MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 893 productos de "MAPK"
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AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Fórmula:C16H17FIN3O4Pureza:98.72%Forma y color:SolidPeso molecular:461.23methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS:methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.Fórmula:C13H13NO5Pureza:97.69%Forma y color:SolidPeso molecular:263.25RWJ-67657
CAS:<p>RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ with cardioprotection.</p>Fórmula:C27H24FN3OPureza:99.66%Forma y color:SolidPeso molecular:425.5IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Fórmula:C20H11N3O3Pureza:≥98%Forma y color:SolidPeso molecular:341.32B-Raf IN 11
CAS:B-Raf IN 11 is a novel selective inhibitor.Fórmula:C17H14BrF2N3O3SPureza:99.947%Forma y color:SolidPeso molecular:458.28Necrosulfonamide
CAS:<p>Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. High-Quality, Low-Cost!</p>Fórmula:C18H15N5O6S2Pureza:98.85% - 99.49%Forma y color:SolidPeso molecular:461.47APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Fórmula:C23H21N3O3·HClPureza:98.64% - 99.55%Forma y color:SolidPeso molecular:423.89BI-D1870
CAS:BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.Fórmula:C19H23F2N5O2Pureza:98.51% - 99.43%Forma y color:SolidPeso molecular:391.42Skepinone-L
CAS:<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Fórmula:C24H21F2NO4Pureza:99.56% - >99.99%Forma y color:SolidPeso molecular:425.42RAF709
CAS:<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Fórmula:C28H29F3N4O4Pureza:99.28% - 99.8%Forma y color:SolidPeso molecular:542.55ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:99.71%Forma y color:SolidPeso molecular:747.85Maohuoside A
CAS:<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Fórmula:C27H32O12Pureza:98.91% - 99.57%Forma y color:SolidPeso molecular:548.54ERK5-IN-2
CAS:<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Fórmula:C17H11BrFN3O2Pureza:99.01%Forma y color:SolidPeso molecular:388.19K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Forma y color:SolidPeso molecular:405.34PF-4708671
CAS:<p>PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).</p>Fórmula:C19H21F3N6Pureza:99.48% - 99.67%Forma y color:SolidPeso molecular:390.41Vemurafenib
CAS:<p>Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.</p>Fórmula:C23H18ClF2N3O3SPureza:98% - 99.65%Forma y color:SolidPeso molecular:489.92Pimasertib
CAS:<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Fórmula:C15H15FIN3O3Pureza:98.25% - 99.57%Forma y color:SolidPeso molecular:431.2SLV-2436
CAS:SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).Fórmula:C19H15ClN4OPureza:98.56%Forma y color:SolidPeso molecular:350.8(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Forma y color:SolidPeso molecular:560.594ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Fórmula:C19H19N9O2Pureza:99.92%Forma y color:SolidPeso molecular:405.41PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.83%Forma y color:SolidPeso molecular:413.83Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Fórmula:C10H7N3O4SPureza:98.89% - 99.28%Forma y color:SolidPeso molecular:265.25XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Forma y color:SolidPeso molecular:638.8Locostatin
CAS:Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.Fórmula:C14H15NO3Pureza:97.13%Forma y color:SolidPeso molecular:245.27APS6-45
CAS:<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Fórmula:C23H16F8N4O3Pureza:99.39%Forma y color:SolidPeso molecular:548.39S6K-18
CAS:S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.Fórmula:C17H18N4O3SPureza:98.99%Forma y color:SolidPeso molecular:358.41PLX8394
CAS:<p>Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.</p>Fórmula:C25H21F3N6O3SPureza:98.75% - >99.99%Forma y color:SolidPeso molecular:542.53ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Fórmula:C25H29N7O2Pureza:97.70%Forma y color:SolidPeso molecular:459.54BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Forma y color:SolidPeso molecular:379.37PF-06260933 HCl
CAS:PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.Fórmula:C16H15Cl3N4Forma y color:SolidPeso molecular:369.68CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Fórmula:C16H27N5O2Pureza:99.96%Forma y color:SolidPeso molecular:321.42TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Fórmula:C20H13F2N3Pureza:99.35% - 99.79%Forma y color:SolidPeso molecular:333.33IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Forma y color:SolidPeso molecular:377.27Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H15BrF2N4O3Pureza:98.03% - >99.99%Forma y color:SolidPeso molecular:441.23GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Fórmula:C23H21ClN2O3Pureza:99.73%Forma y color:SolidPeso molecular:408.87Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Forma y color:SolidPeso molecular:615.67Tizaterkib
CAS:Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.Fórmula:C24H24F2N8O2Pureza:99.6% - 99.63%Forma y color:SolidPeso molecular:494.5Raf inhibitor 2
CAS:Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.Fórmula:C15H8Br2ClNO2Pureza:98.53%Forma y color:SolidPeso molecular:429.49Theaflavin 3,3′-digallate
CAS:Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFórmula:C43H32O20Pureza:98.71% - 99.86%Forma y color:SolidPeso molecular:868.70BAY885
CAS:<p>BAY885 is a new ERK5 inhibitor.</p>Fórmula:C25H28F3N7O2Pureza:99.83%Forma y color:SolidPeso molecular:515.53CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Forma y color:SolidPeso molecular:424.93LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Fórmula:C23H29FN6OPureza:96.96% - ≥95%Forma y color:SolidPeso molecular:424.51Pluripotin
CAS:Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) andFórmula:C27H25F3N8O2Pureza:98.77% - 98.82%Forma y color:SolidPeso molecular:550.53Dabrafenib
CAS:Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.Fórmula:C23H20F3N5O2S2Pureza:99.62% - >99.99%Forma y color:SolidPeso molecular:519.562-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS:Pro-neurotropic drug boosts brain acetylcholine synthesis and release, inhibits breakdown.Fórmula:C17H16O5Pureza:98.68%Forma y color:SolidPeso molecular:300.31TAO Kinase inhibitor 1
CAS:TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death.Fórmula:C25H24N2O2Pureza:99.74%Forma y color:SolidPeso molecular:384.47Sotorasib
CAS:<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Fórmula:C30H30F2N6O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:560.594NG25 trihydrochloride
CAS:NG25 trihydrochloride: kinase inhibitor for MAP4K2, TAK1, Src, LYN, Abl, CSK, FER, p38α; blocks TNF-α signals; impedes IFN secretion; anti-cancer properties.Fórmula:C29H33Cl3F3N5O2Forma y color:SolidPeso molecular:646.96JIP-1 (153-163) acetate(438567-88-5 free base)
JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.Fórmula:C63H108N20O16Pureza:92.89%Forma y color:SolidPeso molecular:1401.65Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Forma y color:SolidPeso molecular:471.46Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Fórmula:C23H18ClF2N3O3SPureza:98.53% - 99.36%Forma y color:SolidPeso molecular:489.92SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Fórmula:C18H13N7SPureza:99% - >99.99%Forma y color:SolidPeso molecular:359.41BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Fórmula:C27H28N4O2Pureza:97.84%Forma y color:SolidPeso molecular:440.54AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Fórmula:C28H21N7OSPureza:98.4% - 99.51%Forma y color:SolidPeso molecular:503.58SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Fórmula:C20H21FN4O2Pureza:99.42% - 99.81%Forma y color:SolidPeso molecular:368.4sodium lauroyl-α-hydroxyethyl sulfonate
CAS:Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.Fórmula:C14H27NaO5SPureza:≥98% - ≥98%Forma y color:SolidPeso molecular:330.41APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Fórmula:C23H21N3O3Forma y color:SolidPeso molecular:387.43SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Fórmula:C24H28N2O9SPureza:95.65%Forma y color:SolidPeso molecular:520.55HPK1-IN-34
CAS:HPK1-IN-34 (Compound 143) is an inhibitor of HPK1 (Haematopoietic progenitor kinase 1) with an IC₅₀ < 0.1 μM, suitable for cancer and immunology research.Fórmula:C25H28N4O2SPureza:99.39%Forma y color:SolidPeso molecular:448.58B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Fórmula:C29H24F3N5OPureza:97.22% - 99.27%Forma y color:SolidPeso molecular:515.53CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Fórmula:C24H15F2N3Pureza:98.79%Forma y color:SolidPeso molecular:383.39PF-06260933
CAS:<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Fórmula:C16H13ClN4Pureza:99.63% - 99.97%Forma y color:SolidPeso molecular:296.75(E/Z)-BIX02188
CAS:BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.Fórmula:C25H24N4O2Pureza:97.39% - 98.38%Forma y color:SolidPeso molecular:412.48DB07268
CAS:<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Forma y color:SolidPeso molecular:321.33Cephradine sodium
CAS:Cephradine sodium, a semi-synthetic cephalosporin antibiotic, disrupts bacterial cell wall synthesis, causing lysis.Fórmula:C16H18N3NaO4SForma y color:SolidPeso molecular:371.39Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Fórmula:C24H27ClN2O3Pureza:99.23%Forma y color:SolidPeso molecular:426.94Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Forma y color:SolidPeso molecular:411.38p-Cresyl sulfate potassium
CAS:p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanineFórmula:C7H7KO4SPureza:99.38% - 99.90%Forma y color:SolidPeso molecular:226.29BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Fórmula:C22H26N6O2Pureza:98.11%Forma y color:SolidPeso molecular:406.48Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Fórmula:C23H24ClN3O3Pureza:97.98%Forma y color:SolidPeso molecular:425.91ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Forma y color:SolidPeso molecular:385.5SR-318
CAS:<p>SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).</p>Fórmula:C27H33N5O2Pureza:99.74%Forma y color:SolidPeso molecular:459.58KO-947
CAS:<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Fórmula:C21H17N5OPureza:97.84%Forma y color:SolidPeso molecular:355.39Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Fórmula:C19H20O6Pureza:99.6% - 99.71%Forma y color:SolidPeso molecular:344.36Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Fórmula:C25H17ClF4N6O3SForma y color:SolidPeso molecular:592.95CMPD1
CAS:CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).Fórmula:C22H20FNO2Pureza:99.8%Forma y color:SolidPeso molecular:349.4JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Forma y color:SolidPeso molecular:507.59ARS-1620
CAS:<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Fórmula:C21H17ClF2N4O2Pureza:98.86%Forma y color:SolidPeso molecular:430.84K-Ras-IN-1
CAS:K-Ras-IN-1 is a K-Ras inhibitor.Fórmula:C11H13NOSPureza:98.72%Forma y color:SolidPeso molecular:207.29Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Fórmula:C19H20F3IN2O5SPureza:99.85% - >99.99%Forma y color:SolidPeso molecular:572.34N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Fórmula:C11H15NOPureza:99.46% - 99.84%Forma y color:SolidPeso molecular:177.246H05 (TFA)
CAS:6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Fórmula:C22H31ClF3N3O4S3Pureza:98.83%Forma y color:SolidPeso molecular:590.14JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Fórmula:C28H27N7O2Pureza:98.02% - 99.53%Forma y color:SolidPeso molecular:493.56SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Fórmula:C27H27N5O2Pureza:95.42% - 99.06%Forma y color:SolidPeso molecular:453.54Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Fórmula:C15H16ClFIN3O3Forma y color:SolidPeso molecular:467.66HPK1-IN-7
CAS:<p>HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).</p>Fórmula:C24H22N6O4Pureza:99.79%Forma y color:SolidPeso molecular:458.47Talmapimod
CAS:Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:513AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Fórmula:C20H16N6SPureza:98% - 99.02%Forma y color:SolidPeso molecular:372.45Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Forma y color:SolidPeso molecular:433.331-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Fórmula:C9H10O2SPureza:99.48%Forma y color:SolidPeso molecular:182.24Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Fórmula:C22H27N7O2SPureza:99.57% - >99.99%Forma y color:SolidPeso molecular:453.56MK2-IN-3
CAS:MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.Fórmula:C21H16N4OPureza:99.01%Forma y color:SolidPeso molecular:340.38I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Forma y color:SolidPeso molecular:482.92ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Forma y color:SolidPeso molecular:473.93SM-7368
CAS:<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Fórmula:C10H5ClN4O5SPureza:99.64%Forma y color:SolidPeso molecular:328.69K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Forma y color:SolidPeso molecular:513.78BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Fórmula:C25H28N4O2SPureza:97.16%Forma y color:SolidPeso molecular:448.58TAK-715
CAS:<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Fórmula:C24H21N3OSPureza:99.83%Forma y color:SolidPeso molecular:399.51ML-098
CAS:ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Fórmula:C19H19NO3Pureza:99.06% - 99.23%Forma y color:SolidPeso molecular:309.36KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Fórmula:C110H186N44O27S2Pureza:98.94%Forma y color:SolidPeso molecular:2621.06
