MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 886 productos de "MAPK"
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KRpep-2d
CAS:KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Fórmula:C109H183N43O25S2Forma y color:SolidPeso molecular:2560.02JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Fórmula:C32H30FN7O3Forma y color:SolidPeso molecular:579.62SCH772984 HCl
<p>SCH772984 HCl selectively inhibits ERK1/2, acts like type I/II kinase inhibitors, and is potent at 4/1 nM IC50s in certain mutated tumor cells.</p>Fórmula:C33H34ClN9O2Pureza:98%Forma y color:SolidPeso molecular:624.14MLKL-IN-2
CAS:<p>MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.</p>Fórmula:C26H25N5OPureza:98.30%Forma y color:SolidPeso molecular:423.51JNK-IN-12
<p>JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptide</p>Fórmula:C56H82N16O7Pureza:98%Forma y color:SolidPeso molecular:1091.35JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Fórmula:C27H31N5O4SPureza:98%Forma y color:SolidPeso molecular:521.63Tagarafdeg
CAS:<p>Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.</p>Fórmula:C45H49F2N11O9SPureza:＞99.99%Forma y color:SolidPeso molecular:958StRIP16
<p>Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.</p>Forma y color:SolidGAGGVGKSAL
CAS:<p>GAGGVGKSAL, a wild-type KRAS G12D 10mer peptide, serves as an immunogenic neoantigen in cancer immunotherapy research [1].</p>Fórmula:C34H61N11O12Forma y color:SolidPeso molecular:815.91KRAS inhibitor-24
CAS:<p>KRAS inhibitor-24 (compound 115c), a pyrido-pyridine class KRAS inhibitor, exhibits potent activity against KRas G12V, KRas WT, and KRas G12R, with IC50 values all below 100 nM.</p>Fórmula:C33H39ClF2N6O3Forma y color:SolidPeso molecular:641.15PD 198306
CAS:<p>PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.</p>Fórmula:C18H16F3IN2O2Pureza:99.66%Forma y color:SolidPeso molecular:476.23PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Fórmula:C54H69N11O6SPureza:98%Forma y color:SolidPeso molecular:1000.26PROTAC SOS1 degrader-5
CAS:<p>PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].</p>Fórmula:C45H51F3N8O7Forma y color:SolidPeso molecular:872.93MEK1/2-IN-3
<p>MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.</p>Fórmula:C28H23F3IN3O4Forma y color:SolidPeso molecular:649.4G12 TFA
<p>G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.</p>Fórmula:C54H96F3N15O17Peso molecular:1283.70607WYE-687
CAS:<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Fórmula:C28H32N8O3Pureza:99.93%Forma y color:SolidPeso molecular:528.61Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Fórmula:C46H60N8O5SForma y color:SolidPeso molecular:837.08Anti-osteoporosis agent-8
<p>Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.</p>Fórmula:C18H19F3N2O2SePeso molecular:432.05638Ro-3201195
CAS:<p>Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.</p>Fórmula:C19H18FN3O4Pureza:99.15%Forma y color:SolidPeso molecular:371.36MNK-IN-4
<p>MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor used in treating acute spleen injury related to sepsis.</p>Fórmula:C15H17N5Peso molecular:267.1484NUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Forma y color:Odour Solidp38α inhibitor 5
CAS:<p>The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.</p>Fórmula:C26H23BrF2N2O3Forma y color:SolidPeso molecular:529.37IQ-1S
CAS:<p>IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.</p>Fórmula:C15H8N3NaOForma y color:SolidPeso molecular:269.23HS220
CAS:<p>HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.</p>Fórmula:C18H17N3O3Pureza:99.39%Forma y color:SoildPeso molecular:323.35Pan-RAS-IN-5
<p>Pan-RAS-IN-5 (compound 7A) is a molecular glue that facilitates the formation of a ternary complex with cyclophilin A (CYPA) and RAS(ON) protein. This complex inhibits the binding of RAF downstream of RAS, demonstrating antitumor activity.</p>Fórmula:C45H58N8O5SPeso molecular:822.42509QL-X-138 HCl
<p>QL-X-138 HCl is a BTK/MNK dual kinase inhibitor with anticancer activity and anti-dengue virus 2 activity that inhibits BTK, MNK1, and MNK2 kinases.</p>Fórmula:C25H20ClN5O2Pureza:99.25%Forma y color:SoildPeso molecular:457.91KRAS G12D inhibitor 20
KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor with antitumor activity.Fórmula:C18H26N6OPeso molecular:342.21681KRAS G12D inhibitor 15
CAS:<p>Potent KRAS G12D inhibitor 15 targets cancer, potential for disease research. (WO2022042630A1, compound 243)</p>Fórmula:C53H71F2N7O5Forma y color:SolidPeso molecular:924.17YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Pureza:98%Forma y color:Odour SolidVem-L-Cy5
<p>Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAF</p>Fórmula:C63H68F5N7O9SPureza:98%Forma y color:SolidPeso molecular:1194.31JTP10-△-R9 TFA
<p>JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.</p>Fórmula:C119H214F3N53O26Pureza:98%Forma y color:SolidPeso molecular:2860.31ZINC05007751
CAS:<p>ZINC05007751 inhibits NEK6 (IC50=3.4μM), selective for NEK1/6, inactive on NEK2/7/9.</p>Fórmula:C18H12N2O3Pureza:99.7%Forma y color:SolidPeso molecular:304.3PROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Fórmula:C46H55F2N9O9SForma y color:SolidPeso molecular:948.05KRASG12C IN-2
<p>KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].</p>Forma y color:SolidScio-323
CAS:<p>Scio-323是一种可口服的 p38丝裂原活化蛋白（MAPK）激酶抑制剂。</p>Fórmula:C27H30FN3O4Pureza:99.58%Forma y color:SolidPeso molecular:479.54JNK3 inhibitor-7
<p>Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.</p>Fórmula:C32H31N7O3Forma y color:SolidPeso molecular:561.63JTP10-△-TATi TFA
<p>JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.</p>Fórmula:C120H213F3N48O28Pureza:98%Forma y color:SolidPeso molecular:2833.28KP-14
<p>KP-14 is a PROTAC specifically designed to target KRAS.</p>Fórmula:C41H41Cl3N6O8Forma y color:SolidPeso molecular:852.16KRAS G12D inhibitor 3 TFA
CAS:<p>KRAS G12D Inhibitor 3 TFA, exhibiting an inhibitory concentration (IC50) of less than 500 nM, is effective as an antitumor agent.</p>Fórmula:C36H32ClF6N5O4Forma y color:SolidPeso molecular:748.11CHPG hydrochloride
<p>CHPG hydrochloride is a selective agonist of mGluR5.</p>Fórmula:C8H9Cl2NO3Pureza:98.1%Forma y color:SoildPeso molecular:238.07KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Fórmula:C32H37ClN8O2Forma y color:SolidPeso molecular:601.15HPK1-IN-53
<p>HPK1-IN-53 (compound 3a) is the most potent inhibitor of HPK1, exhibiting an IC50 value of 48 nM.</p>Forma y color:Odour SolidJNK-IN-18
<p>JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).</p>Forma y color:Odour SolidPROTAC K-Ras Degrader-4
CAS:<p>PROTAC K-Ras Degrader-4 is a molecule designed to selectively degrade oncogenic K-Ras mutants, a novel strategy for cancer research.</p>Fórmula:C50H60N12O6S2Forma y color:SoildPeso molecular:989.22Cobimetinib (R-enantiomer)
CAS:<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Fórmula:C21H21F3IN3O2Pureza:98%Forma y color:SolidPeso molecular:531.318PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Fórmula:C53H65ClN8O7SPureza:98%Forma y color:SolidPeso molecular:993.65MEK ligand-2
CAS:<p>MEK ligand-2, a ligand for the target protein for PROTAC (Ligand for Target Protein for PROTAC), functions as an inhibitor for both MEK1 and MEK2. This compound plays a crucial role in MS934, which is a VHL-recruiting MEK1/2 PROTAC degrader.</p>Fórmula:C13H8F3IN2O2Forma y color:SolidPeso molecular:408.12RTIL 13
CAS:<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Fórmula:C30H55BrN2O3Forma y color:SolidPeso molecular:571.685KRpep-2d TFA
<p>KRpep-2d (TFA) is a potent inhibitor of K-Ras, effectively hindering the proliferation of K-Ras-driven cancer cells, thereby serving as a valuable asset for</p>Fórmula:C110H183F3N44O27S2Forma y color:SolidPeso molecular:2675.03Enniatin B1
CAS:<p>Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.</p>Fórmula:C34H59N3O9Pureza:98%Forma y color:SolidPeso molecular:653.858LC-2
CAS:<p>LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a</p>Fórmula:C59H71ClFN11O7SPureza:98%Forma y color:SolidPeso molecular:1132.78Tunlametinib
CAS:<p>Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.</p>Fórmula:C16H12F2IN3O3SPureza:98.72%Forma y color:SolidPeso molecular:491.25Anti-ERK2 Antibody (5V598)
<p>Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.</p>Forma y color:Odour LiquidAnti-ERK2 Antibody (4F551)
<p>Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.</p>Forma y color:Odour LiquidAnti-ERK2 Antibody (9C922)
<p>Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.</p>Forma y color:Odour LiquidRAS GTPase inhibitor 1
CAS:<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Fórmula:C27H28ClF4N5O2Pureza:98.43%Forma y color:SolidPeso molecular:565.99TRPM4 inhibitor 8
CAS:<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Fórmula:C11H17BrN2Pureza:97%Forma y color:SolidPeso molecular:257.17S6K1-IN-DG2
CAS:<p>S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.</p>Fórmula:C16H17BrN6OPureza:99.25%Forma y color:SolidPeso molecular:389.25Enniatin B
CAS:<p>Enniatins B decreases the activation of ERK (p44/p42).</p>Fórmula:C33H57N3O9Pureza:98%Forma y color:SolidPeso molecular:639.831EM127
CAS:<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Fórmula:C14H18ClN3O3Pureza:97.61%Forma y color:SolidPeso molecular:311.76TAK1-IN-3
CAS:<p>TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.</p>Fórmula:C16H19N3O2SPureza:98.88%Forma y color:SolidPeso molecular:317.41JH295
CAS:<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Fórmula:C18H16N4O2Forma y color:SolidPeso molecular:320.352TAK-580
CAS:<p>TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.</p>Fórmula:C17H12Cl2F3N7O2SPureza:99.25% - 99.77%Forma y color:SolidPeso molecular:506.29PROTAC BRAF-V600E degrader-1
CAS:<p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>Fórmula:C48H54F2N10O10SPureza:99.43%Forma y color:SolidPeso molecular:1001.07Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Fórmula:C42H72O14Pureza:99.42% - 99.65%Forma y color:SolidPeso molecular:801.01LY-2584702 free base
CAS:<p>LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).</p>Fórmula:C21H19F4N7Pureza:98.72% - 99.51%Forma y color:SolidPeso molecular:445.42A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Fórmula:C22H24Cl2N4OPureza:94.66%Forma y color:SolidPeso molecular:431.36NG25
CAS:<p>NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.</p>Fórmula:C29H30F3N5O2Pureza:98.32% - ≥95%Forma y color:SolidPeso molecular:537.58Isoliquiritin apioside
CAS:<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Fórmula:C26H30O13Pureza:98.84% - 99.27%Forma y color:SolidPeso molecular:550.51PH-797804
CAS:<p>PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.</p>Fórmula:C22H19BrF2N2O3Pureza:97.90% - 98.27%Forma y color:SolidPeso molecular:477.3K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Forma y color:SolidPeso molecular:405.34LY-364947
CAS:<p>LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.</p>Fórmula:C17H12N4Pureza:99.41% - 99.96%Forma y color:SolidPeso molecular:272.3DMX-5804
CAS:<p>DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice</p>Fórmula:C21H19N3O3Pureza:99.34%Forma y color:SolidPeso molecular:361.39methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS:<p>methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.</p>Fórmula:C13H13NO5Pureza:97.69%Forma y color:SolidPeso molecular:263.25R1487
CAS:<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Fórmula:C19H18F2N4O3Pureza:99.77%Forma y color:SolidPeso molecular:388.37PF-06260933 HCl
CAS:<p>PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.</p>Fórmula:C16H15Cl3N4Forma y color:SolidPeso molecular:369.68AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Fórmula:C16H17FIN3O4Pureza:98.72%Forma y color:SolidPeso molecular:461.23GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Fórmula:C16H11N5O2SPureza:98.86%Forma y color:SolidPeso molecular:337.36Kobe2602
CAS:<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Fórmula:C14H9F4N5O4SPureza:98.36% - 99.39%Forma y color:SolidPeso molecular:419.31IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Fórmula:C20H11N3O3Pureza:≥98%Forma y color:SolidPeso molecular:341.32Belvarafenib
CAS:<p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>Fórmula:C23H16ClFN6OSPureza:98% - 99.65%Forma y color:SolidPeso molecular:478.93Ravoxertinib
CAS:<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Fórmula:C21H18ClFN6O2Pureza:98% - 99.87%Forma y color:SolidPeso molecular:440.86Agerafenib
CAS:<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Fórmula:C24H22F3N5O5Pureza:95.78% - 99.23%Forma y color:SolidPeso molecular:517.46Vemurafenib
CAS:<p>Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.</p>Fórmula:C23H18ClF2N3O3SPureza:98% - 99.65%Forma y color:SolidPeso molecular:489.92B-Raf IN 11
CAS:<p>B-Raf IN 11 is a novel selective inhibitor.</p>Fórmula:C17H14BrF2N3O3SPureza:99.947%Forma y color:SolidPeso molecular:458.28Regorafenib Hydrochloride
CAS:<p>Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.</p>Fórmula:C21H16Cl2F4N4O3Pureza:99.56%Forma y color:SolidPeso molecular:519.28LY-2584702 tosylate salt
CAS:<p>LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.</p>Fórmula:C28H27F4N7O3SPureza:98.5% - 98.51%Forma y color:SolidPeso molecular:617.62Dabrafenib Mesylate
CAS:<p>Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).</p>Fórmula:C24H24F3N5O5S3Pureza:99.45% - 99.82%Forma y color:SolidPeso molecular:615.67Bohemine
CAS:<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Fórmula:C18H24N6OPureza:99.09% - 99.53%Forma y color:SolidPeso molecular:340.42MW-150
CAS:<p>MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.</p>Fórmula:C24H23N5Pureza:97.35% - 99.27%Forma y color:SolidPeso molecular:381.47RAF709
CAS:<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Fórmula:C28H29F3N4O4Pureza:99.28% - 99.8%Forma y color:SolidPeso molecular:542.55Maohuoside A
CAS:<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Fórmula:C27H32O12Pureza:98.91% - 99.57%Forma y color:SolidPeso molecular:548.54GNE-495
CAS:<p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>Fórmula:C22H20FN5O2Pureza:99.22% - 99.57%Forma y color:SolidPeso molecular:405.42APS-2-79 hydrochloride
CAS:<p>APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.</p>Fórmula:C23H21N3O3·HClPureza:98.64% - 99.55%Forma y color:SolidPeso molecular:423.89AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Fórmula:C28H21N7OSPureza:98.4% - 99.51%Forma y color:SolidPeso molecular:503.58Raf inhibitor 1 dihydrochloride
CAS:<p>Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.</p>Fórmula:C26H19ClN8HClPureza:98.19% - 99.54%Forma y color:SolidPeso molecular:551.86NVP-BHG712
CAS:<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Fórmula:C26H20F3N7OPureza:97.32% - 98.63%Forma y color:SolidPeso molecular:503.48SLV-2436
CAS:<p>SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).</p>Fórmula:C19H15ClN4OPureza:98.56%Forma y color:SolidPeso molecular:350.8ASK1-IN-1
CAS:<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Fórmula:C19H19N9O2Pureza:99.92%Forma y color:SolidPeso molecular:405.41Necrosulfonamide
CAS:<p>Necrosulfonamide ((E)-Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. High-Quality, Low-Cost!</p>Fórmula:C18H15N5O6S2Pureza:98.85% - 99.49%Forma y color:SolidPeso molecular:461.47ASP2453
CAS:<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Fórmula:C40H48F3N7O4Pureza:99.71%Forma y color:SolidPeso molecular:747.85PLX-4720
CAS:<p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>Fórmula:C17H14ClF2N3O3SPureza:97.78% - 99.83%Forma y color:SolidPeso molecular:413.83ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Forma y color:SolidPeso molecular:473.93ERK5-IN-2
CAS:<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Fórmula:C17H11BrFN3O2Pureza:99.01%Forma y color:SolidPeso molecular:388.19SKF-86002
CAS:<p>SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).</p>Fórmula:C16H12FN3SPureza:98% - 99.85%Forma y color:SolidPeso molecular:297.35BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Fórmula:C25H28N4O2SPureza:97.16%Forma y color:SolidPeso molecular:448.58(S)-AMG-510
CAS:<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Fórmula:C30H30F2N6O3Pureza:99.05% - 99.76%Forma y color:SolidPeso molecular:560.594BI-D1870
CAS:<p>BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.</p>Fórmula:C19H23F2N5O2Pureza:98.51% - 99.43%Forma y color:SolidPeso molecular:391.42Locostatin
CAS:<p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>Fórmula:C14H15NO3Pureza:97.13%Forma y color:SolidPeso molecular:245.27SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Fórmula:C20H21FN4O2Pureza:99.42% - 99.81%Forma y color:SolidPeso molecular:368.4Pimasertib
CAS:<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Fórmula:C15H15FIN3O3Pureza:98.25% - 99.57%Forma y color:SolidPeso molecular:431.2Skepinone-L
CAS:<p>Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.</p>Fórmula:C24H21F2NO4Pureza:99.56% - >99.99%Forma y color:SolidPeso molecular:425.42LM22B-10
CAS:<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Fórmula:C27H33ClN2O4Pureza:98.18%Forma y color:SolidPeso molecular:485.01Tomivosertib
CAS:<p>Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.</p>Fórmula:C17H20N6O2Pureza:97.34% - 99.72%Forma y color:SolidPeso molecular:340.38APS6-45
CAS:<p>APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.</p>Fórmula:C23H16F8N4O3Pureza:99.39%Forma y color:SolidPeso molecular:548.39GW 284543 hydrochloride
CAS:<p>GW 284543 hydrochloride is a selective inhibitor of MEK5 .</p>Fórmula:C23H21ClN2O3Pureza:99.73%Forma y color:SolidPeso molecular:408.87CC-401 Hydrochloride
CAS:<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Fórmula:C22H25ClN6OPureza:99.71% - ≥95%Forma y color:SolidPeso molecular:424.93PF-4708671
CAS:<p>PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).</p>Fórmula:C19H21F3N6Pureza:99.48% - 99.67%Forma y color:SolidPeso molecular:390.41BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Forma y color:SolidPeso molecular:379.37PLX8394
CAS:<p>Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.</p>Fórmula:C25H21F3N6O3SPureza:98.75% - >99.99%Forma y color:SolidPeso molecular:542.53Sotorasib
CAS:<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Fórmula:C30H30F2N6O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:560.594S6K-18
CAS:<p>S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.</p>Fórmula:C17H18N4O3SPureza:98.99%Forma y color:SolidPeso molecular:358.41Binimetinib
CAS:<p>Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C17H15BrF2N4O3Pureza:98.03% - >99.99%Forma y color:SolidPeso molecular:441.23SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Fórmula:C18H13N7SPureza:99% - >99.99%Forma y color:SolidPeso molecular:359.41SB 242235
CAS:<p>SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.</p>Fórmula:C19H20FN5OPureza:99.13% - 99.68%Forma y color:SolidPeso molecular:353.39TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Forma y color:SolidPeso molecular:351.32Tizoxanide
CAS:<p>Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.</p>Fórmula:C10H7N3O4SPureza:98.89% - 99.28%Forma y color:SolidPeso molecular:265.25Losmapimod
CAS:<p>Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).</p>Fórmula:C22H26FN3O2Pureza:98.35% - 99.89%Forma y color:SolidPeso molecular:383.46Dabrafenib
CAS:<p>Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.</p>Fórmula:C23H20F3N5O2S2Pureza:99.62% - >99.99%Forma y color:SolidPeso molecular:519.56BIX02189
CAS:<p>BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).</p>Fórmula:C27H28N4O2Pureza:97.84%Forma y color:SolidPeso molecular:440.54Theaflavin 3,3′-digallate
CAS:<p>Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer</p>Fórmula:C43H32O20Pureza:98.71% - 99.86%Forma y color:SolidPeso molecular:868.7Raf inhibitor 2
CAS:<p>Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.</p>Fórmula:C15H8Br2ClNO2Pureza:98.53%Forma y color:SolidPeso molecular:429.49Ro 5126766
CAS:<p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Forma y color:SolidPeso molecular:471.46SCH54292
CAS:<p>SCH-54292 is a GDP exchange inhibitor.</p>Fórmula:C24H28N2O9SPureza:95.65%Forma y color:SolidPeso molecular:520.55BAY885
CAS:<p>BAY885 is a new ERK5 inhibitor.</p>Fórmula:C25H28F3N7O2Pureza:99.83%Forma y color:SolidPeso molecular:515.53NG25 trihydrochloride
CAS:<p>NG25 trihydrochloride: kinase inhibitor for MAP4K2, TAK1, Src, LYN, Abl, CSK, FER, p38α; blocks TNF-α signals; impedes IFN secretion; anti-cancer properties.</p>Fórmula:C29H33Cl3F3N5O2Forma y color:SolidPeso molecular:646.96SL327
CAS:<p>SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.</p>Fórmula:C16H12F3N3SPureza:97.98% - >99.99%Forma y color:SolidPeso molecular:335.35LY3009120
CAS:<p>LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.</p>Fórmula:C23H29FN6OPureza:96.96% - ≥95%Forma y color:SolidPeso molecular:424.51SR-318
CAS:<p>SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).</p>Fórmula:C27H33N5O2Pureza:99.74%Forma y color:SolidPeso molecular:459.58TAO Kinase inhibitor 1
CAS:TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death.Fórmula:C25H24N2O2Pureza:99.74%Forma y color:SolidPeso molecular:384.47A-443654
CAS:<p>A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).</p>Fórmula:C24H23N5OPureza:98.04% - 99.51%Forma y color:SolidPeso molecular:397.47JIP-1 (153-163) acetate(438567-88-5 free base)
<p>JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.</p>Fórmula:C63H108N20O16Pureza:92.89%Forma y color:SolidPeso molecular:1401.65TAK-632
CAS:<p>TAK-632 is a potent pan-Raf inhibitor.</p>Fórmula:C27H18F4N4O3SPureza:98% - 99.5%Forma y color:SolidPeso molecular:554.522-(4-methoxyphenyl)-2-oxoethyl 2-hydroxy-5-methylbenzoate
CAS:<p>Pro-neurotropic drug boosts brain acetylcholine synthesis and release, inhibits breakdown.</p>Fórmula:C17H16O5Pureza:98.68%Forma y color:SolidPeso molecular:300.31Pluripotin
CAS:<p>Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and</p>Fórmula:C27H25F3N8O2Pureza:98.77% - 98.82%Forma y color:SolidPeso molecular:550.53SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C33H33N9O2Pureza:97.565% - 98.75%Forma y color:SolidPeso molecular:587.67TAK-715
CAS:<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Fórmula:C24H21N3OSPureza:99.83%Forma y color:SolidPeso molecular:399.51APS-2-79
CAS:<p>APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.</p>Fórmula:C23H21N3O3Forma y color:SolidPeso molecular:387.43Acumapimod
CAS:<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Fórmula:C22H19N5O2Pureza:≥95%Forma y color:SolidPeso molecular:385.42KO-947
CAS:<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Fórmula:C21H17N5OPureza:97.84%Forma y color:SolidPeso molecular:355.39BMS-582949 hydrochloride
CAS:<p>The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).</p>Fórmula:C22H27ClN6O2Pureza:97.57% - 98.75%Forma y color:SolidPeso molecular:442.95sodium lauroyl-α-hydroxyethyl sulfonate
CAS:<p>Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.</p>Fórmula:C14H27NaO5SPureza:≥98% - ≥98%Forma y color:SolidPeso molecular:330.41DB07268
CAS:<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Forma y color:SolidPeso molecular:321.33p-Cresyl sulfate potassium
CAS:<p>p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanine</p>Fórmula:C7H7KO4SPureza:99.38%Forma y color:SolidPeso molecular:226.29XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Forma y color:SolidPeso molecular:638.8Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Fórmula:C24H27ClN2O3Pureza:99.23%Forma y color:SolidPeso molecular:426.94Rasarfin
CAS:<p>Rasarfin inhibits Ras and ARF6.</p>Fórmula:C23H24ClN3O3Pureza:97.98%Forma y color:SolidPeso molecular:425.91BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Fórmula:C22H26N6O2Pureza:98.11%Forma y color:SolidPeso molecular:406.48CAY10404
CAS:<p>CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.</p>Fórmula:C17H12F3NO3SPureza:99.02%Forma y color:SolidPeso molecular:367.34K-Ras(G12C) inhibitor 9
CAS:<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Forma y color:SolidPeso molecular:513.78SB-590885
CAS:<p>SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).</p>Fórmula:C27H27N5O2Pureza:95.42% - 99.06%Forma y color:SolidPeso molecular:453.54ZT-12-037-01
CAS:<p>Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).</p>Fórmula:C21H31N5O2Pureza:99.56%Forma y color:SolidPeso molecular:385.5JNK-IN-7
CAS:<p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>Fórmula:C28H27N7O2Pureza:98.02% - 99.53%Forma y color:SolidPeso molecular:493.56PF-06260933
CAS:<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Fórmula:C16H13ClN4Pureza:99.63% - 99.97%Forma y color:SolidPeso molecular:296.75CK1-IN-1
CAS:<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Fórmula:C24H15F2N3Pureza:98.79%Forma y color:SolidPeso molecular:383.39N-tert-butyl-α-Phenylnitrone
CAS:<p>N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.</p>Fórmula:C11H15NOPureza:99.46% - 99.84%Forma y color:SolidPeso molecular:177.24B-Raf IN 1
CAS:<p>B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.</p>Fórmula:C29H24F3N5OPureza:97.22% - 99.27%Forma y color:SolidPeso molecular:515.53ERK5-IN-1
CAS:<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Fórmula:C25H29N7O2Pureza:97.70%Forma y color:SolidPeso molecular:459.54Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Forma y color:SolidPeso molecular:433.33I-49 free base
<p>I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel</p>Fórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Forma y color:SolidPeso molecular:482.92JNK Inhibitor VIII
CAS:<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Fórmula:C18H20N4O4Pureza:98.93%Forma y color:SolidPeso molecular:356.38ARS-1620
CAS:<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Fórmula:C21H17ClF2N4O2Pureza:98.86%Forma y color:SolidPeso molecular:430.84Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Fórmula:C19H9Cl2F2N3OSPureza:97.88% - 99.75%Forma y color:SolidPeso molecular:436.26Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Fórmula:C25H17ClF4N6O3SForma y color:SolidPeso molecular:592.95K-Ras-IN-1
CAS:<p>K-Ras-IN-1 is a K-Ras inhibitor.</p>Fórmula:C11H13NOSPureza:98.72%Forma y color:SolidPeso molecular:207.29JNK-IN-8
CAS:<p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Forma y color:SolidPeso molecular:507.59SUN11602
CAS:<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Fórmula:C26H37N5O2Pureza:99.36%Forma y color:SolidPeso molecular:451.6KRPEP-2D acetate
<p>KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.</p>Fórmula:C110H186N44O27S2Pureza:98.94%Forma y color:SolidPeso molecular:2621.06VX-11e
CAS:<p>VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.</p>Fórmula:C24H20Cl2FN5O2Pureza:98.92% - ≥98%Forma y color:SolidPeso molecular:500.35Plx-4032
CAS:<p>Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.</p>Fórmula:C23H18ClF2N3O3SPureza:98.53% - 99.36%Forma y color:SolidPeso molecular:489.92Refametinib
CAS:<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Fórmula:C19H20F3IN2O5SPureza:99.53% - >99.99%Forma y color:SolidPeso molecular:572.34TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Fórmula:C20H13F2N3Pureza:99.35% - 99.79%Forma y color:SolidPeso molecular:333.33SD-169
CAS:<p>SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.</p>Fórmula:C9H8N2OPureza:98.6%Forma y color:SolidPeso molecular:160.17SM-7368
CAS:<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Fórmula:C10H5ClN4O5SPureza:99.64%Forma y color:SolidPeso molecular:328.696H05 (TFA)
CAS:<p>6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.</p>Fórmula:C22H31ClF3N3O4S3Pureza:98.83%Forma y color:SolidPeso molecular:590.14ML-098
CAS:<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Fórmula:C19H19NO3Pureza:99.06% - 99.23%Forma y color:SolidPeso molecular:309.36MK2-IN-3
CAS:<p>MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.</p>Fórmula:C21H16N4OPureza:99.01%Forma y color:SolidPeso molecular:340.381-(4-methansulfinylphenyl)ethanone
CAS:<p>The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.</p>Fórmula:C9H10O2SPureza:99.48%Forma y color:SolidPeso molecular:182.24CCT196969
CAS:<p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>Fórmula:C27H24FN7O3Pureza:98.93% - 99.65%Forma y color:SolidPeso molecular:513.52Cefotetan
CAS:<p>Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.</p>Fórmula:C17H17N7O8S4Pureza:95.72% - 99.38%Forma y color:SolidPeso molecular:575.62SD 0006
CAS:<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Fórmula:C20H20ClN5O2Pureza:98.32%Forma y color:SolidPeso molecular:397.86CMPD1
CAS:<p>CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).</p>Fórmula:C22H20FNO2Pureza:99.8%Forma y color:SolidPeso molecular:349.4Talmapimod
CAS:<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:513AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Forma y color:SolidPeso molecular:485.581588-A4
CAS:<p>1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.</p>Fórmula:C17H19BrClFN4O2Pureza:98.59%Forma y color:SolidPeso molecular:445.71GSK-114
CAS:<p>GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.</p>Fórmula:C19H23N5O4SPureza:99.51%Forma y color:SolidPeso molecular:417.48Varenicline Tartrate
CAS:<p>Varenicline Tartrate (CP 526555-18) is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist.</p>Fórmula:C13H13N3·C4H6O6Pureza:98.23% - 98.32%Forma y color:Tan SolidPeso molecular:361.35Encorafenib
CAS:<p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>Fórmula:C22H27ClFN7O4SPureza:99.51% - 99.83%Forma y color:SolidPeso molecular:540.01AG126
CAS:<p>AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.</p>Fórmula:C10H5N3O3Pureza:97.35%Forma y color:SolidPeso molecular:215.16D-JNKI-1 acetate
<p>D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.</p>Fórmula:C166H290N66O42Pureza:99.48%Forma y color:SolidPeso molecular:3882.5
