL*10mM (DMSO)78,00€Tanzisertib
CAS:Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Fórmula:C21H23F3N6O2Pureza:98.66% - 99.28%Forma y color:SolidPeso molecular:448.44Ref: TM-T14895
1mg42,00€5mg87,00€10mg145,00€25mg283,00€50mg558,00€100mg743,00€200mg1.026,00€1mL*10mM (DMSO)96,00€MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Fórmula:C15H12ClN5Pureza:98.07%Forma y color:SolidPeso molecular:297.74Ref: TM-T11942
5mg47,00€10mg79,00€25mg153,00€50mg235,00€100mg374,00€200mg552,00€500mg840,00€1mL*10mM (DMSO)50,00€PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Fórmula:C21H18N4OSPureza:98.13%Forma y color:SolidPeso molecular:374.46Ref: TM-T16501
1mg37,00€5mg111,00€10mg202,00€25mg416,00€50mg620,00€100mg832,00€500mg1.663,00€1mL*10mM (DMSO)187,00€Regorafénib N-oxyde (M2)
CAS:<p>Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.</p>Fórmula:C21H15ClF4N4O4Pureza:98.03% - 98.26%Forma y color:SolidPeso molecular:498.81KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Fórmula:C25H19ClF2N4O3SPureza:97.46%Forma y color:SolidPeso molecular:528.96B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Fórmula:C20H17F2N5O4SPureza:98.86%Forma y color:SolidPeso molecular:461.44LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Fórmula:C27H19F3N8OPureza:99.03%Forma y color:SolidPeso molecular:528.49MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Fórmula:C22H24N6OPureza:99.69%Forma y color:SolidPeso molecular:388.47ERK5-IN-6
CAS:<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Fórmula:C23H21N3Pureza:98.59%Forma y color:SoildPeso molecular:339.43AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Fórmula:C32H40N8O5SPureza:98.96%Forma y color:SolidPeso molecular:648.78Ref: TM-T14360
1mg57,00€2mg81,00€5mg120,00€10mg170,00€25mg298,00€50mg424,00€100mg597,00€500mg1.225,00€1mL*10mM (DMSO)167,00€MRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Fórmula:C22H21N3Forma y color:SolidPeso molecular:327.42NK7-902
NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.Forma y color:Odour SolidVacquinol-1
CAS:Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Fórmula:C21H21ClN2OPureza:99.92%Forma y color:SolidPeso molecular:352.86PROTAC KRAS G12C degrader-1
<p>PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells</p>Fórmula:C50H54ClFN8O6Pureza:98%Forma y color:SolidPeso molecular:917.47Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFórmula:C18H13N3OSPureza:99.82%Forma y color:SolidPeso molecular:319.38Ref: TM-T67942
1mg57,00€5mg123,00€10mg180,00€25mg293,00€50mg393,00€100mg538,00€200mg725,00€1mL*10mM (DMSO)190,00€Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Fórmula:C19H30O3Forma y color:SolidPeso molecular:306.44SEPT9-IN-1
SEPT9-IN-1 (compound 8b) is a SEPT9 inhibitor with an IC50 value of 94.83 μM. It exhibits cytotoxicity against human oral squamous carcinoma cells, with an IC50 of 21 µM.Fórmula:C26H30ClN3O3Forma y color:SolidPeso molecular:467.988GNE-9815
CAS:GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selectiveFórmula:C26H22FN5O2Pureza:99.08% - 99.1%Forma y color:SolidPeso molecular:455.48Ref: TM-T9585
1mg64,00€5mg145,00€10mg226,00€25mg378,00€50mg538,00€100mg730,00€500mg1.464,00€1mL*10mM (DMSO)145,00€CC-401
CAS:<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Fórmula:C22H24N6OPureza:98%Forma y color:SolidPeso molecular:388.47Rutamycin
CAS:Rutamycin: a macrolide antibiotic from Streptomyces rutgersensis; blocks ATPases, uncouples oxidative phosphorylation.Fórmula:C44H72O11Pureza:98%Forma y color:SolidPeso molecular:777.049JIP-1(153-163)
CAS:Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.Fórmula:C61H104N20O14Pureza:98%Forma y color:SolidPeso molecular:1341.6PROTAC SOS1 degrader-1
CAS:PROTAC SOS1 degrader-1: potent, DC50 98.4 nM, inhibits KRAS mutant cancer cells, low-toxic antitumor.Fórmula:C57H76O4ClFN10SForma y color:SoildPeso molecular:1050.54443p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Fórmula:C16H13FN2OS2Pureza:98.53%Forma y color:SolidPeso molecular:332.42Rapaprutug
CAS:Rapaprutug is a monoclonal antibody that targets human KARS1 (lysyl-tRNA synthetase 1). It can block inflammation-related signaling pathways involving KARS1, thereby reducing the production and release of inflammatory factors. Rapaprutug shows potential for research into inflammatory diseases.Forma y color:LiquidEdaxeterkib
CAS:Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.Fórmula:C26H27N7O2Forma y color:SolidPeso molecular:469.549MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Fórmula:C28H29F3N6O5SForma y color:SolidPeso molecular:618.63U0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFórmula:C8H10N4S2Pureza:98%Forma y color:SolidPeso molecular:226.32MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Fórmula:C28H23F3IN3O4Forma y color:SolidPeso molecular:649.4Rineterkib hydrochloride
CAS:Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.Fórmula:C26H28BrClF3N5O2Forma y color:SolidPeso molecular:614.89Pan-RAS-IN-7
CAS:Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Fórmula:C59H76N8O8Forma y color:SolidPeso molecular:1025.28PROTAC K-Ras Degrader-2
CAS:PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.Fórmula:C52H60F4N8O5Forma y color:SolidPeso molecular:953.077KRAS G12C inhibitor 18
CAS:KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Fórmula:C25H20ClFN4O3SForma y color:SolidPeso molecular:510.97PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.Fórmula:C46H55F2N9O9SForma y color:SolidPeso molecular:948.05RM-018
CAS:RM-018 inhibits active KRAS G12C & G12C/Y96D, possibly beating resistance with unique traits.Fórmula:C56H72N8O8Forma y color:SolidPeso molecular:985.24L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Fórmula:C164H286N66O40Pureza:98%Forma y color:SolidPeso molecular:3822.44KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Fórmula:C31H30F5N7O2Pureza:98%Forma y color:SolidPeso molecular:627.61Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarMAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Forma y color:Odour SolidRef: TM-L1400
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarPDE4-IN-26
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.Fórmula:C22H18F2N4O3SForma y color:SolidPeso molecular:456.47Debromohymenialdisine
CAS:Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.Fórmula:C11H11N5O2Forma y color:SolidPeso molecular:245.242Z16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Fórmula:C18H17N3O4SPureza:99.18%Forma y color:SolidPeso molecular:371.41S6 Kinase Substrate Peptide 32
S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.Fórmula:C149H270N56O49Pureza:98%Forma y color:SolidPeso molecular:3630.1Mitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Pureza:98%Forma y color:SolidSOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Fórmula:C26H29F3N4O2Forma y color:SolidPeso molecular:486.534′-Demethylnobiletin
CAS:<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Fórmula:C20H20O8Forma y color:SolidPeso molecular:388.37KRAS G12D inhibitor 7
CAS:KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.Fórmula:C32H38N8O3Forma y color:SolidPeso molecular:582.709RTIL 13
CAS:RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).Fórmula:C30H55BrN2O3Forma y color:SolidPeso molecular:571.685Ras Inhibitory Peptide acetate
<p>Ras Inhibitory Peptide acetate, involved in cancer-related Ras signaling.</p>Fórmula:C55H95N19O13Pureza:96.63%Forma y color:SolidPeso molecular:1230.46(S)-BAY-293
CAS:<p>(S)-BAY-293 is a potent pan-KRAS inhibitor for the study of primary non-small lung and pancreatic cancers.</p>Fórmula:C25H28N4O2SPureza:98%Forma y color:SolidPeso molecular:448.58ADT-007
CAS:<p>ADT-007 is a pan-RAS inhibitor with potent anticancer activity.</p>Fórmula:C26H24FNO5Pureza:97.75%Forma y color:SoildPeso molecular:449.47(R)-BI-2852
CAS:(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Fórmula:C31H28N6O2Pureza:97.78%Forma y color:SoildPeso molecular:516.59PROTAC K-Ras Degrader-6
CAS:Pan-KRAS degrader 5 (compound 102) is a cereblon-based PROTAC KRAS degrader with a DC50 value less than 100 nM, exhibiting anticancer activity.Fórmula:C57H65F2N11O5Forma y color:SolidPeso molecular:1022.19BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Fórmula:C19H16N2O4Pureza:99.78%Forma y color:SolidPeso molecular:336.34Ref: TM-T67854
1mg89,00€5mg178,00€10mg264,00€25mg393,00€50mg552,00€100mg752,00€200mg1.008,00€1mL*10mM (DMSO)178,00€MC 976
CAS:MC 976 is a derivative of Vitamin D3.Fórmula:C27H42O3Pureza:98%Forma y color:SolidPeso molecular:414.63KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Fórmula:C51H65F4N9O9S2Forma y color:SolidPeso molecular:1088.24HPK1-IN-39
HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes theFórmula:C26H27N7O2Forma y color:SolidPeso molecular:469.54YN14
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with lowPureza:98%Forma y color:Odour SolidLYMTAC-2
LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.Forma y color:SolidPeso molecular:1248.44Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Fórmula:C46H60N8O5SForma y color:SolidPeso molecular:837.08PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Fórmula:C54H69N11O6SPureza:98%Forma y color:SolidPeso molecular:1000.26Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Fórmula:C21H21F3IN3O2Pureza:98%Forma y color:SolidPeso molecular:531.318JNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Fórmula:C32H30FN7O3Forma y color:SolidPeso molecular:579.62NUCC-0200808
NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.Forma y color:Odour SolidKRAS inhibitor-38
CAS:KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Fórmula:C53H68ClF2N9O8SForma y color:SolidPeso molecular:1064.68HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Forma y color:Odour SolidSIAIS562055
SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.Fórmula:C49H62F3N7O5SForma y color:SolidPeso molecular:918.12FAM49B (190-198) mouse
CAS:FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.Fórmula:C49H71N9O14SForma y color:SolidPeso molecular:1042.2DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Fórmula:C25H26ClN5O2Forma y color:SolidPeso molecular:463.96KG5
CAS:<p>KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).</p>Fórmula:C20H16F3N7OSPureza:98.32%Forma y color:SolidPeso molecular:459.45PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Fórmula:C53H66FIN8O11S2Pureza:98%Forma y color:SolidPeso molecular:1201.17BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Fórmula:C47H62N8O4SForma y color:SolidPeso molecular:835.11Setidegrasib
CAS:KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.Fórmula:C60H65FN12O7SForma y color:SolidPeso molecular:1117.3LC 2 Epimer
CAS:<p>Negative control for LC 2.</p>Fórmula:C59H71ClFN11O7SForma y color:SolidPeso molecular:1132.8Tagarafdeg
CAS:Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Fórmula:C45H49F2N11O9SPureza:>99.99% - ＞99.99%Forma y color:SolidPeso molecular:958PROTAC K-Ras Degrader-1
CAS:PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligase ligand, capable of degrading K-Ras.Fórmula:C53H62N10O10Pureza:98.05%Forma y color:SolidPeso molecular:999.12SS47
CAS:SS47 is a PROTAC that degrades immunosuppressive HPK1 via proteasome; boosts BCMA CAR-T cell cancer therapy.Fórmula:C49H56N6O12SForma y color:SolidPeso molecular:953.07KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.Fórmula:C29H29ClF3N5O3Forma y color:SolidPeso molecular:588.02R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Fórmula:C101H157N27O29S3Pureza:98%Forma y color:SolidPeso molecular:2309.69Rac1 Inhibitor W56
CAS:Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Fórmula:C74H117N19O23SPureza:98%Forma y color:SolidPeso molecular:1671.93KRAS inhibitor-33
KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.Fórmula:C33H39ClF2N6O3Forma y color:SolidPeso molecular:641.15
