MAPK
Las MAPK son una familia de quinasas de proteínas involucradas en una variedad de procesos celulares, incluyendo crecimiento, proliferación, diferenciación y respuestas al estrés. La vía de señalización MAPK consta de varios niveles, incluidos ERK, JNK y p38 MAPK, cada uno con roles distintos en la función celular. La desregulación de la señalización MAPK está vinculada al cáncer, las enfermedades inflamatorias y los trastornos metabólicos. En CymitQuimica, ofrecemos una amplia gama de inhibidores y activadores de MAPK para apoyar su investigación en biología celular, transducción de señales y mecanismos de enfermedades.
Se han encontrado 886 productos de "MAPK"
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SM-7368
CAS:<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Fórmula:C10H5ClN4O5SPureza:99.64%Forma y color:SolidPeso molecular:328.69sodium lauroyl-α-hydroxyethyl sulfonate
CAS:<p>Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.</p>Fórmula:C14H27NaO5SPureza:≥98% - ≥98%Forma y color:SolidPeso molecular:330.41DB07268
CAS:<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Forma y color:SolidPeso molecular:321.33p-Cresyl sulfate potassium
CAS:<p>p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanine</p>Fórmula:C7H7KO4SPureza:99.38%Forma y color:SolidPeso molecular:226.29XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Fórmula:C36H46N8O3Pureza:98.75% - 99.7%Forma y color:SolidPeso molecular:638.8Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Fórmula:C24H27ClN2O3Pureza:99.23%Forma y color:SolidPeso molecular:426.94Rasarfin
CAS:<p>Rasarfin inhibits Ras and ARF6.</p>Fórmula:C23H24ClN3O3Pureza:97.98%Forma y color:SolidPeso molecular:425.91BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Fórmula:C22H26N6O2Pureza:98.11%Forma y color:SolidPeso molecular:406.48B-Raf IN 1
CAS:<p>B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.</p>Fórmula:C29H24F3N5OPureza:97.22% - 99.27%Forma y color:SolidPeso molecular:515.53K-Ras(G12C) inhibitor 9
CAS:<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Fórmula:C16H21ClIN3O4SPureza:97.33% - 97.45%Forma y color:SolidPeso molecular:513.78SB-590885
CAS:<p>SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).</p>Fórmula:C27H27N5O2Pureza:95.42% - 99.06%Forma y color:SolidPeso molecular:453.54ZT-12-037-01
CAS:<p>Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).</p>Fórmula:C21H31N5O2Pureza:99.56%Forma y color:SolidPeso molecular:385.5JNK-IN-7
CAS:<p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>Fórmula:C28H27N7O2Pureza:98.02% - 99.53%Forma y color:SolidPeso molecular:493.56PF-06260933
CAS:<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Fórmula:C16H13ClN4Pureza:99.63% - 99.97%Forma y color:SolidPeso molecular:296.75CK1-IN-1
CAS:<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Fórmula:C24H15F2N3Pureza:98.79%Forma y color:SolidPeso molecular:383.39CAY10404
CAS:<p>CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.</p>Fórmula:C17H12F3NO3SPureza:99.02%Forma y color:SolidPeso molecular:367.34BMS-582949 hydrochloride
CAS:<p>The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).</p>Fórmula:C22H27ClN6O2Pureza:97.57% - 98.75%Forma y color:SolidPeso molecular:442.95I-49 free base
<p>I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel</p>Fórmula:C23H26ClF3N4O2Pureza:99.64% - 99.88%Forma y color:SolidPeso molecular:482.92JNK Inhibitor VIII
CAS:<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Fórmula:C18H20N4O4Pureza:98.93%Forma y color:SolidPeso molecular:356.38Refametinib
CAS:<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Fórmula:C19H20F3IN2O5SPureza:99.53% - >99.99%Forma y color:SolidPeso molecular:572.34ARS-1620
CAS:<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Fórmula:C21H17ClF2N4O2Pureza:98.86%Forma y color:SolidPeso molecular:430.84Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Fórmula:C19H9Cl2F2N3OSPureza:97.88% - 99.75%Forma y color:SolidPeso molecular:436.26Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Fórmula:C25H17ClF4N6O3SForma y color:SolidPeso molecular:592.95K-Ras-IN-1
CAS:<p>K-Ras-IN-1 is a K-Ras inhibitor.</p>Fórmula:C11H13NOSPureza:98.72%Forma y color:SolidPeso molecular:207.29Acumapimod
CAS:<p>Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).</p>Fórmula:C22H19N5O2Pureza:≥95%Forma y color:SolidPeso molecular:385.42JNK-IN-8
CAS:<p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Forma y color:SolidPeso molecular:507.59SUN11602
CAS:<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Fórmula:C26H37N5O2Pureza:99.36%Forma y color:SolidPeso molecular:451.6KRPEP-2D acetate
<p>KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.</p>Fórmula:C110H186N44O27S2Pureza:98.94%Forma y color:SolidPeso molecular:2621.06Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Forma y color:SolidPeso molecular:433.33N-tert-butyl-α-Phenylnitrone
CAS:<p>N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.</p>Fórmula:C11H15NOPureza:99.46% - 99.84%Forma y color:SolidPeso molecular:177.24ERK5-IN-1
CAS:<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Fórmula:C25H29N7O2Pureza:97.70%Forma y color:SolidPeso molecular:459.54N-Feruloyloctopamine
CAS:<p>N-Feruloyloctopamine is a natural product.</p>Fórmula:C18H19NO5Pureza:99.70%Forma y color:SolidPeso molecular:329.356H05 (TFA)
CAS:<p>6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.</p>Fórmula:C22H31ClF3N3O4S3Pureza:98.83%Forma y color:SolidPeso molecular:590.14ML-098
CAS:<p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>Fórmula:C19H19NO3Pureza:99.06% - 99.23%Forma y color:SolidPeso molecular:309.36MK2-IN-3
CAS:<p>MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.</p>Fórmula:C21H16N4OPureza:99.01%Forma y color:SolidPeso molecular:340.381-(4-methansulfinylphenyl)ethanone
CAS:<p>The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.</p>Fórmula:C9H10O2SPureza:99.48%Forma y color:SolidPeso molecular:182.24CCT196969
CAS:<p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>Fórmula:C27H24FN7O3Pureza:98.93% - 99.65%Forma y color:SolidPeso molecular:513.52Cefotetan
CAS:<p>Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.</p>Fórmula:C17H17N7O8S4Pureza:95.72% - 99.38%Forma y color:SolidPeso molecular:575.62SD 0006
CAS:<p>SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.</p>Fórmula:C20H20ClN5O2Pureza:98.32%Forma y color:SolidPeso molecular:397.86CMPD1
CAS:<p>CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).</p>Fórmula:C22H20FNO2Pureza:99.8%Forma y color:SolidPeso molecular:349.4Talmapimod
CAS:<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Fórmula:C27H30ClFN4O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:513AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Forma y color:SolidPeso molecular:485.581588-A4
CAS:<p>1588-A4 (ARS-1620 Intermediate) is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.</p>Fórmula:C17H19BrClFN4O2Pureza:98.59%Forma y color:SolidPeso molecular:445.71GSK-114
CAS:<p>GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.</p>Fórmula:C19H23N5O4SPureza:99.51%Forma y color:SolidPeso molecular:417.48Varenicline Tartrate
CAS:<p>Varenicline Tartrate (CP 526555-18) is a benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist.</p>Fórmula:C13H13N3·C4H6O6Pureza:98.23% - 98.32%Forma y color:Tan SolidPeso molecular:361.35Encorafenib
CAS:<p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>Fórmula:C22H27ClFN7O4SPureza:99.51% - 99.83%Forma y color:SolidPeso molecular:540.01AG126
CAS:<p>AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.</p>Fórmula:C10H5N3O3Pureza:97.35%Forma y color:SolidPeso molecular:215.16D-JNKI-1 acetate
<p>D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.</p>Fórmula:C166H290N66O42Pureza:99.48%Forma y color:SolidPeso molecular:3882.5TAK-733
CAS:<p>TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Fórmula:C17H15F2IN4O4Pureza:98.31% - 99.53%Forma y color:SolidPeso molecular:504.23Bentamapimod
CAS:<p>Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.</p>Fórmula:C25H23N5O2SPureza:97.04% - 99.92%Forma y color:SolidPeso molecular:457.55
