MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 886 productos de "MAPK"
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BRAFV600E-IN-1
<p>BRAFV600E-IN-1 (compound 9S) is an inhibitor of BRAF. It exhibits significant apoptotic effects in cell lines expressing mutant KRAS and cancer cells harboring BRAFV600E.</p>Fórmula:C23H16Cl3N5O4Forma y color:SolidPeso molecular:532.76Mitogen-activated protein kinase 1
CAS:<p>Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.</p>Pureza:98%Forma y color:SolidSetidegrasib
CAS:<p>KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.</p>Fórmula:C60H65FN12O7SForma y color:SolidPeso molecular:1117.3KRASG12C IN-2
<p>KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].</p>Forma y color:SolidKRAS inhibitor-25
CAS:<p>KRAS inhibitor-25 (compound 151a), a pyrido[2,3-d]pyrimidine derivative, effectively inhibits KRas G12V, KRas WT, and KRas G12R with IC50 values all below 100 nM.</p>Fórmula:C32H38ClF2N5O3Forma y color:SolidPeso molecular:614.13Debromohymenialdisine
CAS:<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Fórmula:C11H11N5O2Forma y color:SolidPeso molecular:245.242Vacquinol-1
CAS:<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Fórmula:C21H21ClN2OPureza:98.67%Forma y color:SolidPeso molecular:352.86Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidTUS-007
CAS:<p>TUS-007, a non-proteasome inhibiting CANDDY, is an oral KRAS G12D/V degrader for cell-free chemical knockdown and tumor suppression.</p>Fórmula:C44H54Cl2N8O5Forma y color:SolidPeso molecular:845.86PROTAC KRAS G12C degrader-2
CAS:<p>PROTAC KRAS G12C degrader-2 (compound 432) acts as a bifunctional modulator, enhancing the hydrolysis of K-Ras protein. One end of this compound features a cereblon inhibitor of apoptosis proteins (IAP), while the other end contains a moiety that binds to KRAS [1].</p>Fórmula:C51H53ClFN9O7Forma y color:SolidPeso molecular:958.47OVA-E1 peptide
CAS:<p>OVA-E1 peptide, as SIINFEKL variant, triggers similar p38/JNK activation in mutant and normal thymocytes.</p>Fórmula:C47H76N10O14Forma y color:SolidPeso molecular:1005.181PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Fórmula:C54H69N11O6SPureza:98%Forma y color:SolidPeso molecular:1000.26KRAS G12D inhibitor 15
CAS:<p>Potent KRAS G12D inhibitor 15 targets cancer, potential for disease research. (WO2022042630A1, compound 243)</p>Fórmula:C53H71F2N7O5Forma y color:SolidPeso molecular:924.17RTIL 13
CAS:<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Fórmula:C30H55BrN2O3Forma y color:SolidPeso molecular:571.685R18
CAS:<p>14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.</p>Fórmula:C101H157N27O29S3Pureza:98%Forma y color:SolidPeso molecular:2309.69PROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Fórmula:C46H55F2N9O9SForma y color:SolidPeso molecular:948.05Pan-RAS-IN-7
CAS:<p>Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.</p>Fórmula:C59H76N8O8Forma y color:SolidPeso molecular:1025.28MRTF-A-IN-2
<p>MRTF-A-IN-2 (compound 16) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Forma y color:Odour SolidKRAS inhibitor-42
<p>KRAS inhibitor-42 (compound 8) is an effective USP7 inhibitor that exhibits high affinity for GDP-bound KRASG12D, with a Ki value of 2.7 μM.</p>Fórmula:C34H47ClN8O4S2Forma y color:SolidPeso molecular:730.28502TAK1-IN-2
<p>TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM[1].</p>Forma y color:SolidNUCC-0200808
<p>NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.</p>Forma y color:Odour SolidZINC05007751
CAS:<p>ZINC05007751 inhibits NEK6 (IC50=3.4μM), selective for NEK1/6, inactive on NEK2/7/9.</p>Fórmula:C18H12N2O3Pureza:99.7%Forma y color:SolidPeso molecular:304.3KRpep-2d
CAS:KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Fórmula:C109H183N43O25S2Forma y color:SolidPeso molecular:2560.02S6 Kinase Substrate Peptide 32
<p>S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.</p>Fórmula:C149H270N56O49Pureza:98%Forma y color:SolidPeso molecular:3630.1PROTAC K-Ras Degrader-4
CAS:<p>PROTAC K-Ras Degrader-4 is a molecule designed to selectively degrade oncogenic K-Ras mutants, a novel strategy for cancer research.</p>Fórmula:C50H60N12O6S2Forma y color:SoildPeso molecular:989.22KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Fórmula:C33H39ClF2N6O3Forma y color:SolidPeso molecular:641.15Rineterkib hydrochloride
CAS:<p>Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.</p>Fórmula:C26H28BrClF3N5O2Forma y color:SolidPeso molecular:614.89HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Fórmula:C26H27N7O2Forma y color:SolidPeso molecular:469.54YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Pureza:98%Forma y color:Odour SolidMRTX1133 formic
<p>MRTX1133: Selective inhibitor of KRAS G12D, effective in all protein states, targeting mutant cells.</p>Fórmula:C34H33F3N6O4Forma y color:SoildPeso molecular:646.67RP03707
CAS:<p>RP03707 is a PROTAC degrader of KRASG12D.</p>Fórmula:C55H58F3N11O4Forma y color:SolidPeso molecular:994.12KRAS mutant protein inhibitor 1
CAS:<p>KRAS mutant protein inhibitor 1 is a KRAS mutant protein inhibitor for potential treatment in cancer.</p>Fórmula:C31H27Cl3FN7O2Forma y color:SolidPeso molecular:654.95Anti-inflammatory agent 31
<p>Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.</p>Fórmula:C19H30O3Forma y color:SolidPeso molecular:306.44PROTAC SOS1 degrader-7
CAS:PROTACSOS1 degrader-7 (Example 15) is a SOS1 PROTAC degrader with specific antitumor activity.Fórmula:C51H64F2N10O4Forma y color:SolidPeso molecular:919.12BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Fórmula:C47H62N8O4SForma y color:SolidPeso molecular:835.11MRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Fórmula:C22H21N3Forma y color:SolidPeso molecular:327.42NK7-902
<p>NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.</p>Forma y color:Odour SolidSIAIS562055
<p>SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.</p>Fórmula:C49H62F3N7O5SForma y color:SolidPeso molecular:918.12HPK1-IN-20
CAS:<p>HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).</p>Fórmula:C26H28N6O2Forma y color:SolidPeso molecular:456.55U0124
CAS:<p>Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control</p>Fórmula:C8H10N4S2Pureza:98%Forma y color:SolidPeso molecular:226.32KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Fórmula:C32H37ClN8O2Forma y color:SolidPeso molecular:601.15PROTAC BRAF-V600E degrader-2
CAS:<p>PROTAC BRAF-V600E degrader-2 is a useful organic compound for research related to life sciences. The catalog number is T8744 and the CAS number is 2417296-82-1.</p>Fórmula:C42H39F2N7O8SForma y color:SolidPeso molecular:839.87ZZ151
<p>ZZ151 is an effective and selective SOS1 PROTAC with in vivo anti-tumor efficacy against KRAS-mutant cancers. This compound induces rapid and specific degradation of SOS1 and exhibits strong anti-proliferative activity against a wide range of KRAS mutation-driven cancer cells. In murine xenograft models with KRASG12D and G12V mutations, ZZ151 demonstrates superior anticancer activity. It represents a promising lead compound for developing new chemotherapeutic agents targeting KRAS mutations.</p>Fórmula:C54H68F3N9O6SForma y color:SolidPeso molecular:1028.23SW083688
CAS:<p>SW083688 is a potent and highly selective inhibitor of Thousand-And-One Kinase 2 (TAOK2) with an IC 50 value of 1.3 µmol/L.</p>Fórmula:C23H25N3O5SForma y color:SolidPeso molecular:455.53Cobimetinib (R-enantiomer)
CAS:<p>Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.</p>Fórmula:C21H21F3IN3O2Pureza:98%Forma y color:SolidPeso molecular:531.318PROTAC SOS1 degrader-4
<p>PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].</p>Fórmula:C53H65ClN8O7SPureza:98%Forma y color:SolidPeso molecular:993.65R 115777
CAS:<p>R 115777 is an inhibitor of farnesyl transferase.</p>Fórmula:C27H22Cl2N4OPureza:98%Forma y color:SolidPeso molecular:489.40JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Fórmula:C27H31N5O4SPureza:98%Forma y color:SolidPeso molecular:521.63p38 MAP Kinase Inhibitor Ⅵ
CAS:<p>p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.</p>Fórmula:C16H13FN2OS2Pureza:98.53%Forma y color:SolidPeso molecular:332.42Enniatin B1
CAS:<p>Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier and modulates ERK, NF-κB, and ACAT with an IC50 of 73 μM.</p>Fórmula:C34H59N3O9Pureza:98%Forma y color:SolidPeso molecular:653.858
